Metabolic Syndrome in Early Pregnancy and Risk of Preterm Birth

Chatzi, Leda; Plana, Estel; Daraki, Vasiliki; Karakosta, Polyxeni; Alegkakis, D.; Tsatsanis, Christos; Kafatos, A.; Koutis, Antonis; Kogevinas, Manolis

doi:10.1093/aje/kwp211

Cited by 171 publications

(179 citation statements)

References 31 publications

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“…This incidence of preterm deliveries is supported by study done by Chatzi et al, where they found a strong association between development of metabolic syndrome and subsequent preterm delivery. 14 In the present study, 72 (72%) patients had normal delivery, 04 (04%) patients had instrumental delivery and 24 (24%) had caesarean delivery. In glibenclamide group 34 (68%) patients had normal delivery, 04 (08%) patients had instrumental delivery and 12 (24%) patients had caesarean delivery, whereas in insulin group 38 (76%) patients had normal delivery and 12 (24%) patients had caesarean delivery.…”

Section: Discussionsupporting

confidence: 42%

A comparative study of using glibenclamide versus insulin in the treatment of gestational diabetes mellitus and its outcome

Rao

Datta

Prajwal

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Gestational diabetes mellitus(GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. This study aims at determining the efficacy of the glibenclamide versus insulin in achieving the adequate glycemic control and to analyze the maternal and fetal outcomes and to determine the failure rate of glibenclamide, patient compliance and overall cost of the treatmentMethods: This study was carried out for a period of 22 months at Command Hospital Air Force, Bangalore in Dept. of OBG. Women with GDM whose glycemic control was not achieved with medical nutrition therapy with fasting blood sugar (FBS) values >105mg/dl and 2hour post prandial blood sugar (PP) value >140mg/dl were selected and randomized for treatment either glibenclamide or insulin (50 in each group).Results: The age of the patients in this study ranged from 23 to 33 years. The mean age in glibenclamide group was 27.32 (SD ± 2.84) where as in insulin group was 26.30 (SD ± 3.01). The mean plasma glucose level achieved with glibenclamide was fasting -87.62 mg/dl, post prandial -116.44 mg/dl, before lunch - 95.62mg/dl, after lunch -115.80 mg/dl, before dinner-91.96 mg/dl, after dinner - 116.64 mg/dl, 3AM - 84.42 mg/dl and next day fasting - 86.30mg/dl in comparison with insulin where fasting- 85.54 mg/dl , post prandial -114.14 mg/dl, before lunch - 87.08, after lunch -112.82 mg/dl, before dinner-86.76 mg/dl and after dinner - 114.18 mg/dl, 3AM - 81.16 mg/dl and next day fasting was 86.72mg/dl which is statistically significant. The incidence of maternal and neonatal morbidities was comparable in both the group. 4 % percent of patient treated with glibenclamide had treatment failure. The cost of the treatment and compliance was better with glibenclamide.Conclusions: It has been concluded that glibenclamide is effective as insulin in achieving adequate glycemic control with no significant maternal and fetal morbidity and mortality.

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Section: Discussionsupporting

confidence: 42%

A comparative study of using glibenclamide versus insulin in the treatment of gestational diabetes mellitus and its outcome

Rao

Datta

Prajwal

2017

Int J Reprod Contracept Obstet Gynecol

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“…* Totals may not add up to 75 because of missing values.† Represents a test for linear trend with the exception of sex, smoking habits and breastfeeding duration (Wald test).‡ According to the IOM 2009 gestational weight gain guidelines 12.§ Based on internally standardized percentile values as previously described 4.¶ According to the World Health Organization growth reference 6, 7, 8. For both BMI and height, the ‘<1 z‐score’ category includes one child with z‐score <−2.…”

Section: Resultsmentioning

confidence: 99%

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother–child cohort in Crete, Greece

Perng

Oken

Roumeliotaki

et al. 2016

Obesity Science & Practice

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SummaryObjectiveThis study aims to investigate relations of serum leptin at age 4 with development of adiposity and linear growth during 3 years of follow‐up among 75 Greek children and to identify serum metabolites associated with leptin at age 4 and to characterize their associations with adiposity gain and linear growth.MethodsLinear regression models that accounted for maternal age, education and gestational weight gain and child's age and sex were used to examine associations of leptin and leptin‐associated metabolites measured at age 4 with indicators of adiposity and linear growth at age 7.ResultsEach 1‐unit increment in natural log‐(ln)‐transformed leptin corresponded with 0.33 (95% CI: 0.10, 0.55) units greater body mass index‐for‐age z‐score gain during follow‐up. Likewise, higher levels of the leptin‐associated metabolites methylmalonyl‐carnitine and glutaconyl‐carnitine corresponded with 0.14 (95% CI: 0.01, 0.27) and 0.07 (95% CI: −0.01, 0.16) units higher body mass index‐for‐age z‐score gain, respectively. These relationships did not differ by sex or baseline weight status and were independent of linear growth.ConclusionsThese findings suggest that leptin, methylmalonyl‐carnitine and possibly glutaconyl‐carnitine are associated with weight gain during early childhood. Future studies are warranted to confirm these findings in other populations.

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“…Detailed characteristics of the study population have been described elsewhere (16) . A random sample of 828 mothers were contacted by telephone at the 18 months follow-up and 599 (72 %) agreed to participate in the neurodevelopmental assessment (17) .…”

Section: Study Populationmentioning

confidence: 99%

Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother–child cohort ‘Rhea’ study in Crete, Greece

Chatzi

Papadopoulou

Koutra

et al. 2012

Public Health Nutr.

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Objective: To investigate whether high doses of folic acid supplementation in early pregnancy are associated with child neurodevelopment at 18 months of age. Design: The study uses data from the prospective mother-child cohort 'Rhea' study. Pregnant women completed an interviewer-administered questionnaire on folic acid supplementation at 14-18 weeks of gestation. Neurodevelopment at 18 months was assessed with the use of the Bayley Scales of Infant and Toddler Development (3rd edition). Red-blood-cell folate concentrations in cord blood were measured in a sub-sample of the study population (n 58). Setting: Heraklion, Crete, Greece, 2007Greece, -2010. Subjects: Five hundred and fifty-three mother-child pairs participating in the 'Rhea' cohort. Results: Sixty-eight per cent of the study participants reported high doses of supplemental folic acid use (5 mg/d), while 24 % reported excessive doses of folic acid (.5 mg/d) in early pregnancy. Compared with non-users, daily intake of 5 mg supplemental folic acid was associated with a 5-unit increase on the scale of receptive communication and a 3?5-unit increase on the scale of expressive communication. Doses of folic acid supplementation higher than 5 mg/d were not associated with additional increase in the neurodevelopmental scales. Conclusions: This is the first prospective study showing that high doses of supplementary folic acid in early pregnancy may be associated with enhanced vocabulary development, communicational skills and verbal comprehension at 18 months of age. Additional longitudinal studies and trials are needed to confirm these results.

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Metabolic Syndrome in Early Pregnancy and Risk of Preterm Birth

Cited by 171 publications

References 31 publications

A comparative study of using glibenclamide versus insulin in the treatment of gestational diabetes mellitus and its outcome

A comparative study of using glibenclamide versus insulin in the treatment of gestational diabetes mellitus and its outcome

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother–child cohort in Crete, Greece

Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother–child cohort ‘Rhea’ study in Crete, Greece

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