Metabolic syndrome does not increase the risk of conversion of impaired glucose tolerance to diabetes in Asian Indians—Result of Indian diabetes prevention programme

Ramachandran, Ambady; Snehalatha, Chamukuttan; Kumpatla, Satyavani; Sivasankari, S.; Vijay, V.

doi:10.1016/j.diabres.2006.08.009

Cited by 22 publications

(20 citation statements)

References 16 publications

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“…Metabolic syndrome is common in this population (23,24). However, we noted that it was not a determinant of conver- sion rate of IGT to diabetes in this population (25). The most unexpected findings in the study were the marked increase in prevalence of diabetes in the PUVs and a sharp reduction in IGT in all areas.…”

Section: Resultsmentioning

confidence: 41%

High Prevalence of Diabetes and Cardiovascular Risk Factors Associated With Urbanization in India

et al. 2008

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OBJECTIVE -To compare prevalence of diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and cardiovascular risk factors between a city, a town, and periurban villages (PUVs) in southern India and to look for temporal changes in the city and PUVs.RESEARCH DESIGN AND METHODS -Subjects aged Ն20 years were studied in Tamilnadu, India, in Chennai (city, n ϭ 2,192; 1,053 men and 1,138 women), Kanchipuram (town, n ϭ 2,290; 988 men and 1,302 women), and Panruti (PUVs, n ϭ 2,584; 1,280 men and 1,304 women) in 2006. Demographic, socioeconomic, and anthropometric details; blood pressure; physical activity; diet habits; and lipids were studied. Risk associations with diabetes were analyzed using multiple logistic regression analyses. Present and previous data in the city and the PUVs were compared.RESULTS -Mean BMI, waist circumference, and family history of diabetes were significantly lower in the PUVs. The PUVs had a lower prevalence of diabetes (9.2 [95% CI 8.0 -10.5], P Ͻ 0.0001) than the city (18.6 [16.6 -20.5]) and town (16.4 [14.1-18.6]). Approximately 40% of subjects were newly diagnosed. Prevalence of impaired glucose tolerance (IGT) was higher (P Ͻ 0.0001) in the city (7.4 [6.2-8.5]) than in the town (4.3 [3.3-5.3]) and the PUVs (5.5 [4.6 -6.5]). Prevalence of IFG was generally low. Age, family history, and waist circumference were significantly associated with diabetes, while physical activity was not. Overweight, elevated waist circumference, hypertension, and dyslipidemia were more prevalent in the city.CONCLUSIONS -In the city, diabetes increased from 13.9 to 18.6% in 6 years and IGT decreased significantly. The town and city had similar prevalences; the PUVs had lower diabetes prevalence, but prevalence had increased compared with that in a previous survey. Cardiometabolic abnormalities were more prevalent in urban populations.

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Section: Resultsmentioning

confidence: 41%

High Prevalence of Diabetes and Cardiovascular Risk Factors Associated With Urbanization in India

et al. 2008

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“…173 also determined the prevalence of the metabolic syndrome, as defined by the WHO criteria, in their trial participants. 227 It was found in 46% (95% CI 42% to 52%) overall, but was commoner in women (62%; 95% CI 52% to 71%) than men (42%; 95% CI 37% to 47%). The presence of metabolic syndrome did not increase the incidence of diabetes.…”

Section: Results: Primary Outcomesmentioning

confidence: 99%

“…173,[226][227][228] Participants were recruited by screening a middle-class population (n = 10,839) working in service organisations and their families, who were identified by workplace announcements and circulars. Those with IGT (according to WHO 1999 criteria) on two separate OGTTs were recruited.…”

Section: The Indian Diabetes Prevention Programmementioning

confidence: 99%

Non-pharmacological interventions to reduce the risk of diabetes in people with impaired glucose regulation: a systematic review and economic evaluation.

Gillett

Royle²,

Snaith³

et al. 2012

Health Technol Assess

111

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projec...

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“…The Metabolic syndrome as first defined by Reaven (1988) is a cluster of insulin resistance with hypertension, dyslipidemia and obesity. MS is a significant risk factor for development of CVD and is found to be highly prevalent in the Asian Indian population (Misra and Vikram 2002; Shah et al 2005; Chow et al 2007; Deepa et al 2007; Ramachandran et al 2007). In our study we have designated MS to the participants using the NCEP–ATPIII guidelines (1998) and find significantly larger number of people with MS in the CVD high risk group.…”

Section: Discussionmentioning

confidence: 99%

Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians

Kanjilal

Rao²,

Mukherjee³

et al. 2008

Vasc Health Risk Manag

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Abstract:The increasing pressure on health resources has led to the emergence of risk assessment as an essential tool in the management of cardiovascular disease (CVD). Concern exists regarding the validity of their generalization to all populations. Existing risk scoring models do not incorporate emerging 'novel' risk factors. In this context, the aim of the study was to examine the relevance of British, European, and Framingham predictive CVD risk scores to the asymptomatic high risk Indian population. Blood samples drawn from the participants were analyzed for various 'traditional' and 'novel' biomarkers, and their CVD risk factor profi ling was also done. The Framingham model defi ned only 5% of the study cohort to be at high risk, which appears to be an underestimation of CVD risk in this genetically predisposed population. These subjects at high risk had signifi cantly elevated levels of lipid, pro-infl ammatory, pro-thrombotic, and serological markers. It is more relevant to develop risk predictive scores for application to the Indian population. This study substantiates the argument that alternative approaches to risk stratifi cation are required in order to make them more adaptable and applicable to different populations with varying risk factor and disease patterns.

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Metabolic syndrome does not increase the risk of conversion of impaired glucose tolerance to diabetes in Asian Indians—Result of Indian diabetes prevention programme

Cited by 22 publications

References 16 publications

High Prevalence of Diabetes and Cardiovascular Risk Factors Associated With Urbanization in India

High Prevalence of Diabetes and Cardiovascular Risk Factors Associated With Urbanization in India

Non-pharmacological interventions to reduce the risk of diabetes in people with impaired glucose regulation: a systematic review and economic evaluation.

Application of cardiovascular disease risk prediction models and the relevance of novel biomarkers to risk stratification in Asian Indians

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