Metabolic Syndrome in Japanese Patients with Obstructive Sleep Apnea Syndrome

Sasanabe, Ryujiro; Banno, Katsuhisa; Otake, Kazuo; Hasegawa, Rumiko; Usui, Kengo; Morita, Mikiko; Shiomi, Toshiaki

doi:10.1291/hypres.29.315

Cited by 106 publications

(91 citation statements)

References 30 publications

(25 reference statements)

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“…The prevalence of MetS associated with nocturnal intermittent hypoxia was 2 to 3-fold higher for persons with a ODI of 5 to 15 and 4 to 5-fold higher for persons with an ODI of ≥ 15 compared with those with an ODI of 5. The magnitude of these associations was similar to those in previous studies of American and Chinese [7][8][9] . As for the components of MetS, previous studies reported that nocturnal intermittent hypoxia was associated with .…”

Section: Discussionsupporting

confidence: 89%

“…The prevalence of MetS defined by the Adult Treatment Panel guidelines of the National Cholesterol Education Program (NCEP/ ATP ) was 2-fold higher among patients with an apnea-hypopnea index (AHI) ≥ 5 than among those with AHI 5 7,8) , 2-to 4-fold higher among those with AHI ≥ 15 than among those with AHI 15 8,9) , and 9-fold higher among those with AHI ≥ 15 and OSA-related symptoms (e.g. excessive daytime sleepiness) than among those without either 10) .…”

Section: Introductionmentioning

confidence: 99%

“…Vgontzas and colleagues suggested that MetS manifests as OSA, because of the association of MetS with increased oxidative stress, insulin resistance and increased levels of cytokines, which are also associated with OSA 11,12) . However, since most previous studies recruited mainly obese or overweight subjects (body mass index, BMI; 25.9 − 38.4 kg/m 2 ) [7][8][9][10][11] , and both OSA and MetS were strongly associated with BMI, prior findings may not be applicable to non-overweight populations.…”

Section: Introductionmentioning

confidence: 99%

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Nocturnal Intermittent Hypoxia and Metabolic Syndrome; the Effect of being Overweight: the CIRCS Study

Muraki

Tanigawa

Yamagishi

et al. 2010

JAT

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Aim:We investigated whether nocturnal intermittent hypoxia, a surrogate marker for obstructive sleep apnea, is associated with metabolic syndrome and its components among Japanese. Methods: We examined 1,710 male and 2,896 female community-dwelling Japanese aged 40 to 69, who participated in annual cardiovascular examinations and investigations of sleep. Nocturnal intermittent hypoxia was estimated based on a 3% oxygen desaturation index measured with pulse-oximetry during sleep. No, mild and moderate-to-severe nocturnal intermittent hypoxia were defined by 5, 5 to 15 and ≥ 15 events/hour, respectively. Metabolic syndrome was defined by modified criteria of the Adult Treatment Panel guidelines. Results: Compared with no nocturnal intermittent hypoxia, the multivariable odds ratio of metabolic syndrome was 1.9 (95% confidence interval: 1.6 − 2.4) for mild and 3.2 (2.2 − 4.7) for moderate-tosevere nocturnal intermittent hypoxia among men; 2.6 (2.1 − 3.4) and 5.8 (3.4 − 9.8) among women, respectively. When stratified by overweight status (body mass index ≥ 25 kg/m 2 ), the multivariable odds ratio of two or more metabolic risk factors (other than overweight) associated with moderateto-severe nocturnal intermittent hypoxia was 1.9 (1.2 − 3.1) among non-overweight subjects and 1.4 (0.9 − 2.1) among overweight subjects (p for interaction 0.002). Conclusions: Nocturnal intermittent hypoxia was associated with the accumulation of metabolic risk factors, especially among non-overweight individuals.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nocturnal Intermittent Hypoxia and Metabolic Syndrome; the Effect of being Overweight: the CIRCS Study

Muraki

Tanigawa

Yamagishi

et al. 2010

JAT

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“…3). MetS is diagnosed in clinical practice by the NCEP-ATP (National Cholesterol Education ProgrammeAdult Treatment Panel) III criteria, which require the presence of three out of five criteria [36][37][38][39][40][41][42][43][44][45]. The number of MetS criteria is defined as the metabolic index and can be used as an indicator of severity of metabolic abnormalities.…”

