Metabolic syndrome, malnutrition, and its associations with cardiovascular and all-cause mortality in hemodialysis patients: Follow-up for three years

Ati, Z. El; Machfar, Hanene; Boussafa, Hamza; Ati, N.; Sioud, Olfa; Zantour, B.; Bouzidi, H.; Elati, Mohamed

doi:10.4103/1319-2442.279932

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…In studies, the prevalence of metabolic syndrome in hemodialysis patients varies according to the diagnostic criteria for metabolic syndrome and the number of patients [9][10][11][19][20][21][22][23]. It appears, that the prevalence of metabolic syndrome among patients on hemodialysis was nearly half in different studies [9,10,21,22] and metabolic syndrome identified in this study (48.4%), were similar.…”

Section: Discussionsupporting

confidence: 55%

“…Also supporting studies made in [9,10,21,24,26], dry weight, BMI, waist circumference, serum triglycerides were significantly higher and HDL-C levels were lower in patients with metabolic syndrome than other groups. As in this study, BMI is also high in patients with metabolic syndrome (p < 0.05), is an independent predictor of metabolic syndrome in hemodialysis patients without diabetes and dyslipidemia [9,15,22,24,27]. These discrepancies in the results of different studies could be attributed to the different populations and healthcare settings between these studies and the current study.…”

Section: Discussioncontrasting

confidence: 47%

“…There were 115 hemodialysis patients evaluated by NCEP-ATP III and the International Diabetes Federation (IDF) criteria; metabolic syndrome was identified according to NCEP-ATP III 41.7 % and IDF 42.6% [21]. Metabolic syndrome was 50.0% in 100 hemodialysis patients according to NCEP-ATP III criteria [22]. Vogt and others identified metabolic syndrome in 98 (74.5%) patients according to IDF criteria [23].…”

Section: Discussionmentioning

confidence: 99%

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Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

2021

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Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.

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Section: Discussionsupporting

confidence: 55%

Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

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Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

2021

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“…This value is higher in comparison to other studies. [21][22][23][24][25][26][27][28] The SGA tool is well recognized and well researched. It is the only tool recommended by the AS-PEN board of directors, and a patient generated SGA is used widely in clinics.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Malnutrition in Patients having Chronic Kidney Disease at A Tertiary Care Center in Karachi Pakistan

Ahmed

Khurram

Daniyal

et al. 2020

APMC

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Background: Chronic kidney disease and associated malnutrition is major health problem in developing countries like Pakistan. CKD patient have been related with body wasting and malnutrition. In this study we assess the prevalence of Malnutrition in chronic kidney disease patients. Objective: To determine the prevalence of malnutrition in patients with chronic kidney disease. Study Design: The type of study is a cross-sectional study. Settings: Dialysis and kidney care center in Karachi-Pakistan. Duration: 6 months from December 2017 to May 2018. Methodology: Patients with chronic kidney disease (CKD) were included and patients with severe comorbid conditions were excluded from the study. Diagnosis of CKD was made via detailed history and clinical examination and relevant laboratory investigations. Patients were classified into 3 SGA grades. Data was collected in a pre-designed proforma. Results: 150 patients were included in the study. The mean age of patients was 58.4 ± 5.86 years. There were n= 93 (62%) males and n= 57 (38%) females. The frequency of malnutrition was n= 63 (42%) were moderately malnourished and n= 32 (21.33%) were severely malnourished. None of the patients under the age of 50 years showed signs of malnutrition. The most common etiology for CKD was diabetes mellitus in n= 75 (50%). The mean BMI of 27.6 ± 5.1 kg/m2, Triceps skin fold thickness was 18.2 ± 7.1 mm and a mean mid upper arm circumference of 23.2 ± 3.9 mm2 respectively. Chi-square test shows a significant association between the incidence of malnutrition and undialysed patients suffering from chronic kidney disease. Having a p-value of <0.001. Conclusion: The frequency of malnutrition in undialyzed patients with CKD was very high, mild to moderate malnutrition was more prevalent than severe malnutrition.

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“…High rates of nutritional deficiency are widely reported in patients undergoing maintenance hemodialysis [ 1 , 2 ]. Malnutrition can cause micro-inflammatory reactions, leading to malnutrition-inflammation-atherosclerosis syndrome (MIA) and cardiovascular events, seriously affecting the lifespan and the general wellbeing of patients [ 3 , 4 ]. An optimal diet is critical to improve the outcomes of hemodialysis patients [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Substrate-Inspired Fluorescence-Based Albumin Detection Improves Assessment of Clinical Outcomes in Hemodialysis Patients Receiving a Nursing Nutrition Intervention

You

Wang

2021

Med Sci Monit

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Background Albumin level does not precisely reflect nutritional status. We aimed to investigate the impact of a nutrition intervention on hemodialysis patients by use of fluorescence-based plasma albumin (FPA) detection. Material/Methods Eighty patients underwent maintenance hemodialysis for more than half a year and had a mean albumin <3.5 g/dL for over 3 months. The subjects were randomly divided into either a Control Group (CG) or an Intervention Group (IG). The IG received nutritional supplementation, and the CG group received routine nutritional support for 12 months. FPA and plasma albumin (PA) concentrations were measured. The fluorescence probe 1,3-Dichloro-7-hydroxy-9,9-dimethyl-2(9H)-acridone methyl biphenyl benzoate was used in FPA detection. Quality of life was estimated using WHOQOL-BREF (Quality of Life Scale developed through the World Health Organization), the 36-Item Short-Form Survey (SF-36), and the 6-minute walking test (6MWT). Results After a 6-month and a 12-month intervention, PA and FPA concentrations increased, and the increase in FPA concentration was higher than that of PA in the IG group ( P <0.05). Comparatively, the parameters of quality of life and 6MWT were improved in the IG group ( P <0.05) but there were only minor changes in the CG group ( P >0.05). There is an obvious association between the changes in FPA concentration and the parameters of quality of life and 6MWT but not PA. Conclusions Use of the fluorescence probe improves the detection sensitivity of plasma albumin and provides a potential method to assess clinical outcomes in hemodialysis patients.

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Metabolic syndrome, malnutrition, and its associations with cardiovascular and all-cause mortality in hemodialysis patients: Follow-up for three years

Cited by 8 publications

References 18 publications

Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients

The Prevalence of Malnutrition in Patients having Chronic Kidney Disease at A Tertiary Care Center in Karachi Pakistan

A Novel Substrate-Inspired Fluorescence-Based Albumin Detection Improves Assessment of Clinical Outcomes in Hemodialysis Patients Receiving a Nursing Nutrition Intervention

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