Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats

Treviño, Samuel; Vázquez-Roque, Rubén Antonio; López-López, Gustavo; Pérez-Cruz, Claudia; Morán, Carolina; Handal-Silva, Anabella; González‐Vergara, Enrique; Flores, Gonzalo; Guevara, Jorge; Díaz, Alfonso

doi:10.1016/j.jchemneu.2017.02.007

Cited by 29 publications

(36 citation statements)

References 60 publications

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“…Recently, it has been demonstrated that the prevalence of chronic diseases including metabolic syndrome in menopausal women is increased [ 2 , 3 ]. Moreover, both menopausal condition and metabolic syndrome can induce memory impairment and decrease hippocampal plasticity [ 4 – 7 ]. Based on the rising trends of both menopause and metabolic syndrome mentioned earlier, the memory impairment in menopausal women with metabolic syndrome is increasing its importance and is recognized as one of the important health problems.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Kawvised

Thukham-mee

2017

Oxidative Medicine and Cellular Longevity

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Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50, and 250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks. Spatial memory together with neuron density, oxidative stress status, acetylcholinesterase, and phosphorylation of Erk in the hippocampus was assessed at the end of the study. It was found that MME decreased memory impairment, oxidative stress status, and AChE activity but increased neuron density and Erk phosphorylation in the hippocampus. Therefore, the neuroprotective and memory-enhancing effects of MME might partly involve the enhanced cholinergic function and Erk phosphorylation but decreased oxidative stress status in hippocampus. Therefore, MME is the potential novel neuroprotectant and memory-enhancing agent for menopause with metabolic syndrome. However, further research especially clinical trial is still necessary.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Kawvised

Thukham-mee

2017

Oxidative Medicine and Cellular Longevity

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“…In addition, the highest expression of proteins associated with memory such as SYP, involved in the vesicular release of neurotransmitters, is therefore proposed as a marker of synaptic function (Chen, Huang, Zhang, & Liu, ; Valtorta, Pennuto, Bonanomi, & Benfenati, ). However, the triggering of oxidative stress affects the functioning of glutamatergic receptors, reduces the expression of SYP, increases the number of reactive astrocytes, and activates processes of neurodegeneration that lead to the deficit of cognitive processes (Diaz et al, ; Singh & Joshi, ; Treviño et al, ).…”

Section: Discussionmentioning

confidence: 99%

The neuropeptide‐12 improves recognition memory and neuronal plasticity of the limbic system in old rats

Hernández-Hernández

Hernandez

Vázquez-Roque

et al. 2018

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Aging is a stage of life where cognitive and motor functions are impaired. This is because oxidative and inflammatory processes exacerbate neurodegeneration, which affects dendritic morphology and neuronal communication of limbic regions with memory loss. Recently, the use of trophic substances has been proposed to prevent neuronal deterioration. The neuropeptide-12 (N-PEP-12) has been evaluated in elderly patients with dementia, showing improvements in cognitive tasks due to acts as a neurotrophic factor. In the present work, we evaluated the effect of N-PEP-12 on motor activity and recognition memory, as well as its effects on dendritic morphology and the immunoreactivity of GFAP, Synaptophysin (SYP), and BDNF in neurons of the prefrontal cortex (PFC), dorsal hippocampus (DH) and nucleus accumbens (NAcc) of aged rats. The results show that N-PEP-12 improved the recognition memory, but the motor activity was not modified compared to the control animals. N-PEP-12 increases the density of dendritic spines and the total dendritic length in neurons of the PFC (layers 3 and 5) and in DH (CA1 and CA3). Interestingly NAcc neurons showed a reduction in the number of dendritic spines. In the N-PEP-12 animals, when evaluating the immunoreactivity for SYP and BDNF, there was an increase in the three brain regions, while the mark for GFAP decreased significantly. Our results suggest that N-PEP-12 promotes neuronal plasticity in the limbic system of aged animals, which contributes to improving recognition memory. In this sense, N-PEP-12 can be considered as a pharmacological alternative to prevent or delay brain aging and control senile dementias.

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“…This disorder is considered a precursor of DM type 2. In MS, alterations in the metabolism of carbohydrates and lipids during obesity are the main factors that cause insulin resistance and high levels of triglycerides and cholesterol (Alberti et al, 2009;Treviño et al, 2015Treviño et al, , 2017. A recent report from our group suggests (Treviño et al, 2015 that in rats, a 90-day high-caloric diet also causes deterioration in memory processes evaluated by the Novel Object Recognition Test and Morris Water…”

Section: Neur Al Tr Ans Miss I On In Animal Model Of Dmmentioning

confidence: 98%

“…In MS, alterations in the metabolism of carbohydrates and lipids during obesity are the main factors that cause insulin resistance and high levels of triglycerides and cholesterol (Alberti et al, ; Treviño et al, ). A recent report from our group suggests (Treviño et al, ) that in rats, a 90‐day high‐caloric diet also causes deterioration in memory processes evaluated by the Novel Object Recognition Test and Morris Water Maze with dendritic arbor retraction and a reduced number of dendritic spines in CA1, CA3, and the DG of the dorsal hippocampus. In addition, the amygdaloid complex is also affected by MS.…”

Section: Neural Transmission In Animal Model Of Dmmentioning

confidence: 99%

Consequences of diabetes mellitus on neuronal connectivity in limbic regions

Flores-Gómez

Gómez-Villalobos

Flores

2018

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Diabetes mellitus (DM) is characterized by high levels of blood glucose. In recent years, its prevalence has increased, which was 422 million in the world in 2014. In elderly patients, DM is associated with deficits in memory and learning processes. The cognitive deficits lead to dementia. With the development of animal models in DM, it has been possible to better understand quantitative morphological changes in numerous neuronal structures belonging to the limbic system, such as the prefrontal cortex (PFC), the hippocampus and basolateral amygdala (BLA). These structures are in close relationship with processes of memory and learning. Several reports have demonstrated that chronic hyperglycemia reduces spinogenesis and dendritic arborization in the aforementioned regions along with a decline in memory and learning processes, especially in streptozotocin (STZ)‐induced diabetic rats. In the present review, we discuss animal models, the effects of chronic hyperglycemia on dendritic morphology of limbic regions and memory and learning processes, the effect on neural transmission in these regions, the pathologic mechanisms involved, and the relevance of dendritic morphology in diabetes. All of this information can help us to have a better understanding of dementia in diabetes mellitus and propose strategies for its prevention and treatment.

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Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats

Cited by 29 publications

References 60 publications

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

Neuroprotective and Cognitive‐Enhancing Effects of Microencapsulation of Mulberry Fruit Extract in Animal Model of Menopausal Women with Metabolic Syndrome

The neuropeptide‐12 improves recognition memory and neuronal plasticity of the limbic system in old rats

Consequences of diabetes mellitus on neuronal connectivity in limbic regions

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