Metabolic syndrome decreases tissue perfusion and induces glandular hyperplasia in the fructose‐fed rat prostate

Abstract

Metabolic syndrome in the FR decreases prostatic perfusion and induces prostatic glandular hyperplasia. The findings suggest that chronic ischemia may be a link between metabolic syndrome and prostatic enlargement.

Metabolic Syndrome Enhances Prostate Contractility and In Vitro Phenylephrine‐induced α1‐Adrenoceptor Protein Expression in the Fructose‐fed Rat

“…A previous study demonstrated that the ventral prostate weight was significantly increased by 43% in the FR, while histology showed glandular hyperplasia. Moreover, the morphometric area and number of stromal cells were both increased in the prostatic stroma . The current study showed that in addition to the anatomical size increase, the FR prostate also exhibited heightened contractile responses to KCl and α ‐adrenergic stimulation, thus making the animal a suitable research model of metabolic syndrome‐induced BPH.…”

“…Moreover, the morphometric area and number of stromal cells were both increased in the prostatic stroma. 8 The current study showed that in addition to the anatomical size increase, the FR prostate also exhibited heightened contractile responses to KCl and α-adrenergic stimulation, thus making the animal a suitable research model of metabolic syndrome-induced BPH. Similar findings were reported by Vikram et al in rats kept on a high-fat diet.…”

“…Increased contractile response to KCl suggested that the contractile capacity of the prostate was enhanced in the FR. One possible explanation for the increased contractility was through increase in prostate stromal cells, which consist mainly of smooth muscle cells and myofibroblasts . In general, human myofibroblasts may have very heterogeneous origins; however, their development follows a well‐established sequence of events .…”

“…7 As for the prostate, glandular enlargement with hyperplastic changes in both acini and stroma were recently demonstrated in the FR. 8 The present study aimed to investigate the functional aspect of metabolic syndrome effect on the prostate by evaluating prostate α-adrenergic contractile function in FR.…”

Changes of urinary bladder contractility in high‐fat diet‐fed mice: The role of tumor necrosis factor‐α

“…In the fructose rat model, detrusor overactivity associated with bladder muscarinic receptor upregulation was shown at 6 weeks; detrusor underactivity and bladder nerve growth factor depletion at 9 weeks of high‐fructose diet feeding . Evidence of inflammatory changes was also reported in the fructose rat bladder and prostate . As TNF‐α is regarded as an important cytokine involved in systemic inflammation, the current study offers the novel finding of its role in linking obesity and the occurrence of bladder dysfunction.…”