Metabolic Syndrome: Past, Present and Future

Lemieux, Isabelle; Després, Jean‐Pierre

doi:10.3390/nu12113501

Cited by 143 publications

(105 citation statements)

References 61 publications

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“…In particular, using the NMR buckets as input variables, the PCA was preliminarily used to explore the potential differences in the metabolome profile at baseline and/or presence of outliers (95% confidence ellipse using Hotelling’s T 2 statistics). OPLS-DA analysis was also performed on NMR bucket-reduced data, in which results were clearly discriminated in the first predictive t [ 1 ] component. The parameters calculated to assess the validity of the established models were the total amount of variation between and within the groups (R 2 Y and R 2 X) and the predictive ability of the models as determined by permutation test and seven-fold cross-validation (Q 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…For the Nuclear Magnetic Resonance (NMR) Spectroscopy analysis, 540 µL of urine, thawed at room temperature and mixed, was added to 60 µL of saline buffer solution (KH 2 PO 4 , in 100% D 2 O containing 0.03% w/w TSP as chemical shift reference and 2 mM sodium azide, pH 7.4), and transferred into a 5mm NMR tube. 1 H-NMR spectra were acquired using a Bruker Avance III 600 Ascend NMR spectrometer (Bruker, Milan, Italy), operating at 600.13 MHz for 1H observation, equipped with a TCI cryoprobe (Triple Resonance inverse Cryoprobe) incorporating a z-axis gradient coil and automatic tuningmatching (ATM). Samples were loaded on a Bruker Automatic Sample Changer, interfaced with the IconNMR software (Bruker, Milan, Italy), and analyzed in automatic mode, setting a time delay of 5 min between sample injection and pre-acquisition calibrations for complete temperature equilibration (300 K).…”

Section: Urine Metabolomics By Nuclear Magnetic Resonance Spectroscopymentioning

confidence: 99%

“…BMI: body mass index; WHR: waist-to-hip ratio; HDL: high-density lipoprotein; LDL: low-density lipoprotein; BP: blood pressure; MS: metabolic syndrome. 1 With the exception of smoking habit and MS, missing values were present only for one patient. 2 No subjects in our study sample reached the maximum IMI score of 11.…”

Section: Dietary Habitsmentioning

confidence: 99%

“…Metabolic syndrome (MS) is characterized by several metabolic abnormalities, including abdominal obesity, elevated values of triglycerides, blood pressure, or fasting glucose, or reduced high-density lipoprotein (HDL) cholesterol [ 1 ]. This pathological condition has been increasing over recent years, mainly due to changes in lifestyle and unbalanced diets, with a prevalence of 10–40% in the European population, depending on age and gender [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Factor loading matrix1 and explained variances for the three major dietary patterns identified by principal component factor analysis on baseline nutrient information. Italy, 2018-2019.…”

mentioning

confidence: 99%

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Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome

et al. 2021

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Diet is a major driver of gut microbiota variation and plays a role in metabolic disorders, including metabolic syndrome (MS). Mycorrhized foods from symbiotic agriculture (SA) exhibit improved nutritional properties, but potential benefits have never been investigated in humans. We conducted a pilot interventional study on 60 adults with ≥ 1 risk factors for MS, of whom 33 consumed SA-derived fresh foods and 27 received probiotics over 30 days, with a 15-day follow-up. Stool, urine and blood were collected over time to explore changes in gut microbiota, metabolome, and biochemical, inflammatory and immunologic parameters; previous dietary habits were investigated through a validated food-frequency questionnaire. The baseline microbiota showed alterations typical of metabolic disorders, mainly an increase in Coriobacteriaceae and a decrease in health-associated taxa, which were partly reversed after the SA-based diet. Improvements were observed in metabolome, MS presence (two out of six subjects no longer had MS) or components. Changes were more pronounced with less healthy baseline diets. Probiotics had a marginal, not entirely favorable, effect, although one out of three subjects no longer suffered from MS. These findings suggest that improved dietary patterns can modulate the host microbiota and metabolome, counteracting the risk of developing MS.

