Metabolic Syndrome in HIV-Infected Patients from an Urban, Midwestern US Outpatient Population

Mondy, Kristin; Overton, Edgar Turner; Grubb, Jessica R.; Tong, Shao; Seyfried, Warren; Powderly, William G.; Yarasheski, Kevin E.

doi:10.1086/511679

Cited by 181 publications

(206 citation statements)

References 30 publications

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“…In our study we have found increase in total cholesterol, triglyceride, LDL, VLDL which is consistent with previous study done by Buchacz et al 13 Mondy et al has reported increased level of triglyceride which is consistent with our finding but they reported low levels of total cholesterol and LDL. 12 In present study HDL was low and this is consistent with other studies by Pariad et al, Buchacz et al, Khiangte et al, Mondy et al and G Shor Posner et al [10][11][12][13]25 Khiangte et al showed deranged lipid profile in their HIV patients and in them LDL levels decreased as CD4 count decreased which is consistent with our observation. However LDL decreases while triglyceride and VLDL increases with decrease in CD4 count in their study.…”

Section: Discussionsupporting

confidence: 93%

“…10,11 Various studies have shown different prevalence and pattern of dyslipidaemia. [10][11][12][13] Infection can increase serum triglyceride (TG) level by decreasing the clearance of circulating lipoprotein, which thought to be due to reduced lipoprotein lipase or by stimulating lipid synthesis in liver through increase in either hepatic fatty acid synthesis or re-esterification of fatty acid derived from lipolysis. 14 Multiple pathogenic mechanisms by which HIV virus leads to dyslipidaemia have been hypothesized but they are still controversial.…”

Section: Introductionmentioning

confidence: 99%

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Pattern of dyslipidaemia in human immunodeficiency virus infected patients- a study from rural tertiary care hospital in central India

et al. 2016

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Pattern of dyslipidaemia in human immunodeficiency virus infected patients- a study from rural tertiary care hospital in central India

et al. 2016

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“…estimaram que 30% dos adultos em uma área rural do Nordeste brasileiro (não infectados por HIV, idade média 49 anos) fossem portadores de SM, pelos critérios do NCEP-ATPIII (28 (8). A nosso ver, as discrepâncias entre os resultados dos diversos estudos não permitem, ainda, concluir se há aumento do risco de SM entre indivíduos com HIV, mas esse risco não parece estar associado à TARV ou à duração da infecção (8,31).…”

Section: Diehl Et Alunclassified

Prevalência da lipodistrofia associada ao HIV em pacientes ambulatoriais brasileiros: relação com síndrome metabólica e fatores de risco cardiovascular

Diehl¹,

Dias²,

Paes³

et al. 2008

Arq Bras Endocrinol Metab

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RESUMOA lipodistrofia associada ao HIV (LAHIV) acomete 40% a 50% dos pacientes infectados pelo vírus, mas sua prevalência no Brasil é desconhecida. O objetivo deste trabalho foi avaliar a prevalência de LAHIV entre adultos brasileiros infectados, bem como sua relação com fatores de risco cardiovascular e sín-drome metabólica (SM). Foram avaliados 180 pacientes maiores de 18 anos, infectados por HIV, atendidos no Ambulatório de Infectologia da Universidade Estadual de Londrina. Por meio de entrevista e revisão de prontuário, foram avaliados dados antropométricos, pressão arterial, antecedentes mór-bidos pessoais e familiares, duração da infecção por HIV e da aids, drogas anti-retrovirais utilizadas, CD4+, carga viral, glicemia e perfil lipídico. A LAHIV foi definida como a presença de alterações corporais percebidas pelo próprio paciente e confirmadas ao exame clínico. A SM foi diagnosticada usando os critérios do Adult Treatment Panel III (NCEP-ATPIII), revistos e atualizados pela American Heart Association (AHA/NHLBI). A prevalência observada de LAHIV foi de 55%. Os pacientes com LAHIV apresentaram maior duração da infecção por HIV, da aids e do uso de anti-retrovirais. Na análise multivariada, estiveram independentemente associados ao risco de LAHIV: sexo feminino (p = 0,006) e duração da aids 8 anos (p < 0,001). Quanto aos critérios para SM, hipertensão foi detectada em 32%, baixo HDL-colesterol em 68%, hipertrigliceridemia em 55%, cintura aumentada em 17% e glicemia aumentada e/ou diabetes em 23% dos indivíduos. A cintura aumentada e a hipertrigliceridemia foram mais comuns em portadores de LAHIV. A SM foi identificada em 36% dos pacientes. Na análise multivariada, estiveram associados à SM: IMC 25 kg/m 2 (p < 0,001), história familiar de obesidade (p = 0,01), uso de indinavir (p = 0,001) e idade 40 anos no diagnóstico do HIV (p = 0,002). A LAHIV apresentou tendência a ser mais comum em portadores de SM (65% versus 50%, p = 0,051). A prevalência de LAHIV que se observou neste grupo (55%) foi similar à descrita em estudos prévios de outros países. A prevalência de SM nestes pacientes parece ser diferente da descrita em adultos brasileiros não-infectados pelo HIV. (Arq Bras Endocrinol Metab 2008; 52/4:658-667) Descritores: Síndrome da lipodistrofia associada ao HIV; Síndrome X metabólica; Infecções por HIV; Prevalência; Brasil.

