Metabolic Syndrome in Overweight and Obese Japanese Children

Yoshinaga, Masao; Tanaka, Satoru; Shimago, Atsushi; Sameshima, Koji; Nishi, Junichiro; Nomura, Yoshio; Kawano, Yoshifumi; Hashiguchi, Jun; Ichiki, Takeo; Shimizu, Shinichiro

doi:10.1038/oby.2005.134

Cited by 68 publications

(70 citation statements)

References 19 publications

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“…16 There were some data from Japan and USA. The prevalence of MS was 17.7% in Japanese obese elementary school children aged between 6 and 11 years old, 17 and 28.7% in USA in the obese adolescents aged between 12 and 19 years old, 18 and 38.7%…”

Section: Discussionmentioning

confidence: 96%

Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention

Liang

Zou

et al. 2006

Int J Obes

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Objective: We aimed to evaluate the prevalence of metabolic syndrome (MS) in a group of obese children and adolescents in Zhejiang in the south of China, and to compare risk factors such as insulin resistance, adiponectin level and impaired glucose tolerance (IGT) etc with that of simple obese group (SOB) and non-obese healthy group, and also to evaluate the effect of metformin and lifestyle intervention in MS group by up to a 3-month follow-up. Methods: Three hundred and forty eight moderately or severely obese adolescents aged between 7 and 16 years were enrolled. Oral glucose tolerance test (OGTT), biochemical indicators, blood pressure and body mass index (BMI) were assessed in all of them. Three subgroups were selected (MS group, SOB and healthy control). Adiponectin levels, Whole body insulin sensitive index (WBISI), homeostasis model of insulin resistance (HOMA-IR), plasma lipid and blood pressure were compared in these three groups. Thirty out of thirty-six MS subjects with age over 10 years received metformin treatment combined with lifestyle modification. Results: (1) The prevalence of MS was 10.34% among all obese subjects, which increased with the severity of obesity and reached 22.1% in severely obese children and adolescents. The occurrence of more than one complication reached 72.13%. The incidence of type 2 diabetes and IGT were 1.44 and 1.44% respectively. (2) BMI, waist-to-hip ratio (WHR) and HOMA-IR increased stepwise in the control group, SOB and MS group, whereas serum adiponectin and WBISI decreased stepwise (all Po0.01). Systolic pressure, triglyceride, total cholesterol, low-density lipoprotein cholesterol and postprandial 2-h blood glucose in the MS group increased significantly compared to those in control and SOBs (all Po0.01). A correlation analysis showed that serum levels of adiponectin and WBISI were associated with the components of MS (all Po0.05). (3) After metformin and lifestyle intervention, clinical symptoms were ameliorated, serum adiponectin levels were actually increased and HOMA-IR was dropped in 20/30 MS children who had finished a 3-months follow-up (all Po0.01). Conclusion: The prevalence of MS in severely obese children and adolescents in Zhejiang area has reached a high level. Insulin resistance and hypoadiponectinemia were found in these MS children. Metformin combined with lifestyle modification was confirmed to be efficient and safe in treating the obese adolescents with MS.

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Section: Discussionmentioning

confidence: 96%

Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention

Liang

Zou

et al. 2006

Int J Obes

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“…In addition, the criteria for assessing the metabolic syndrome in children and adolescents is not well established, as few studies have been done (4,5,(62)(63)(64)(65).…”

Section: Study Limitationsmentioning

confidence: 99%

High rates of the metabolic syndrome in a First Nations Community in western Canada: prevalence and determinants in adults and children.

Kaler

Ralph-Campbell

Pohar

et al. 2006

International Journal of Circumpolar Health

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Objectives. Increasing type 2 diabetes in Aboriginal communities across North America raises concerns about metabolic syndrome in these populations. Some prevalence information for American Indians exists, but little has been available for Canada's First Nations. Study Design. We screened 60 % of the eligible population of a single First Nation in Alberta for diabetes, prediabetes, cardiovascular risk, and metabolic syndrome. Methods. NCEP/ATP III and IDF criteria were used to identify metabolic syndrome in participants aged ≥ 18; modified NCEP/ATP III criteria were used for participants aged < 18. Logistic regression identified factors associated with the metabolic syndrome. Results. 297 individuals were screened (176 adults, 84 children/adolescents, with complete data). 52.3 % of adults had metabolic syndrome using NCEP/ATP III criteria, and 50 % using IDF criteria. 40.5 % of individuals aged < 18 had the condition. Waist circumference was the most prevalent correlate. Bivariate analysis suggested that age, BMI, weight, A1c, LDL-C, ADA risk score and activity pattern were associated with metabolic syndrome. Conclusions. Our data represent the first available for Western Cree and are consistent with prevalence reported for Aboriginal populations in Ontario and Manitoba. High rates of obesity, pre-diabetes and metabolic syndrome for participants aged < 18 raise concerns about future prevalence of diabetes and cardiovascular disease.

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“…The prevalence of the metabolic syndrome in overweight Japanese children was virtually identical to the prevalence of the metabolic syndrome in overweight children in the United States. 10 Abdominal obesity increased the risk of developing arterial hypertension by 2.33-times in the Tanno-Sobetsu study. 11 Moreover, in this rural population, subjects fulfilling metabolic syndrome criteria exhibited a 2.2-times greater risk of developing cardiac disease compared with subjects without the metabolic syndrome.…”

Section: The Global Obesity Burden-spotlight On Japanmentioning

confidence: 94%