Metabolic Syndrome Development in Relation to Low Birth Weight

Abstract

The metabolic syndromes are constellation of major risk factor for high fasting tri-aceylglycerols, obesity, low level of HDL cholesterol, higher fasting plasma insulin, hypertension and impaired glucose tolerance. A rat model of maternal diet was used to observe this relationship. This study investigated the metabolic syndrome development in relation to low birth weight. In this study 4 pairs of rats was used and was divided into 2 groups each consisting of 2 pairs as G1 normal and G2 was taken from animal lab of national institute of food science and technology. Control group was fed standard diet. Experimental group was fed 50% low diet as compared to control group during child bearing and lactation period. Offspring of rats was introduced solid diet and then reviewed at 20 day and 40 day of age respectively. The mother body weight and feed intake was measured daily. The overall mean body weight of mothers was significantly increased in control and decreased in experimental group. The control dam's offspring body weight significantly higher than experimental dam's offspring till weaning, however low birth weight offspring of rats show catch-up growth after weaning or 20 days. Serum glucose, cholesterol level of low birth weight offspring of rat's was higher than normal weight offspring.