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Section: Methodsmentioning

confidence: 99%

Section: Urine Metabolomics By Nuclear Magnetic Resonance Spectroscopymentioning

confidence: 99%

Section: Dietary Habitsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Factor loading matrix1 and explained variances for the three major dietary patterns identified by principal component factor analysis on baseline nutrient information. Italy, 2018-2019.…”

mentioning

confidence: 99%

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Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome

et al. 2021

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The association of metabolic syndrome score trajectory patterns with risk of all cancer types

Deng,

Liu,

Liu

et al. 2024

Cancer

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BackgroundMetabolic syndrome (MetS) elevates cancer risk. However, a single MetS assessment does not fully reveal the long‐term association with cancer. Inflammation, alongside MetS, could synergistically expedite both the onset and advancement of cancer. This study aims to investigate MetS score trajectories and cancer risk in a large, prospective cohort study.MethodsThe authors prospectively examined the relationship between MetS score trajectory patterns and new‐onset cancer in 44,115 participants. Latent mixture modeling was used to identify the MetS score trajectories. Cox proportional hazards regression models were used to evaluate the association between MetS score trajectory patterns and the risk of overall and site‐specific cancers.ResultsFour MetS score trajectory patterns were identified: low‐stable (n = 4657), moderate‐low (n = 18,018), moderate‐high (n = 18,288), and elevated‐increasing (n = 3152). Compared to participants with a low‐stable trajectory pattern, the elevated‐increasing trajectory pattern was associated with an elevated risk of overall (hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.04–1.55), breast (HR, 2.11; 95% CI, 1.04–4.34), endometrial (HR, 3.33; 95% CI, 1.16–6.77), kidney (HR, 4.52; 95% CI, 1.17–10.48), colorectal (HR, 2.54; 95% CI, 1.27–5.09), and liver (HR, 1.61; 95% CI, 1.09–4.57) cancers. Among participants with chronic inflammation (C‐reactive protein levels ≥3 mg/L), the elevated‐increasing trajectory pattern was significantly associated with subsequent breast, endometrial, colorectal, and liver cancers.ConclusionsTrajectories of MetS scores are associated with the occurrence of cancers, especially breast, endometrial, kidney, colorectal, and liver cancers, emphasizing the importance of long‐term monitoring and evaluation of MetS.Plain Language Summary The association between long‐term elevated metabolic syndrome (MetS) scores and a heightened risk of various cancers is a pivotal finding of our study. Our research further indicates that individuals with MetS, particularly when coupled with chronic inflammation, are at an increased risk of cancer. We propose that sustained monitoring and management of MetS could be beneficial in reducing cancer risk.

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Spicy Food and Chili Peppers and Multiple Health Outcomes: Umbrella Review

Huang

Liu

2022

Molecular Nutrition Food Res

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Spicy foods and chili peppers contain the primary ingredient capsaicin, which has potential health benefits. However, their efficacy in some health outcomes is also fiercely disputed, and some side effects have been confirmed. To assess the quality and strength of the associations between spicy food and chili pepper consumption and different health outcomes. An umbrella review is performed in humans. Eleven systematic reviews and meta‐analyses with a total of 27 findings are identified. The health effect of consuming spicy food and chili peppers is unclear. Furthermore, the characteristics and context of different world regions and populations should be carefully considered. Direct correlations exist in esophageal cancer, gastric cancer, and gallbladder cancer. However, negative connections are reported in metabolism, mortality, and cardiovascular disease. Dose–response analysis reveals a significant nonlinear relationship between gastric cancer risk and capsaicin intake. The consumption of spicy foods and chili peppers is typically safe. However, high‐quality proof is available to confirm this conclusion.

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Metabolic Syndrome: Past, Present and Future

Abstract: Most clinicians and health professionals have heard or read about metabolic syndrome [...]

Cited by 143 publications

References 61 publications

Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome

Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome

The association of metabolic syndrome score trajectory patterns with risk of all cancer types

Spicy Food and Chili Peppers and Multiple Health Outcomes: Umbrella Review

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