Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients

Abstract

We hypothesised that the established association of endothelial lipase (EL) plasma levels with atherogenic lipid profile is altered in acute heart failure (AHF) and additionally affected by overlapping metabolic syndrome (MetS). We examined the association of EL plasma levels and lipid/lipoprotein plasma levels in AHF patients without and with overlapping MetS. The study was performed as a single-centre, observational study on 152 AHF patients, out of which 85 had overlapping MetS. In the no-MetS group, EL plasma levels were significantly positively correlated with plasma levels of atherogenic lipids/lipoproteins, including total cholesterol, low-density lipoprotein (LDL)-cholesterol, total LDL particles and triglycerides, but also with plasma levels of antiatherogenic high-density lipoprotein (HDL)-cholesterol, total HDL particles and small HDL particles. In the MetS group, EL plasma levels were positively correlated with triglyceride and small LDL-particle levels, and significantly negatively correlated with plasma levels of large HDL particles as well as with LDL- and HDL-particle size, respectively. EL- and lipid/lipoprotein- plasma levels were different in the no-MetS patients, compared to MetS patients. The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF.

Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein

“…hEL-serum and hEV-serum were generated as described above with exception that 100% human serum was incubated with EL-overexpressing or EV-control HepG2 cells for 8 h. EL-modified and EV-control samples were analysed using the AXINON ® lipoFIT ® –S100 test system (Numares Health, Regensburg, Germany) as described in our previous reports 35 , 36 .…”

Emerging Roles of Vascular Endothelium in Metabolic Homeostasis

“…However, genetic studies show that few SNPs of EL gene are related to changes in plasma HDL-C concentrations. Conflicting data have also been obtained from studies with human patients regarding the association of EL and HDL concentrations 132, 133, 166, 167 . In ECs, EL can be induced by inflammatory cytokines (i.e.…”

Parameters of Carbohydrate Metabolism and Expression of Liver Steatosis in Patients with Nonalcoholic Fatty Liver Disease and Hypertensive Depending on Lipid Parameters

“…Изучение зависимостей концентрации ЭЛ с показателями липидограммы выявило положительную связь только с уровнем общего холестерина и отрицательныйс уровнем ЛПНП, что также было представлено в исследовании Tani M. et al [18]. Отсутствие прямых ассоциаций между уровнями ЭЛ и содержанием в крови ЛПВП может быть связано с вероятным угнетением активности липопротеинлипазы у избранного для исследования контингента и перекрестного участия ЭЛ в метаболизме ЛПНП, а так же с разным метаболическим классом исследуемых, что так же отмечено в исследовании Potočnjak I. et al [15].…”

“…Сейчас обнародованы данные о том, что нет различий в концентрации ЭЛ в группах с низкими и высокими ЛПВП у здоровых взрослых лиц [10]. Однако при наличии метаболических нарушений возникает положительная корреляция ЭЛ с триглицеридами и мелкими ЛПНП и отрицательная с крупными ЛПВП [15], что может объяснять повышенные уровни ЭЛ у лиц с коронарной кальцификацией [21].…”