Section: Osa Visceral Fat and The Metabolic Syndromementioning

confidence: 99%

Sleep apnoea and metabolic dysfunction

Bonsignore¹,

Borel²,

Machan³

et al. 2013

European Respiratory Review

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Obstructive sleep apnoea (OSA) is a highly prevalent condition often associated with central obesity. In the past few years, several studies have analysed the potential independent contribution of OSA to the pathogenesis of metabolic abnormalities, including type 2 diabetes, the metabolic syndrome and nonalcoholic fatty liver disease. New perspectives in OSA patient care have been opened by the promotion of lifestyle interventions, such as diet and exercise programmes that could improve both OSA and the metabolic profile. The rich clinical literature on this subject, together with the growing amount of data on pathophysiological mechanisms provided by animal studies using the chronic intermittent hypoxia model, urged the organising Committee of the Sleep and Breathing meeting to organise a session on sleep apnoea and metabolic dysfunction, in collaboration with the European Association for the Study of Diabetes. This review summarises the state-of-the-art lectures presented in the session, more specifically the relationship between OSA and diabetes, the role of OSA in the metabolic consequences of obesity, and the effects of lifestyle interventions on nocturnal respiratory disturbances and the metabolic profile in OSA patients. @ERSpublications Treatment of obesity and metabolic diseases through diet and exercise should be part of OSA management besides CPAP

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“…In addition to elevated risk for CVD, MetS has been reported to be associated with diabetes mellitus (Ford et al 2008), chronic kidney disease (Ninomiya et al 2006), obstructive sleep apnea syndrome (Sasanabe et al 2006), and even mental disorders such as depression (Takeuchi et al 2009). In Japan, the Ministry of Health, Labour and Welfare estimated in 2007 that 7.6 million Japanese men (27%) and 2.9 million Japanese women (10%) aged 40-74 years met the criteria for a diagnosis of MetS (Ministry of Health, Labour and Welfare 2010).…”

mentioning

confidence: 99%

Lack of Leisure-Time Physical Activity in Non-Obese Japanese Men with Components of Metabolic Syndrome

Inoue

Nakao

Nomura

et al. 2011

Tohoku J. Exp. Med.

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A focus exclusively on waist circumference, the main component used in the diagnosis of metabolic syndrome (MetS), may lead to ignoring non-obese individuals with other MetS components, including high levels of blood pressure, fasting blood glucose, and triglycerides and low levels of high-density lipoprotein. This study investigated lifestyles and eating behaviors among non-obese individuals with components of MetS. Of the 918 Japanese male workers, 151 subjects (16.4%) had a waist circumference < 85 cm with more than one MetS component. This non-obese high-risk group for MetS gained weight in adulthood, consume alcohol, and engage in less leisure-time physical activity compared to 317 subjects (34.5%) with a waist circumference < 85 cm and without MetS components (p < 0.05). The remaining 450 subjects (49%) were obese with a waist circumference ≥ 85, including 93 men with MetS. A lack of leisure-time physical activity was associated with the non-obese high-risk group for MetS [odds ratio 1.59, 95% confidence interval 1.02 -2.49] compared to the 317 non-obese men without MetS (reference group). Such a difference in physical activity was not found between the 450 obese subjects and the reference group. Instead, eating behaviors, such as eating rapidly, preference for fatty foods, and eating out for dinner, were significantly associated with MetS. Thus, men with smaller waist circumferences and any MetS component should be carefully monitored for physical activity to prevent further development of MetS, while men with larger waist circumferences including MetS need to be monitored for unfavorable eating behaviors.

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Metabolic Syndrome in Japanese Patients with Obstructive Sleep Apnea Syndrome

Cited by 106 publications

References 30 publications

Nocturnal Intermittent Hypoxia and Metabolic Syndrome; the Effect of being Overweight: the CIRCS Study

Nocturnal Intermittent Hypoxia and Metabolic Syndrome; the Effect of being Overweight: the CIRCS Study

Sleep apnoea and metabolic dysfunction

Lack of Leisure-Time Physical Activity in Non-Obese Japanese Men with Components of Metabolic Syndrome

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