Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors

Vuković, Rade; Zdravković, Dragan; Mitrovic, Katarina; Milenković, Tatjana; Todorović, Sladjana; Vuković, Ana; Soldatović, Ivan

doi:10.1515/jpem-2014-0533

Cited by 7 publications

(9 citation statements)

References 34 publications

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“…A history of a cardiovascular disease, diabetes, obesity, and hypertension in the family was present in a significant number of children in this study. This might have added to the increased prevalence of MS in the study population as shown in previous studies (14,18,25). Insulin resistance was more common in children with MS.…”

Section: Discussionmentioning

confidence: 74%

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Metabolic Syndrome and Insulin Resistance in Schoolchildren From a Developing Country

et al. 2020

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Background: Overweight and obesity are prevalent in schoolchildren due to dietary habits and lack of exercise. These children are prone to metabolic syndrome (MS) and future risk of type 2 diabetes mellitus and cardiovascular diseases. Materials and Methods: This cross-sectional study was conducted in Bhubaneswar City, Eastern India, among schoolchildren. Obesity and overweight were determined by the Indian Academy of Pediatrics guideline. Fasting venous blood samples were taken for insulin, blood glucose, and lipid levels measurement. Blood pressure was measured as per the protocol. The International Diabetic Federation (IDF) criteria for the definition of MS were followed. Insulin resistance was determined by a homeostatic model assessment (HOMA-IR). Results: A total of 1,930 children were screened, of which 545 (28.2%) were overweight and obese. The male to female ratio was 1.27. The overall prevalence of MS was 21.8% (11% in 6 to ≤10 years old and 30.6% in 11 to 16 years old). A history of cardiovascular disease, diabetes, obesity, and hypertension in the family was present in 42.7%. Acanthosis nigricans was present in 46.4%. A history of exclusive breast feeding for 6 months was present in 68.1%. The mean HOMA-IR in children with MS was 5.46 compared to 2.18 in those without MS (insulin resistance was more common in children with MS). Conclusions: The present study found a higher prevalence of MS and insulin resistance in schoolchildren from Eastern India who are overweight/obese.

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Section: Discussionmentioning

confidence: 74%

“…There have been various studies published worldwide on the prevalence of MS in children and adolescents (10, [14][15][16][17][18][19][20][21][22][23][24][25]. These are mainly hospital-based studies, with few being conducted in school or community settings (10, 16,[19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Insulin Resistance in Schoolchildren From a Developing Country

et al. 2020

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“…Methodology used was similar to our previous research of metabolic comorbidities in the obese youth [ 21 , 22 ]. BMI percentiles and standard deviation scores (SDS) were calculated in accordance with WHO growth reference charts using WHO Anthro and AnthroPlus software and waist circumference percentiles (WC) according to the reference values by Fernandez et.…”

Section: Methodsmentioning

confidence: 99%

Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics

et al. 2017

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BackgroundThe dichotomous nature of the current definition of metabolic syndrome (MS) in youth results in loss of information. On the other hand, the calculation of continuous MS scores using standardized residuals in linear regression (Z scores) or factor scores of principal component analysis (PCA) is highly impractical for clinical use. Recently, a novel, easily calculated continuous MS score called siMS score was developed based on the IDF MS criteria for the adult population.ObjectiveTo develop a Pediatric siMS score (PsiMS), a modified continuous MS score for use in the obese youth, based on the original siMS score, while keeping the score as simple as possible and retaining high correlation with more complex scores.Subjects and methodsThe database consisted of clinical data on 153 obese (BMI ≥95th percentile) children and adolescents. Continuous MS scores were calculated using Z scores and PCA, as well as the original siMS score. Four variants of PsiMS score were developed in accordance with IDF criteria for MS in youth and correlation of these scores with PCA and Z score derived MS continuous scores was assessed.ResultsPsiMS score calculated using formula: (2xWaist/Height) + (Glucose(mmol/l)/5.6) + (triglycerides(mmol/l)/1.7) + (Systolic BP/130)—(HDL(mmol/l)/1.02) showed the highest correlation with most of the complex continuous scores (0.792–0.901). The original siMS score also showed high correlation with continuous MS scores.ConclusionPsiMS score represents a practical and accurate score for the evaluation of MS in the obese youth. The original siMS score should be used when evaluating large cohorts consisting of both adults and children.

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“…There is a wide opinion that the rising prevalence of obesity is connected with the growing number of early complications in children and adolescents, such as type 2 diabetes mellitus (T2D) and metabolic syndrome (MS) [ 1 , 10 , 11 ]. MS is defined as a cluster of cardiovascular risk factors: impaired glucose tolerance, dyslipidemia (elevated triglycerides and low high-density lipoprotein cholesterol (HDL)), hypertension, and abdominal obesity [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The International Diabetes Federation (IDF) in 2007 issued a unifying definition of MS in children and adolescents, and this progress enabled the comparison of different studies in the future [ 20 ]. Many studies are published on the prevalence and impact of the MS in the adult population, but there is limited information on the epidemiology of MS in children and adolescents, especially in Eastern Europe and the Mediterranean area [ 10 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Metabolic Syndrome and Cardiovascular Risk Factors in Obese Children and Adolescents in Dalmatia: A Hospital Based Study

Šimunović

Božić

Milić

et al. 2016

International Journal of Endocrinology

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Obesity and metabolic syndrome (MS) are one of the biggest public health issues in child and adolescent population. To the best of the authors' knowledge, this hospital based study is the first report on the prevalence of MS in obese children and adolescents in Dalmatia, the Mediterranean part of Croatia. The objectives of this study were to determine the prevalence of individual cardiovascular risk factors and MS. Between January 2009 and June 2014, 201 obese subjects aged 6 to 18 were analyzed retrospectively from our Pediatric Endocrine Unit database. The subjects were then classified in two groups of obesity; subjects with BMI z score 2.0–3.0 were classified as moderately obese and subjects with BMI z score > 3.0 were classified as severely obese. The overall prevalence of MS using the modified IDF criteria was 30.3%. The most common component of MS in both groups was arterial hypertension, while impaired fasting glucose was the least common component of MS. Our finding of high prevalence of MS underlines the importance of early childhood obesity treatment.

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Metabolic syndrome in obese children and adolescents in Serbia: prevalence and risk factors

Abstract: High prevalence of MS emphasizes the need for prevention and treatment of childhood obesity.

Cited by 7 publications

References 34 publications

Metabolic Syndrome and Insulin Resistance in Schoolchildren From a Developing Country

Metabolic Syndrome and Insulin Resistance in Schoolchildren From a Developing Country

Pediatric siMS score: A new, simple and accurate continuous metabolic syndrome score for everyday use in pediatrics

The Prevalence of Metabolic Syndrome and Cardiovascular Risk Factors in Obese Children and Adolescents in Dalmatia: A Hospital Based Study

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