Metabolic syndrome in women with chronic pain

Loevinger, Barbara L.; Müller, Daniel; Alonso, Carmen; Coe, Christopher L.

doi:10.1016/j.metabol.2006.09.001

Cited by 95 publications

(111 citation statements)

References 43 publications

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“…The association between MetS and discomfort and symptoms, which was analyzed in our study, has not been reported earlier, yet there are some reports about the association of MetS and chronic pain: young adult and middle-aged women with fibromyalgia had an almost sixfold higher risk of MetS than demographically similar women without chronic pain [29]. It is worth noting, though, that the 15D dimension of discomfort and symptoms primarily measures the experience of pain, so in this light our finding is in line with earlier findings.…”

Section: Comparison With Existing Literaturecontrasting

confidence: 51%

Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study

et al. 2008

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Section: Comparison With Existing Literaturecontrasting

confidence: 51%

Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study

et al. 2008

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“…Moreover, factor analysis in children with MS showed indicators of low-grade inflammation and the same endocrine factors (Retnakaran et al 2006). In women with chronic pain, meeting three and more numbers of MSC, also higher ratios of urinary norepinephrine/ epinephrine and norepinephrine/cortisol were detected (Loevinger et al 2007).…”

Section: Discussionmentioning

confidence: 95%

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Žák

Tvrzická

Vecka

et al. 2007

Tohoku J. Exp. Med.

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Metabolic syndrome (MS) is defined by the clustering of several components (MSC), which include abdominal fat accumulation, impaired glucose homeostasis, hypertriglyceridemia, lowered high-density lipoprotein cholesterol, increased blood pressure, and hyperuricemia. Metabolic syndrome is also accompanied by increased oxidative stress and inflammation as well as by altered composition of esterified fatty acids (FA). Therefore, we have investigated 210 men (categorized into six groups with increasing number of MSC) to find trends in the extent of oxidative stress, FA pattern and frequency of pathological alleles of the selected candidate genes for lipid metabolism. Increasing number of MSC was connected with the raised serum glucose and insulin, increased concentrations of conjugated dienes in low-density lipoprotein (all p < 0.0001), and high frequency of e2 and e4 alleles of the apolipoprotein E gene ( p < 0.005). However, the last significance was lost after the adjustment for age. The incidence of 54Thr allele for intestinal isoform of the fatty acid-binding protein (FABP-2) gene was comparable in all groups. The most important findings were the raised content of saturated FA and the increased activities of Δ 9 and Δ 6 desaturases (all p < 0.0001), and the decreased content of polyunsaturated FA n-6 family and the decreased activity of Δ 5 desaturase (both p < 0.001) in connection with increasing number of MSC. In conclusion, the severity of MS is connected with the progression of oxidative stress and the unfavorable changes in the FA composition. These changes are independent of the studied gene polymorphisms.

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“…A recent study observed that the 1-year migraine prevalence in metabolic syndrome is 11.9 % in men and 22.5 % in women, while several large population-based studies showed a 1-year prevalence of migraine in western countries of 5-5.7 % in men and of 12-17.7 % in women [25][26][27]. Metabolic syndrome has also been associated with chronic pain: a recent study observed that women with fibromyalgia were five times more likely to have metabolic syndrome than healthy controls [28].…”

Section: Metabolic Syndromementioning

confidence: 99%

Migraine and metabolism

Casucci¹,

Villani

Concolino

et al. 2012

Neurol Sci

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Migraine is a chronic disorder with complex pathophysiology involving both neuronal and vascular mechanisms. Migraine is associated with an increased risk of vascular disorders, such as stroke and coronary heart disease. Obesity and diabetes are metabolic disorders with a complex association with migraine. Insulin resistance, which represents the main causal factor of diseases involved in metabolic syndrome, is more common in patients with migraine. A better understanding of the relationship between metabolic syndrome and migraine may be of great clinical interest for migraine management.

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Metabolic syndrome in women with chronic pain

Cited by 95 publications

References 43 publications

Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study

Metabolic syndrome is associated with impaired health-related quality of life: Lapinlahti 2005 study

Severity of Metabolic Syndrome Unfavorably Influences Oxidative Stress and Fatty Acid Metabolism in Men

Migraine and metabolism

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