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“…Related to this, abdominal obesity as a typically morphological abnormality has been observed among both HIV-positive men and women (Galli et al, 2003;Jaime et al, 2006) in many countries where HAART has been available for a long time. Two recent studies showed that 45.7% (n= 223) of Brazilian HIV+ (Jaime et al, 2006) and 30.7% (n=471) of American HIV infected subjects (Mondy et al, 2007) had central obesity.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Abdominal Obesity among HIV-infected Adults on Antiretroviral Therapy in Malaysia

Hejazi¹,

Lee²,

Lin³

et al. 2010

GJHS

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Abdominal or central obesity is a common morphological alteration among HIV-infected subjects on antiretroviral treatment. There is concern that this condition places the subjects at risk of cardiovascular disease. This is a cross-sectional study of 334, HIV-infected adult subjects on antiretroviral therapy at a public hospital in Malaysia. It was aimed at determining the association between nutritional factors and abdominal obesity among PLHIV receiving antiretroviral treatment. Abdominal obesity was prevalent in 36.5% of the respondents. Respondents with abdominal obesity were significantly (p<0.05) older in age, had significantly higher blood triglycerides, fasting plasma glucose, lower HDL-cholesterol, higher BMI at the start of medication and also at the time of the study, bigger waist circumference, higher waist hip ratio, body fat mass, systolic and diastolic blood pressure. They also had lower mean CD4 cell count at start of medication and body lean mass than those without abdominal obesity. After adjusting for the covariates, a significantly higher risk of abdominal obesity was observed in those who were older (adjusted OR=1.053, CI=1.012-1.095), had higher fasting plasma glucose (adjusted OR=1.189, CI=1.014-1.394), higher BMI at the time of study (adjusted OR=1.426,. Being Malay was a protective factor (adjusted OR=0.264, CI=00.102-0.685) for abdominal obesity. These results suggest that care of the HIV-infected population must include intervention to address abdominal obesity in order to provide better quality of life.

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Metabolic Syndrome in HIV-Infected Patients from an Urban, Midwestern US Outpatient Population

Abstract: The prevalence of metabolic syndrome is high among HIV-infected persons, but not higher than the prevalence among HIV-uninfected persons. Traditional risk factors play a more significant role in the development of metabolic syndrome than do HIV treatment-associated factors.

Cited by 181 publications

References 30 publications

Pattern of dyslipidaemia in human immunodeficiency virus infected patients- a study from rural tertiary care hospital in central India

Pattern of dyslipidaemia in human immunodeficiency virus infected patients- a study from rural tertiary care hospital in central India

Prevalência da lipodistrofia associada ao HIV em pacientes ambulatoriais brasileiros: relação com síndrome metabólica e fatores de risco cardiovascular

Factors Associated with Abdominal Obesity among HIV-infected Adults on Antiretroviral Therapy in Malaysia

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