Metabolic Syndrome, Inflammation, and Incident Heart Failure in the Elderly

Suzuki, Takeki; Katz, Ronit; Jenny, Nancy S.; Zakai, Neil A.; LeWinter, Martin M.; Barzilay, Joshua I.; Cushman, Mary

doi:10.1161/circheartfailure.108.785485

Cited by 72 publications

(48 citation statements)

References 50 publications

(39 reference statements)

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“…Today, it is considered that this inflammatory process of arterial wall is a consequence of different stimuli. Increased levels of adhesion molecules ICAM-1 and VCAM-1, and hsCRP in patients with IHD are reported by many authors [7]. Accordingly the similar results are obtained in our study.…”

Section: Discussionsupporting

confidence: 93%

Influence of Oxidative Stress and Inflammation on the Development of Ischemic Heart Disease in Patients With Type 2 Diabetes Mellitus

Lilic¹,

Djindjic²,

Kostić³

et al. 2016

Russ J Cardiol

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Aim. Ischemic heart disease (IHd) is the result of endothelial dysfunction, which is associated with inflammation, increased oxidative stress and hyperglycemia. the aim of our study was to examine the aetiology, importance and intensity of inflammation and oxidative stress in IHd development in patients with diabetes mellitus (dM) type 2. Material and methods. We included 60 male patients with IHd of whom 30 with diabetes type 2. Control group comprised of 12 healthy participants. We analyzed the lipid status, quality of glycemic control (daily glycemia profile -MBG and HbA 1c ), lipid peroxidation (malondialdehyde-MdA) and inflammation: high sensitivity C reactive protein (hsCRP), intercellular and vascular adhesion molecule-1 (ICAM-1, VCAM-1). Results. Patients with dM type 2 and IHd were obese with higher levels of HbA 1c and MBG compared to other two groups. Systolic and diastolic blood pressure, triglycerides, total and LdL cholesterol were significantly higher and HdL was lower in all patients with IHd compared to the control group. CRP levels, ICAM-1, VCAM-1 and MdA were significantly higher in the groups with IHd compared to the control. MdA and VCAM-1 were higher in patients with IHd and type 2 dM than in patients with IHd. there was a significant positive correlation between hsCRP and LdL cholesterol in patients with IHd, regardless of the presence of dM. Significant positive correlation between VCAM-1 and HbA1c values, and between ICAM-1 and hsCRP were shown only in patients with IHd and dM type 2. Conclusion. Inflammation, increased oxidative stress, lipid and metabolic disorders showed significant correlation and have an important pathogenic role in the development of IHd, particularly in patients with dM type 2. Increased levels of hsCRP, VCAM-1 and products of lipid peroxidation are characteristic markers of endothelial inflammation and indicators of the presence of atherosclerotic plaque in patients with dM type 2. BMI -body mass index, CAM -cellular adhesive molecules, dM -diabetes mellitus, HbA1c -glycosylated haemoglobin, HdL -high density lipoprotein, hsCRP -high sensitivity C reactive protein, ICAM-1 -intercellular adhesion molecule-1, IHd -Ischemic heart disease, LdL -low density lipoprotein, MBG -daily glycemia profile, MdA -malondialdehyde, SAP -stable angina pectoris, tCtotal cholesterol, UKPdS study -the United Kingdom Prospective diabetes Study VCAM-1 -vascular adhesion molecule-1. Цель. Ишемическая болезнь сердца (ИБС) является следствием эндотели-альной дисфункции, которая связана с воспалением, повышением окисли-тельного стресса и гипергликемии. Целью нашего исследования явилось изучение этиологии, значения и интенсивности воспаления и оксидативного стресса в развитии ИБС у больных сахарным диабетом (СД) 2 типа. Материал и методы. Мы включили 60 пациентов мужского пола с ИБС, 30 из которых с СД 2 типа. Группу контроля составили 12 здоровых участников. Мы проанализировали липидный статус, качество гликемического контроля (ежедневный гликемический профиль -MBG и HbA 1c ), перекисног...

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Section: Discussionsupporting

confidence: 93%

Influence of Oxidative Stress and Inflammation on the Development of Ischemic Heart Disease in Patients With Type 2 Diabetes Mellitus

Lilic¹,

Djindjic²,

Kostić³

et al. 2016

Russ J Cardiol

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“…Probability value for trend over quartiles was Ͻ0.001 (log-rank test). Previous studies have reported associations between interleukin-6, tumor necrosis factor-␣, and C-reactive protein 8,10,13,26 and risk of HF. Ingelsson et al 9 reported relationships between erythrocyte sedimentation rate and incidence of HF.…”

Section: Discussionmentioning

confidence: 97%

Leukocyte Count and Incidence of Hospitalizations Due to Heart Failure

Engström

Melander

Hedblad

2009

Circ: Heart Failure

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Background-Leukocyte concentration in blood is a classical marker of systemic inflammation. Whether high leukocyte counts are associated with incidence of heart failure (HF) is unknown. This population-based study explored whether the leukocyte concentrations were associated with incidence of hospitalizations due to HF. Methods and results-Leukocyte counts were measured in 16 940 men from the general population (mean age 44 years) without history of myocardial infarction or stroke. Incidence of hospitalizations due to HF (primary diagnosis) was monitored over 23 years of follow-up, in relation to quartiles of leukocytes. Subjects with myocardial infarction during follow-up were censored in the main analysis. During the follow-up, 436 men were hospitalized due to HF. Incidence of HF hospitalizations was increased in men with high leukocyte counts. After adjustments for confounding factors, the adjusted hazards ratio (HR, 95% CI) for HF hospitalization was 1.00 (reference), 1.26 (0.93 to 1.7), 1.24 (0.91 to 1.7), and 1.73 (1.3 to 2.3), respectively, for men with leukocytes in the 1st, 2nd, 3rd, and 4th (highest) quartiles (trend, PϽ0.001). This relationship was consistent in smokers and nonsmokers and in men with and without hypertension, respectively. Conclusion-High leukocyte counts in middle-aged men were associated with increased long-term incidence of HF hospitalizations. (Circ Heart Fail. 2009;2:217-222.)

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“…184,185 Among individual components of MetS, high triglyceride level was the second most common (74%), after elevated blood pressure. 186 A high prevalence of triglyceride levels Ն150 mg/dL (72%) was also observed in patients with MetS and CVD.…”

Section: Prevalence Of Elevated Triglyceride In Metsmentioning

confidence: 99%