Metabolic Syndrome in Children and Adolescents

Wittcopp, Chrystal; Conroy, Rushika

doi:10.1542/pir.2014-0095

Cited by 86 publications

(89 citation statements)

References 44 publications

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“…Close to 90% of obese children and adolescents have at least one feature of the metabolic syndrome (18). The prevalence is also higher in Hispanics compared to Caucasian, or African American population (14,24). A clustering of risk factors associated with metabolic syndrome has been demonstrated in certain adult populations, including East Asians, Asian Indians, Native Americans, Japanese Americans and Hispanics (25,26).…”

Section: Epidemiologymentioning

confidence: 99%

“…Due to varying definitions, and an attempt to achieve some consensus, a statement was made by the Joint Task Force. According to this statement, the proposed criteria for metabolic syndrome in adults should include 3 of the following 5 criteria (14,15):…”

Section: Definitionmentioning

confidence: 99%

“…Though the definitions have many similarities, there are important differences between them with respect to cut-off points for various parameters. These are summarized in Tables 1 and 2 (13,14,(18)(19)(20)(21).…”

Section: Definitionmentioning

confidence: 99%

“…Although the pathogenesis of metabolic syndrome is not completely understood, recent data suggest that interaction between obesity, insulin resistance and inflammation play a key-role in its development (14). It is suggested that accumulation of free fatty acids in the liver, adipocytes, skeletal muscles and the pancreas in the setting of obesity leads to impaired insulin signaling and subsequent insulin resistance.…”

Section: Pathogenesismentioning

confidence: 99%

“…The increase in free fatty acids delivery to the liver is thought to result in hepatic insensitivity to the inhibitory effects of insulin on very low density lipoprotein (VLDL) secretion and overproduction of triglyceride-rich VLDL particles (28). Elevated BP in metabolic syndrome is thought to be secondary to hyperinsulinemia via mechanisms such as sympathetic nervous system activity, renal sodium retention and smooth muscle growth (14). Insulin has a vasodilatory effect on the endothelium secondary to the production of nitric oxide (a potent vasodilator) (29).…”

Section: Pathogenesismentioning

confidence: 99%

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Metabolic syndrome in children and adolescents

2017

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Prevalence of metabolic syndrome in children and adolescents is increasing, in parallel with the increasing trends in obesity rates. Varying definitions of this syndrome have hindered the development of a consensus for the diagnostic criteria in the pediatric population. While pathogenesis of metabolic syndrome is not completely understood, insulin resistance and subsequent inflammation are thought to be among its main mechanistic underpinnings. Overweight and obesity are cardinal features, along with abnormal glucose metabolism, dyslipidemia, and hypertension. Other disorders associated with metabolic syndrome include fatty liver, polycystic ovarian syndrome (PCOS), and pro-inflammatory states. Prevention and management of this condition can be accomplished with lifestyle modifications, behavioral interventions, pharmacological and surgical interventions as needed.

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Section: Epidemiologymentioning

confidence: 99%

Section: Definitionmentioning

confidence: 99%

Section: Definitionmentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

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Metabolic syndrome in children and adolescents

2017

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Healthy beverage index could decrease odds of metabolic syndrome: A cross‐sectional study

Nouri

Shateri

Rezaei

et al. 2023

Food Science & Nutrition

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Some studies indicated that sugar‐sweetened beverages (SSBs) were related to MetS risk, and others found no relationship between MetS and SSBs. Therefore, the present study aimed to investigate the relationship between healthy beverage index (HBI) and MetS in Iranian adults. This cross‐sectional study was performed on baseline data FASA cohort. Out of 10,127 participants in the FASA cohort study, 8838 participants were included in this study. The National Cholesterol Education Program's Adult Treatment Panel (ATP) III was used for MetS definition. The HBI was calculated by a 125‐item food frequency questionnaire with standard criteria. The association between HBI and MetS and its components was evaluated by univariate regression. Multivariate regression with the backward method was used for adjusting confounders. p < .05 was considered as statistically significant. Compared to the first quartile, it was observed that HBI in the last quartile was significantly related to lower odds of MetS in the multivariate analysis (odds ratio [OR] = 0.72; 95% confidence interval [CI]: 0.60–0.87, p < .001). Also, we observed a significant association between the last quartile of HBI with lower odds of high waist circumference (WC) (OR = 0.55; 95% CI: 0.45–0.67, p < .002). Our findings showed that the higher HBI score reduced MetS odds and WC. Therefore, to reduce the odds of MetS, a healthy pattern of beverage consumption, including drinking water, low‐fat milk, unsweetened tea, and coffee, and reducing the consumption of SSB are recommended. More studies are needed to confirm the findings.

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Genetic variations in IKZF3, LET7‐a2, and CDKN2B‐AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations

Paniri,

Hosseini,

Fattahi

et al. 2024

Clinical Laboratory Analysis

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Background and aimMetabolic syndrome (MetS) increases the risk of atherosclerosis and diabetes, but there are no approved predictive markers. This study assessed the role of specific genetic variations in MetS susceptibility and their impact on clinical manifestations.MethodIn this study, a genotype–phenotype assessment was performed for IKZF3 (rs907091), microRNA‐let‐7a‐2 (rs1143770), and lncRNA‐CDKN2B‐AS1 (rs1333045).ResultsAnalyses indicate that while rs907091 and rs1143770 may have potential associations with MetS susceptibility and an increased risk of atherosclerosis and diabetes, there is an observed trend suggesting that the rs1333045 CC genotype may be associated with a decreased risk of MetS. The genotypes and allele frequencies of rs1333045 were significantly different between studied groups (OR = 0.56, 95% CI 0.38–0.81, p = 0.002, and OR = 0.71, 95% CI 0.55–0.92, p = 0.008), with the CC genotype displaying increased levels of HDL. Furthermore, the rs907091 TT genotype was associated with increased triglyceride, cholesterol, and HOMA index in MetS patients. Subjects with the CC genotype for rs1143770 had higher HbA1c and BMI. In silico analyses illustrated that rs907091 C remarkably influences the secondary structure and the target site of a broad spectrum of microRNAs, especially hsa‐miR‐4497. Moreover, rs1333045 creates a binding site for seven different microRNAs.ConclusionFurther studies on other populations may help confirm these SNPs as useful predictive markers in assessing the MetS risk.

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Metabolic Syndrome in Children and Adolescents

Cited by 86 publications

References 44 publications

Metabolic syndrome in children and adolescents

Metabolic syndrome in children and adolescents

Healthy beverage index could decrease odds of metabolic syndrome: A cross‐sectional study

Genetic variations in IKZF3, LET7‐a2, and CDKN2B‐AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations

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