Metabolic syndrome, metabolic components, and their relation to the risk of pancreatic cancer

Park, Sung Keun; Oh, Chang‐Mo; Kim, Min Ho; Ha, Eun–Hee; Choi, Yong-Sung; Ryoo, Jae‐Hong

doi:10.1002/cncr.32737

Cited by 34 publications

(39 citation statements)

References 30 publications

(31 reference statements)

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“…However, we found no association of obesity with survival in PC, contrary to other studies that showed that obesity is associated with poorer survival [43,44,48]. Previous reports proved a 31-47% increased risk of PC patients with metabolic syndrome [21,49,50], but this was not confirmed in our study. The prevalence of the metabolic syndrome in population with cardiovascular diseases in Romania is up to 40% [51], but recent data in general population are lacking.…”

Section: Discussioncontrasting

confidence: 99%

Risk Factors in Pancreatic Adenocarcinoma: the Interrelation with Familial History and Predictive Role on Survival

Petrusel

Bilibou²,

Drug

et al. 2020

JGLD

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Background and Aims: Pancreatic cancer is associated with poor survival and quality of life. In Romania the prognostic influence of known risk factors for pancreatic adenocarcinoma, such as age, smoking, chronic pancreatitis, diabetes mellitus, and obesity is little known. Their importance in developing cancer in families with a history of adenocarcinoma is less studied. This study aims to assess the risk factors in pancreatic ductal adenocarcinoma, in familial pancreatic adenocarcinoma, in neuroendocrine tumors and to evaluate their predictive role on survival. Methods: We performed a prospective bicentric study of patients with pancreatic tumors detected in transabdominal imaging; we assessed the risk factors and their possible association with survival. Results: 312 pancreatic cancer patients (279 with pancreatic ductal adenocarcinoma and 24 patients with neuroendocrine tumors, and nine patients with other malignant types) and 312 controls were included. The median body mass index was significantly higher in patients with neuroendocrine tumors. Positive family history for pancreatic cancer was found in 4% of patients with pancreatic cancer. The risk for familial pancreatic carcinoma was associated with the presence of new-onset diabetes (OR: 4.64, p=0.018). The multivariate logistic analysis suggested that advanced age (OR: 1.67), smoking (OR: 1.67), low body mass index (OR: 12.07), and diabetes (OR: 3.91) were risk factors for pancreatic cancer. The overall survival analysis after adjustment for age and tumor stage showed only advanced tumoral stage (HR=1.6, p=0.003) and metastasis as independent predicting factors (HR=1.67, p<0.001). Conclusion: Our study suggests that diabetes, smoking, underweight, and age over 60 years are risk factors for pancreatic cancer. Patients with a family history of pancreatic cancer, especially those with new-onset diabetes, should be followed carefully and considered for screening. Only an advanced tumor stage was associated with poor overall survival for patients with pancreatic ductal adenocarcinoma.

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Section: Discussioncontrasting

confidence: 99%

Risk Factors in Pancreatic Adenocarcinoma: the Interrelation with Familial History and Predictive Role on Survival

Petrusel

Bilibou²,

Drug

et al. 2020

JGLD

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“… 88 The last important piece of the puzzle of environmental factors that may potentially cause exposition to the more frequent occurrence of MetS is air pollution, as demonstrated in the research by, for example, Zhang et al, 89 Yang et al 90 or Matthiessen et al 91 MetS is associated with the development of many other diseases. Available epidemiological and laboratory data indicate that MetS is a potential risk factor for developing certain types of cancers 92 such as colorectal, liver, pancreatic and postmenopausal breast cancer. 93 It has been postulated that the link between MetS and cancer is due to obesity, high blood glucose and other components of MetS.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between the Metabolic Syndrome and the Place of Residence in the Local Community on the Example of the Janów Lubelski District in Eastern Poland: A Population-Based Study

Nowicki¹,

Ślusarska²,

Naylor³

et al. 2021

DMSO

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“…[1][2][3] The National Cholesterol Education Program's Adult Treatment Panel ш (NCEP: ATP ш), World Health Organization (WHO) and International Diabetes Federation (IDF) employ this syndrome to highlight the risk of individuals developing cardiovascular disease (CVD) and type 2 diabetes (T2DM). 1,4 Moreover, MetS increases mortality due to CVD, 1,5,6 and is associated with the risk of certain types of cancers, 7 such as colorectal cancer, 8 pancreatic cancer, 9 and breast cancer. 10 Although different countries or organizations have recommended different criteria for the definition of MetS, abdominal obesity and insulin resistance are believed to be at the core of most cases of MetS.…”

Section: Introductionmentioning

confidence: 99%

<p>Screening for Metabolic Syndrome Using an Integrated Continuous Index Consisting of Waist Circumference and Triglyceride: A Preliminary Cross-sectional Study</p>

Liu

Zhu

2020

DMSO

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Background: It has been suggested that hypertriglyceridemic waist (HW) phenotype is strongly associated with metabolic syndrome (MetS); however, there are very limited studies integrating triglyceride (TG) and waist circumference (WC) into a continuous variable to investigate the predictive power of this phenotype. Inspired from the triglyceride glucose index (TyG), we developed an integrated continuous index termed waist-triglyceride index (WTI) which was calculated as Ln [TG (mg/dl) WC (cm)/2]. Objective: We aimed to examine the potential of WTI in screening for MetS by comparing this quantitative index with the qualitative HW phenotype and other frequently used indices. Methods: A cross-sectional study was conducted in a total of 3460 non-diabetic adults who participated in an annual health checkup. MetS was defined by the update National Cholesterol Education Program/Adult Treatment Panel ш criteria for Asian Americans. Receiving operating characteristic (ROC) curve and areas under the curve (AUC) were employed to evaluate the performance of the involved indices in screening for MetS. Statistical differences among the AUC values of the indices were compared. Results: In both genders, the AUC value of WTI, TyG or HW phenotype was markedly larger than that of each anthropometric index alone. In men, there were no statistical differences in the AUC values among WTI, TyG and HW phenotype, whereas in women, the AUC value of WTI was significantly larger than that of HW phenotype [difference between area (DBA): 0.042, 95% CI: 0.0224-0.0617, P < 0.0001] and was nominally and significantly smaller than that of TyG (DBA: 0.00646, 95% CI: 0.000903-0.012, P = 0.0227). Conclusion: Our results suggest that there are discriminatory performance between the WTI and HW phenotype in the detection of MetS in women rather than in men. Appropriate markers for screening MetS in population study should be considered according to the genders.

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Metabolic syndrome, metabolic components, and their relation to the risk of pancreatic cancer

Cited by 34 publications

References 30 publications

Risk Factors in Pancreatic Adenocarcinoma: the Interrelation with Familial History and Predictive Role on Survival

Risk Factors in Pancreatic Adenocarcinoma: the Interrelation with Familial History and Predictive Role on Survival

The Relationship Between the Metabolic Syndrome and the Place of Residence in the Local Community on the Example of the Janów Lubelski District in Eastern Poland: A Population-Based Study

<p>Screening for Metabolic Syndrome Using an Integrated Continuous Index Consisting of Waist Circumference and Triglyceride: A Preliminary Cross-sectional Study</p>

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