Metabolic syndrome in Tunisian psoriatic patients: prevalence and determinants

Mebazaa, Abderraouf; Asmi, Monia El; Zidi, Wiem; Zayani, Y.; Rouhou, R Cheikh; Ounifi, S.; Kanoun, F.; Mokni, M; Osman, A. Ben; Feki, Moncef; Slimane, H.; Kaabachi, Naziha

doi:10.1111/j.1468-3083.2010.03856.x

Cited by 56 publications

(62 citation statements)

References 22 publications

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“…Like in our study, there are similar results found by different authors who did not find a high risk of hypertriglyceridemia in Ps [10,20,23,25,26,41,42]. …”

Section: Discussionsupporting

confidence: 81%

“…Since 1987, numerous studies have been conducted to study DL in Ps [1,2,5,6,7,8,9,10,11,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. The results vary since they are based on heterogeneous populations, with or without associated comorbidities, and do not always take into account prescribed medications that can alter the lipid profile or liver function tests [29,30,31,32,33,34,35].…”

Section: Discussionmentioning

confidence: 99%

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Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Santos‐Juanes

Coto-Segura²,

Fernández‐Vega³

et al. 2015

Dermatology

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Background: Psoriasis (Ps) has been associated with an increased incidence of cardiovascular disease. Interesting epidemiological evidence suggests associations between Ps and dyslipidemia (DL), a well-established risk factor for cardiovascular disease. Objective: This study aimed to investigate the association between Ps and multiple measurements of DL, which include levels of triglycerides (TGs), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol (TCh). We also studied the relationship between DL and disease duration. Methods: A prospective hospital-based study was conducted. A total of 661 Caucasian patients with chronic plaque Ps and 661 sex- and age-matched controls were enrolled. Results: Multivariate analysis showed that in psoriatic patients the odds ratio (OR) of TCh >200 mg/dl was 1.406 (95% confidence interval 1.115-1.173), the OR of LDL cholesterol >130 mg/dl was 1.375 (95% confidence interval 1.088-1.738), the OR of HDL cholesterol <40 mg/dl was 0.881 (95% confidence interval 0.599-1.297), and the OR of TGs >150 mg/dl was 1.041 (95% confidence interval 0.783-1.385). We did not find a relationship between lipid levels and disease duration. Conclusion: Based on our population Ps is associated with alterations in TCh and LDL cholesterol, but not in TGs and HDL cholesterol, when ATP III panel levels are used. These alterations are not related to disease duration.

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“…Like in our study, there are similar results found by different authors who did not find a high risk of hypertriglyceridemia in Ps [10,20,23,25,26,41,42]. …”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Santos‐Juanes

Coto-Segura²,

Fernández‐Vega³

et al. 2015

Dermatology

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“…10 Unlike Gisondi et al study which documented the higher prevalence of metabolic syndrome in psoriatic patients than controls after the fourth decade of age, we observed a higher prevalence of metabolic syndrome in all age groups (including age group of 18 to 30 years) in psoriasis patients. 7 Our study has shown that presence of MetS is independent of the extent of involvement (PASI score and BSA involved) which supports previous studies 7,8,11,16 but differs from a Korean study in which MS was found to be significantly more prevalent in patients who had moderate and severe disease. 7,8,11,16,17 Our study denies any correlation between presence of MetS and duration of psoriasis which supports the study by Zidanci et al whereas, Niza and Quazi found higher mean duration of psoriasis when compared to patients with and without metabolic syndrome.…”

Section: Discussionsupporting

confidence: 83%

Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan

et al. 2016

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Background: Psoriasis, a common skin disorder is now considered as systemic inflammatory disease. Its chronic inflammatory state is thought to predispose patients to metabolic syndrome (MetS), which is a significant predictor of cardiovascular events. The objective of the study is to investigate the prevalence of metabolic syndrome in psoriatic patients with only cutaneous involvement and to evaluate the correlation between presence of MetS and psoriasis severityMethods: We performed hospital based, cross-sectional study on 100 adult patients with psoriasis vulgaris and equi-numbered age and sex matched controls. MetS was diagnosed by revised National Cholesterol Education Program’s Adult Panel III criteria.Results: A higher prevalence of metabolic syndrome was found in psoriasis patients as compared to controls [28 (28%) vs 9 (9%), P value=0.0005].Impaired fasting glucose level, hypertension, hypertriglyceridemia and abdominal obesity were more prevalent in psoriasis group. No statistically significant difference was found between prevalence of low levels of HDL and presence of metabolic syndrome. Presence of metabolic syndrome was not associated with severity and duration of psoriasis. Female patients with psoriasis were more frequently having metabolic syndrome.Conclusions: Prevalence of metabolic syndrome is higher in patients with psoriasis irrespective of its duration and severity. This stresses on the need of regular evaluation for the presence of MetS or any of its components in psoriasis patients so as to allow early detection and management.

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“…Similar results were obtained by Nisa et al [49] who observed metabolic syndrome in 28% of patients with psoriasis. Mebazaa et al [50] also observed a higher prevalence of metabolic syndrome in patients with psoriasis than in a control group, although it was not statistically significant. It is worth noting that metabolic syndrome has also been observed in patients with psoriatic arthritis.…”

Section: Introductionmentioning

confidence: 92%

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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Metabolic syndrome in Tunisian psoriatic patients: prevalence and determinants

Abstract: Decreased HDLc is the main biological abnormality that characterized MetS in Tunisian psoriatic patients. Moreover, contrary to men, psoriatic women have shown a significantly higher prevalence of MetS, which is, in addition to decreased HDLc, mainly attributed to abdominal obesity.

Cited by 56 publications

References 22 publications

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia

Prevalence of metabolic syndrome in psoriasis vulgaris: a cross sectional study from a tertiary care hospital of South-East Rajasthan

Biochemical markers of psoriasis as a metabolic disease

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