Metabolic Syndrome in Offspring of Parents with Metabolic Syndrome: A Meta-Analysis

Laurent, Irakoze; Manirakiza, Astère; Liu, Juncheng; Li, Jiayu; Liliane, Nkengurutse; Deng, Shuhua; Xiao, Xiaoqiu

doi:10.1159/000513370

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…Several studies have demonstrated that cardiovascular risk factors can be inherited across generations, 13 , 19 , 26 , 27 , 28 , 29 , 30 , 31 highlighting the potential of parental nonideal CVH to predict nonideal CVH in their offspring. 10 , 18 However, there have been limited investigations into the sex‐specific associations of CVH between parents and their children.…”

Section: Discussionmentioning

confidence: 99%

“… 10 , 18 However, the majority of studies investigating familial correlation in terms of CVH as a structure or some individual CVH metric focused only on the maternal and paternal effects on the offspring. 10 , 19 This study aimed to describe the sex‐specific association between parents and their adult offspring with respect to CVH, using a Korean national representative survey. We also estimated the sex‐specific association of the parent–offspring relationship for each CVH metric.…”

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confidence: 99%

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Parent–Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey

Hoang,

Jung,

Lee

et al. 2024

JAHA

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Background Studies have reported the strength of cardiovascular health (CVH) metrics in parent–offspring relationships. This study aimed to describe the sex‐specific associations between CVH in parents and adult offspring. Methods and Results This study was conducted on the Korea National Health and Nutrition Examination Survey data set, which analyzed trios of mother–father–child, with the child's age from 20 to 39 years. To use the nature of sampling design, survey weighting was applied to all our analyses. Ideal CVH was defined as a cluster of at least 5 ideal individual CVH metrics. We examined the association between parents and their adult offspring regarding clustering CVH and individual CVH metrics through odds ratios and 95% CIs using multiple logistic regression with standard errors adjusted for within‐family clustering. The study included 1267 married couples comprising 748 sons and 819 daughters. After adjusting for household income and offspring's sex, age, education, and alcohol consumption, an offspring with either parent attaining a nonideal CVH was 3.52 times more likely to have nonideal CVH. Fathers' nonideal CVH was significantly positively associated with the daughters' nonideal CVH. Maternal nonideal CVH was significantly positively associated with the son's nonideal CVH. When analyzing individual CVH metrics, ideal status in fathers or mothers reduced the likelihood of their offspring having a nonideal status. Conclusions This cross‐sectional study showed positive and differential associations of CVH and its components between parents' and offsprings' nonideal status. Our hypothesis‐generating results suggest the relevance of using CVH as a composite indicator in family‐centered approaches and heart‐health interventions.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Parent–Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey

Hoang,

Jung,

Lee

et al. 2024

JAHA

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“…In a cohort study, the odds ratio of hepatic steatosis in at least one parent with hepatic steatosis was 2.0, whereas that of both parents with hepatic steatosis was 6.4 ( 8 ). In a meta–analysis study, the association of pediatric MetS with maternal MetS was stronger than that of paternal MetS, and that with both parents was strongest ( 45 ). The stronger lifestyle associations of children with mothers than those with fathers might be related to this difference.…”

Section: Discussionmentioning

confidence: 99%

Parental metabolic syndrome and elevated liver transaminases are risk factors for offspring, even in children and adolescents with a normal body mass index

Song,

Yang,

Lee

et al. 2023

Front. Nutr.

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IntroductionThe parent–child correlation in metabolic syndrome (MetS) and elevated transaminases is sparsely researched. We assessed the correlation of parental MetS and elevated transaminase status with these conditions in their children.MethodsData of 4,167 youths aged 10–18 years were analyzed in a population-based survey, and the parental characteristics were stratified by the presence or absence of MetS or alanine aminotransferase (ALT) elevation in their children. The prevalence of these conditions in children was analyzed according to their parents’ status. Logistic regression analyses were performed with MetS and ALT elevation in youth as the dependent variables.ResultsThe proportions of MetS and ALT elevation were higher in parents of children with MetS and ALT elevation than in those without, even among youths without obesity. In logistic regression analyses, age, body mass index–standard deviation score (BMI–SDS), and ALT elevation were positively associated with MetS, whereas age, male sex, BMI–SDS, protein intake, and MetS were positively associated with ALT elevation. Higher protein intake was related to ALT elevation, whereas metabolic components and nutritional factors were closely related in parents and their children. Odds ratios (OR) of ALT elevation for MetS was 8.96 even after adjusting nutritional factors in the children. The OR was higher for ALT elevation in the children of parents with MetS and ALT elevation compared to those without. ORs for MetS and ALT elevation in the children of parents with MetS were higher than those of children of parents without MetS, even after adjusting for nutritional intake. ORs for ALT elevation were higher in the children of parents with ALT elevation than those without, even after adjusting for nutritional intake and BMI of parents as well as the nutritional intake, age, sex, and BMI–SDS of the children.ConclusionMetS and elevated liver transaminase statuses in children were associated with those of their parents even after adjusting for nutritional factors, and the relationships were more prominent in the youth without obesity.

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“… 12 Cohort studies indicate that male obesity likely has epigenetic effects and transgenerational consequences. 13 …”

Section: Introductionmentioning

confidence: 99%

Impact of bariatric surgery, lifestyle change, and pharmacotherapy on fertility in men with obesity: a systematic review protocol

Peel,

Mathews,

Vincent

et al. 2024

JBI Evidence Synthesis

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Objective: This review will determine whether various health interventions designed to reduce weight (lifestyle change, bariatric surgery, pharmacotherapy) in men with obesity are associated with improved fertility markers. The review will also establish whether the degree of weight loss achieved through these methods is associated with improvement. Background: Current preconception guidelines provide limited information for men with obesity. Small studies implementing lifestyle changes in men are associated with improvement in sperm quality, whereas bariatric surgery has not been associated with improvements in sperm quality. Determining the benefit of different interventions and the relationship to weight lost is necessary to optimize male fertility. Inclusion criteria: The population will be men < 50 years who are either overweight (BMI > 25 kg/m2) or obese (BMI > 30 kg/m2). The exposure of interest will be an intervention undertaken to improve health or reduce weight, categorized as lifestyle change, bariatric surgery, or pharmacotherapy. Outcomes will include time to conception, fecundity rate, assisted reproduction outcomes, and semen quality measures. Secondary analysis will determine whether degree of weight loss achieved is associated with degree of improvement. Methods: This review will follow the JBI methodology for systematic reviews of etiology and risk. Databases to be searched will include PubMed, Embase (Ovid), Cochrane Central Register of Controlled Trials, Web of Science, and Scopus. Articles not translated into English will be excluded. Methodological quality will be assessed using the JBI critical appraisal tools. Data will be extracted using a standardized tool developed by the reviewers. Statistical meta-analysis will be performed where possible to synthesize outcomes of similar methods. Review registration number: PROSPERO CRD 42022349665

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Metabolic Syndrome in Offspring of Parents with Metabolic Syndrome: A Meta-Analysis

Cited by 12 publications

References 31 publications

Parent–Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey

Parent–Offspring Associations of Ideal Cardiovascular Health Metrics: Findings From the 2014 to 2021 Korea National Health and Nutrition Examination Survey

Parental metabolic syndrome and elevated liver transaminases are risk factors for offspring, even in children and adolescents with a normal body mass index

Impact of bariatric surgery, lifestyle change, and pharmacotherapy on fertility in men with obesity: a systematic review protocol

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