Metabolic syndrome in patients with systemic lupus erythematosus: Association with disease activity, disease damage and age

Mobini, Maryam; Niksolat, Fatemeh; Tahamtan, R A Mohammadpour; Dargahloo, Saeed Dashti; Marzban, Dorsa

doi:10.1111/1756-185x.13276

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…In several studies, SLE patients with dyslipidemia had a higher frequency of glucocorticoid administration, around of 70% [6,35], while in the present study, it was only 31%. In contrast, the antimalarial pharmacotherapy was higher in our study, reaching almost 90% of SLE patients, considering CQ and HCQ administration, while in other studies the combined frequency has been described less than 64% [34,35].…”

Section: Discussioncontrasting

confidence: 92%

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Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Meza-Meza

Shivappa

Montoya‐Buelna

et al. 2020

Preprint

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Background: Systemic lupus erythematosus (SLE) is the prototype autoimmune disease with high inflammatory cytokine levels. In autoimmune conditions, diet could modify the inflammatory status, comorbidities and pharmacotherapy administered in SLE patients. The aim of this study was to assess the relationship of the inflammatory diet status and dietary intake with comorbidities and pharmacotherapy administered in SLE patients. Methods: A cross-sectional study was conducted in sixty-eight Mexican-Mestizo female SLE patients. Dietary intake was estimated from three 24h food records by Nutritionist Pro-Diet software and 27 food parameters were used to evaluate the inflammatory diet status by the normal dietary inflammatory index (DII®). Results: SLE patients presented a global pro-inflammatory diet status (DII: 0.71 ± 1.78). Chloroquine (CQ) administration was related to a pro-inflammatory diet status compared to hydroxychloroquine (HCQ) administration, which was related to an anti-inflammatory diet status (CQ= DII score: 1.385±1.327 vs. HCQ= DII score: 0.004±2.024; p=0.002). CQ administration conferred a pro-inflammatory DII score (β coefficient= 1.20; CI: 1–2.02; R2=0.11; p<0.01) and lower total-cholesterol (β coefficient=-29.2; CI: -4.03 to -54.5; R2=0.07; p<0.05); conversely, HCQ administration conferred an anti-inflammatory DII score (β coefficient= -1.29; CI: -0.46 to -2.12; R2=0.13; p<0.01). SLE patients with CQ administration had lower intake of energy and 12 nutrients evaluated (CQ vs. HCQ; p <0.05), and SLE patients with HCQ treatment had a better achievement ≥100% of daily dietary reference intake (DRI) of energy (HCQ 77% vs. CQ 52%; p=0.03), vitamin A (HCQ 65% vs. CQ 29%; p<0.01), cholesterol (HCQ 29% vs. CQ 3%; p<0.01), and fiber (HCQ 26% vs. CQ 6%; p=0.03).Conclusions: In SLE patients the CQ administration was related to a pro-inflammatory diet status and low total-cholesterol, and HCQ administration with an anti-inflammatory diet status and better dietary intake.

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Section: Discussioncontrasting

confidence: 92%

“…However, in our study, SLE patients presented normal serum levels of lipid pro le, with lower levels of TG, TC, and LDL-C compared with other studies performed in SLE patients [6,33,34]. Serum HDL-C levels in the present study were found within the normal range with higher values compared to other studies [6,33].…”

Section: Discussioncontrasting

confidence: 73%

Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Meza-Meza

Shivappa

Montoya‐Buelna

et al. 2020

Preprint

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“…Notably, it has been reported that obese SLE patients have increased gene and protein expression of several pro-inflammatory cytokines such as IL-23 [45] and TNF-α, associated with total fat mass in pediatric SLE patients [46]. This inflammation status associated with obesity creates a background with an increased likelihood to develop complications such as metabolic syndrome in SLE patients [47,48]. In experimental studies, it has been suggested that high levels of adipocytokines such as leptin could be related to the development of autoimmunity in obese SLE-prone mice [49,50].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

et al. 2019

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Obesity and nutrients intake deficiencies may contribute to the clinical manifestations and inflammatory processes in systemic lupus erythematosus (SLE). The aim of this study was to assess the relationship between nutritional status and dietary intake with clinical variables in Mexican-mestizo SLE patients. A cross-sectional study was conducted in 130 female SLE patients, classified by the 1997 SLE American College of Rheumatology (ACR) criteria; the clinical activity was evaluated by the Mexican-Systemic Lupus Erythematosus-Disease Activity Index (Mex-SLEDAI); body mass index (BMI) by the World Health Organization (WHO) criteria; the energy calculation and nutritional intake were performed by Nutritionist Pro Diet software. SLE patients with excess weight (BMI > 25 kg/m2) showed a higher score of clinical activity (Mex-SLEDAI = 2; p = 0.003), higher clinical activity prevalence (40.9%; p = 0.039) and a significant association for high clinical activity (odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.08–5.9; p = 0.033), in comparison with patients without excess weight (BMI < 25 kg/m2). In particular, the excess weight increased the Mex-SLEDAI score (β coefficient = 1.82; R2 = 0.05; p = 0.005). Also, the SLE patients presented a high prevalence (%) of deficient consumption (cut-off point: <67% of dietary adequacy) of vitamin E (100%), iodine (96%), omega 3 (93.44%), biotin (78%), vitamin K (73.33%), iron (67%), vitamin D (63.3%), potassium (59%), folic acid (56.67%), pantothenic acid (43.3%), vitamin A (41.67%) and zinc (32%). In conclusion, in SLE patients the excess weight was associated with increased clinical activity and to the presence of deficiencies in some essential nutrients ingested.

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“…Nevertheless, the metabolic abnormalities of other immune cells are less understood in SLE. Increased occurrences of metabolic syndrome are observed among lupus patients, which is closely related to both atherosclerosis and multiple organ injury [ [7] , [8] , [9] , [10] ]. Metabolomics demonstrate that intermediates related to main metabolic pathways were altered in patients with SLE by analyzing blood and urine samples [ [11] , [12] , [13] ].…”

Section: Introductionmentioning

confidence: 99%

Immunometabolism in the pathogenesis of systemic lupus erythematosus

Zhang

Wang²,

Yin

et al. 2020

Journal of Translational Autoimmunity

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Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by chronic inflammation and pathogenic auto-antibodies. Apart from B cells, dysregulation of other immune cells also plays an essential role in the pathogenesis and development of the disease including CD4 + T cells, dendritic cells, macrophages and neutrophils. Since metabolic programs control immune cell fate and function, they are critical checkpoints in an effective immune response and are involved in the etiology of autoimmune disease. In addition, mitochondria and oxidative stress are both involved in cellular metabolism and is also essential in immune response. In this review, apart from the disturbed immune system, we will discuss mitochondrial dysfunction, oxidative stress, abnormal metabolism (including glucose, lipid and amino acid metabolism) of immune cells as well as epigenetic control of metabolism reprogramming to elucidate the underlying pathogenic mechanisms of systemic lupus erythematosus.

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Metabolic syndrome in patients with systemic lupus erythematosus: Association with disease activity, disease damage and age

Abstract: The frequency of MetS was not significantly different from that of the control group, but almost half of the patients were found with this syndrome. This calls for further follow up and appropriate treatment of patients with MetS.

Cited by 17 publications

References 27 publications

Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Relationship of the Inflammatory Diet Status and Dietary Intake with Antimalarial Treatment in Systemic Lupus Rrythematosus: A Cross-Sectional Study

Relationship of Excess Weight with Clinical Activity and Dietary Intake Deficiencies in Systemic Lupus Erythematosus Patients

Immunometabolism in the pathogenesis of systemic lupus erythematosus

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