Metabolic syndrome in fifth grade children with acanthosis nigricans: results from the CARDIAC project

Ice, Christa; Murphy, Emily; Minor, Valerie; Neal, William A.

doi:10.1007/s12519-009-0004-7

Cited by 35 publications

(37 citation statements)

References 41 publications

(52 reference statements)

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“…Different points of measurement were detected and cut-offs points have varied: $85th percentile of the population studied (47) and $90th percentile for age and sex (42,43) . In the present study, two measurement sites were accurate in predicting (6) reported that WC3 correlated significantly with all components of MetS in children aged 6-13 years.…”

Section: Discussionmentioning

confidence: 99%

Anthropometry and physical activity level in the prediction of metabolic syndrome in children

Andaki

Tinôco

Mendes

et al. 2013

Public Health Nutr.

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Objective: To evaluate the effectiveness of anthropometric measures and physical activity level in the prediction of metabolic syndrome (MetS) in children. Design: Cross-sectional study with children from public and private schools. Children underwent an anthropometric assessment, blood pressure measurement and biochemical evaluation of serum for determination of TAG, HDL-cholesterol and glucose. Physical activity level was calculated and number of steps per day obtained using a pedometer for seven consecutive days. Setting: Viçosa, south-eastern Brazil. Subjects: Boys and girls (n 187), mean age 9?90 (SD 0?7) years. Results: Conicity index, sum of four skinfolds, physical activity level and number of steps per day were accurate in predicting MetS in boys. Anthropometric indicators were accurate in predicting MetS for girls, specifically BMI, waist circumference measured at the narrowest point and at the level of the umbilicus, four skinfold thickness measures evaluated separately, the sum of subscapular and triceps skinfold thickness, the sum of four skinfolds and body fat percentage. Conclusions: The sum of four skinfolds was the most accurate method in predicting MetS in both genders.

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Section: Discussionmentioning

confidence: 99%

Anthropometry and physical activity level in the prediction of metabolic syndrome in children

Andaki

Tinôco

Mendes

et al. 2013

Public Health Nutr.

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“…Over one-third of the current population was overweight and obese. As noted in another study by Ice et al [34], obesity-associated AN is a reliable and early marker for the metabolic syndrome in pediatric patients. High prevalence of overweight was found among the current study subjects.…”

Section: Discussionmentioning

confidence: 63%

“…Of the nine types of AN, obesity-associated AN is the most common type. Research indicates that the "associated skin legions are weight dependent and regresses with weight reduction" [34]. Exercise and improved diet can help to lower insulin levels and can improve AN which is expected to reduce the risk for T2D and CVD.…”

Section: Introductionmentioning

confidence: 99%

“…Exercise and improved diet can help to lower insulin levels and can improve AN which is expected to reduce the risk for T2D and CVD. In one study Ice et al [34] found that AN is an early marker for the metabolic syndrome among pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, examining adolescents for the presence of AN; a marker of IR and a marker for pediatric diabetes [34] can be performed prior to later symptoms and can be easily accomplished within the schools. The Center for Disease Control (CDC) in the United States of America recommend early screening for children over 10 years who present with any clinical signs of METS (central obesity, raised blood pressure, raised triglycerides, low HDL-C, and fasting hyperglycemia), family history of T2D, are of particular ethnic origins (Asians, Hispanics, Indians and African Americans), and if they are extremely obese with BMI of > 30 kg/m 2 and fall in the >95 th percentile [1,35].…”

Section: Introductionmentioning

confidence: 99%

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Acanthosis Nigricans: relation to risk of Type 2 diabetes and cardiovascular diseases among Jamaican adolescents

Barrett¹,

Huffman²,

Johnson³

et al. 2016

Integr Food Nutr Metab

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adulthood [8,14]. Obesity has been cited as "a risk factor for CVD, ventricular dysfunction, congestive heart failure, stroke, and cardiac arrhythmias" [15]. According to Calderon et al. [16] "Persons with body mass index (BMI) >35 kg/m 2 are 2-3 times more likely than lean persons with lower BMI (18.5-24.9 kg/m 2 ) to die from CVD". Therefore, detection of the early signs of T2D and CVD is needed to help in the prevention of these and other related medical conditions. Similar to higher BMI, abdominal fat or central adiposity is closely associated with hyperinsulinemia and IR [17]. According to Ramachandran (2004) AbstractThe objectives of the study were to determine if Jamaican adolescents were at risk for type 2 diabetes (T2D) and cardiovascular diseases (CVD), and examine the relationship between the presence of Acanthosis Nigricans (AN) and the risk of developing T2D and CVD among Jamaican adolescents.A descriptive epidemiological cross-sectional study of 276 Jamaican adolescents ages 14-19 years (15.6 ± 1.2) participated. Subjects were selected from grades 9-12 from ten high schools on the island and included males (112) and females (164). Fasting blood glucose (FBG), total cholesterol (TC), glycated hemoglobin (A1c), blood pressure (BP), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and presence of Acanthosis Nigricans were examined. Of the eight risk factors for T2D and CVD examined, the presence of AN classified more subjects at risk than all the other risk factors. Spearman correlations of AN with the other seven risk factors were highly significant for six of these other risk factors (P<0.05). High A1c was the only risk factor which did not correlate with the presence of AN (P=0.085). Females had significantly higher WC (P<0.041), and presence of AN (P<0.013), whereas, males had significantly higher FBG (P<0.039). Urban subjects had significantly higher BMI (P<0.018) and WC (P<0.021) than rural subjects. High total cholesterol was significant for subjects with lower income (P<0.039). The presence of AN classified more subjects at risk than did the other seven risk factors. Examining students for the presence of AN can be economically and easily performed within the schools. A1c classified more subjects at risk for T2D and CVD than FBG and TC, however, there was no correlation between high A1c and the presence of AN. Over one third of the study subjects reported three or more risk factors for T2D and CVD which indicates early intervention measures are needed for this population.

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Dermatologic Disorders in Children of Color

Silverberg

2012

Skin of Color

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Metabolic syndrome in fifth grade children with acanthosis nigricans: results from the CARDIAC project

Cited by 35 publications

References 41 publications

Anthropometry and physical activity level in the prediction of metabolic syndrome in children

Anthropometry and physical activity level in the prediction of metabolic syndrome in children

Acanthosis Nigricans: relation to risk of Type 2 diabetes and cardiovascular diseases among Jamaican adolescents

Dermatologic Disorders in Children of Color

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