Metabolic syndrome in patients with Alopecia Areata: A case‐control study

Abdollahimajd, Fahimeh; Niknezhad, Nasim; Bahreini, Negin; Younespour, Shima; Namazi, Nastaran

doi:10.1111/dth.14979

Cited by 6 publications

(11 citation statements)

References 19 publications

(54 reference statements)

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“…Abdollahimajd and his colleagues (2021) in Indian population study for AGA described the characteristics and relationship between MetS and CAA plaque. They concluded that there was no significant difference was found in the mean of the cholesterol levels, but two CAA plaques found in the case group which gives a high recommendation to rule out CAA in AGA patients group (Abdollahimajd et al, 2021).…”

Section: Resultsmentioning

confidence: 94%

Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Madhual,

Nayak,

Dalei

et al. 2023

IJERR

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Androgenic alopecia (AGA) is the most common cause of patterned hair loss among males which is characterized by progressive hair loss from the bi-temporal and vertex regions of the scalp. Although previous epidemiological studies found an association between metabolic syndrome (MetS), and cardiovascular disease (CVD) risk among adult AGA male patients, there has been no comprehensive research till now to establish this correlation between AGA and cardiovascular risk and there is a paucity of data regarding this association. Two hundred men were included in the study, N = 100 AGA patients included in the patient group, and the rest in the control group. In both groups, the parameters for MetS such as family history, socioeconomic status, obesity, blood pressure, and lipid profile), and in the presence of the CAA plaques and carotid intima-media thickness (CIMT) using Doppler ultrasonography were established. The degree of AGA was asses by using the Hamilton-Norwood grade (I-VII) system for males. Statistical analysis was performed using the Chi-square test. AGA was found in 11.6% of OPD patients, whereas 3 patients have CAA plaque and 6 cases have C-IMT from the patient's group. There was a statistical association between male AGA with MetS, and insulin-resistant patients (P = 0.001 and 0.0004, respectively). A positive family history of AGA patients, hypertension, DM, and CVD was found to be significantly more frequent in study cases than in the controls (P <0.05). Patients with AGA appear to have a highly prevalent risk of developing CVD and CAA plaque. Therefore, clinical evaluation of each AGA patient’s cases is needed, especially for grade III and above which may help prevent CVD in the future. Timely intervention and lifestyle changes in male AGA patients can fulfil the ultimate objective of reducing cardiovascular complications in the future.

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Section: Resultsmentioning

confidence: 94%

Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Madhual,

Nayak,

Dalei

et al. 2023

IJERR

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“…Additionally, compared to controls, metabolic syndrome has been reported to be higher in patients with AA 16 . Further, in another study by Abdollahimajd et al, although there was no significant association between AA and metabolic syndrome, some of its components were more prevalent in these patients 17 . Insulin resistance is a component of some metabolic syndrome criteria, playing an essential role in its pathophysiology, 18 and AA patients appear to have increased insulin resistance 19–21 …”

Section: Discussionmentioning

confidence: 95%

“…16 Further, in another study by Abdollahimajd et al, although there was no significant association between AA and metabolic syndrome, some of its components were more prevalent in these patients. 17 Insulin resistance is a component of some metabolic syndrome criteria, playing an essential role in its pathophysiology, 18 and AA patients appear to have increased insulin resistance. [19][20][21] There is evidence that immune responses and hair disorders are directly or indirectly linked to metabolic intermediates and lipids in the cholesterol biosynthesis pathway.…”

Section: Discussionmentioning

confidence: 99%

The frequency of fatty liver in patients with alopecia areata: A case–control study

Tehranchinia

Abdollahimajd

Haghighatkhah

et al. 2023

J of Cosmetic Dermatology

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Background Alopecia areata (AA) is an immune‐mediated nonscarring hair loss disorder with multiple subtypes, including alopecia universalis (AU). Previous studies have shown a link between serum lipid profile and alopecia. We aimed to investigate the frequency of fatty liver in patients with AU and patchy alopecia areata (PAA) compared to a control group. Methods This case–control study included patients with AU and PAA referred to a dermatology clinic from September 23, 2019 to September 23, 2020. A group of individuals without hair loss disorders attending the same clinic were selected as controls. Participants' general information, including age, sex, weight, height, and waist circumference (WC), was recorded. Body mass index (BMI) was calculated for all participants. Also, hyperlipidemia and statin use were noted and liver enzymes were evaluated. For AU and PAA patients, disease duration and the Severity of Alopecia Tool (SALT) score were also recorded. Then, all subjects underwent ultrasound to assess fatty liver and its grade. Results Overall, 32 patients were included in each group. All three groups were comparable in age, sex, weight, height, BMI, WC, hyperlipidemia, abnormal liver enzymes, and statin use. Disease duration and SALT score were significantly higher in the AU than in the PAA group (p = 0.009 and p < 0.001, respectively). The frequency of fatty liver was the highest in AU patients (40.6%), followed by 34.4% in PAA patients, and 21.9% in controls (p = 0.263). This was also the case for grade‐1 fatty liver, while grade‐2 was more common in PAA patients, and grade‐3 was only observed in one patient from the AU group (p = 0.496). Conclusions Fatty liver was more frequent in AU and PAA patients than controls, without statistically significant differences. There might be an association between fatty liver and AA, particularly the AU subtype.

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“…Nasimi et al discovered that 20 of 50 patients (54%) with alopecia areata had metabolic syndrome, a considerably greater rate than the 13 (26%) in controls [163]. In contrast, the frequency of metabolic syndrome was not statistically different between AA patients and healthy people in the research of Abdollahimajd et al; nonetheless, AA patients had higher triglyceride levels and lower HDL cholesterol levels [164].…”

Section: Alopecia Areatamentioning

confidence: 95%

The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review

et al. 2022

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Immune-mediated inflammatory skin diseases are characterized by a complex multifactorial etiology, in which genetic and environmental factors interact both in genesis and development of the disease. Nutrition is a complex and fascinating scenario, whose pivotal role in induction, exacerbation, or amelioration of several human diseases has already been well documented. However, owing to the complexity of immune-mediated skin disease clinical course and breadth and variability of human nutrition, their correlation still remains an open debate in literature. It is therefore important for dermatologists to be aware about the scientific basis linking nutrition to inflammatory skin diseases such as psoriasis, atopic dermatitis, hidradenitis suppurativa, bullous diseases, vitiligo, and alopecia areata, and whether changes in diet can influence the clinical course of these diseases. The purpose of this narrative review is to address the role of nutrition in immune-mediated inflammatory skin diseases, in light of the most recent and validate knowledge on this topic. Moreover, whether specific dietary modifications could provide meaningful implementation in planning a therapeutic strategy for patients is evaluated, in accordance with regenerative medicine precepts, a healing-oriented medicine that considers the whole person, including all aspects of the lifestyle.

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Metabolic syndrome in patients with Alopecia Areata: A case‐control study

Cited by 6 publications

References 19 publications

Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

Assessment of cardiovascular risk factors in male androgenetic alopecia: A case control study in a tertiary care hospital of western Odisha

The frequency of fatty liver in patients with alopecia areata: A case–control study

The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review

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