Metabolic syndrome in people with schizophrenia: a review

Hert, Marc De; Schreurs, Vincent; Vancampfort, Davy; Winkel, Ruud van

doi:10.1002/j.2051-5545.2009.tb00199.x

Cited by 507 publications

(371 citation statements)

References 108 publications

Supporting

Mentioning

332

Contrasting

Unclassified

Order By: Relevance

“…8,[19][20][21][22][23][24][25][26][27][28] Evidence from large clinical samples indicates a high prevalence of metabolic dysfunction in people with serious mental illness, particularly in schizophrenic patients with nearly twice the normal risk of dying from cardiovascular disease. 29 High levels of medication non-compliance are present in a variety of psychiatric disorders, and metabolic side effects, in particular weight gain, could contribute in discontinuing antipsychotic treatment. [30][31][32] This may not be surprising in a society in which thinness is observed as desirable and in which self-esteem is also built on body image.…”

Section: Discussionmentioning

confidence: 99%

Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-β

et al. 2009

View full text Add to dashboard Cite

Atypical antipsychotics (APDs) are currently used in clinical practice for a variety of mental disorders such as schizophrenia, bipolar disorder and severe behavioral disturbances. A well-known disadvantage of using these compounds is a propensity for weight gain, resulting frequently in obesity. The mechanisms underlying pharmacologically induced weight gain are still controversial. The objective of this study was to evaluate in vitro the effects of different APDs on adipogenic events in cultured human pre-adipocytes and in rat muscle-derived stem cells (MDSCs), aiming to identify a common intracellular event contributable to these drugs. Culture behavior was evaluated in terms of cell proliferation, lipid accumulation, gene expression and morphological features. Results indicate that APDs influence adipogenic events through changes in the differentiation and proliferation of preadipocytes and MDSCs that are brought on by protein kinase C-b (PKC-b) activation. These data identify a signaling route that could be a potential target of pharmacological approaches for preventing the weight gain associated with APD treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-β

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Compared with the general population, people with serious mental illnesses (SMI) exhibit higher rates of undiagnosed and untreated medical illnesses and higher morbidity and mortality from physical illnesses, primarily because of modifiable lifestyle risk factors 8 . The poor psychiatric and medical health outcomes in people with SMI may primarily be attributed to disparities in access to, utilization of, and provision of health care [9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Patterns of psychiatric diagnoses in inpatient and outpatient psychiatric settings in Saudi Arabia

Alosaimi

Alzain²,

Asiri³

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

View full text Add to dashboard Cite

Objective: This study aimed to explore the current patterns of psychiatric diagnoses in inpatient and outpatient psychiatric settings in Saudi Arabia. Methods: Cross-sectional study was conducted on patients seeking psychiatric advice at six hospitals in the five main regions of Saudi Arabia. The data were primarily obtained by reviewing patient charts. Results: Total of 1,205 patients were recruited. The majority was unemployed (71.4%), had a low level of education (85.5%), and had low income (61.9%). The most common psychiatric diagnoses among inpatients were schizophrenia (55.8%), bipolar disorder (23.3%) and major depressive disorder (7.2%). The most common psychiatric diagnoses among outpatients were major depressive disorder (29.3%), schizophrenia (28.9%), generalized anxiety disorder (15.6%) and bipolar disorder (11.5%). Primary psychotic disorders and secondary psychiatric disorders were significantly more frequent among men whereas primary bipolar disorders and depressive disorders were significantly more frequent among women in both inpatient and outpatient settings. Psychotic and bipolar disorders were significantly more frequent among younger patients whereas depressive disorders were significantly more frequent among older patients; anxiety disorders were of similar frequency in all age groups. Discussion: The most common psychiatric diagnoses among inpatients were schizophrenia and bipolar disorder whereas the most common psychiatric diagnoses among outpatients were major depressive disorder and schizophrenia.Alosaimi FD et al. / Arch Clin Psychiatry. 2017;44(3):77-83

show abstract

“…Alternative mechanistic explanations of weight gain in schizophrenia have been proposed, focusing more on endocrine factors, histaminergic properties of medication or dysregulation of the hypothalamus (De Hert et al, 2009;Manu et al, 2015). However, this does not negate the usefulness of impaired striatal reward anticipation as a biomarker, as proposed in this review, because there is good evidence that these alternative mechanisms converge on the generation of a valence signal in the striatum (Balodis and Potenza, 2014;Heinz and Schlagenhauf, 2010;Kelley and Berridge, 2002;Rolls, 2009).…”

Section: From Bench To Bedside With the Imaging Biomarker Reward Antimentioning

confidence: 92%

“…They typically concentrate on i) dysregulation of neuroendocrinological circuits (e.g., hormonal regulation by the hypothalamus; Sharma et al, 2014); ii) dysregulation of peripheral hormones (e.g., leptin and ghrelin) implicated in weight homeostasis and in regulation of glucose (De Hert et al, 2009;Mitchell et al, 2013;Sentissi et al, 2008); and iii) the effect of antipsychotic medication on weight (Bak et al, 2014;Deng et al, 2010;Sharma et al, 2014). All of these factors are important.…”

Section: Outlook: Possible New Therapies For Comorbid Obesitymentioning

confidence: 99%

Altered reward anticipation: Potential explanation for weight gain in schizophrenia?

Grimm

Kaiser

Plichta

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

a b s t r a c tObesity and weight gain are severe complications of mental illness, especially schizophrenia. They result from changes in lifestyle and nutrition, side effects of medication and other, less well-understood factors. Recent studies suggest that obesity and weight gain are linked to psychopathology. Specifically, severe psychopathology is associated with greater weight dysregulation, typically weight gain. However, our knowledge about the neuroscientific basis of weight gain in schizophrenia is currently limited. We propose that altered reward anticipation, which in turn is related to striatal dopaminergic dysregulation, may explain why obesity is more prevalent in individuals with mental illness. We review evidence that reward anticipation and weight change are linked by a core deficit in dopaminergic striatal circuits. Several lines of evidence, running from animal studies to preclinical and clinical studies, suggest that striatal dopaminergic neurotransmission is a major hub for the regulation of eating behavior and that dopamine links eating behavior to other motivated behavior. From this perspective, the present review outlines a unifying perspective on dopaminergic reward anticipation as a theoretical frame to link weight gain, medication effects and psychopathology. We derive important but open empirical questions and present perspectives for new therapeutic concepts.

show abstract

Metabolic syndrome in people with schizophrenia: a review

Cited by 507 publications

References 108 publications

Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-β

Weight gain related to treatment with atypical antipsychotics is due to activation of PKC-β

Patterns of psychiatric diagnoses in inpatient and outpatient psychiatric settings in Saudi Arabia

Altered reward anticipation: Potential explanation for weight gain in schizophrenia?

Contact Info

Product

Resources

About