Metabolic Syndrome and Sexual Function in Postmenopausal Women

Trompeter, Susan E.; Bettencourt, Ricki; Barrett‐Connor, Elizabeth

doi:10.1016/j.amjmed.2016.03.039

Cited by 35 publications

(19 citation statements)

References 35 publications

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“…Principally women with systemic arterial hypertension presented a greater rate of FSD, evaluated by the Female Sexual Function Index questionnaire, versus nor-motensive women (90 and 41% respectively) and the use of antihypertensive medications was significantly related to lower prevalence of FSD [2,25,34,35,37]. …”

Section: Resultsmentioning

confidence: 99%

“…The number of participants ranged from 88 to 2,270 women. Only 9 studies looked specifically at MS [2,25,26,27,28,29,30,31,32]. The remaining included data about components of MS [2,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58].…”

Section: Resultsmentioning

confidence: 99%

“…Total 35 studies met the inclusion criteria (Table 1, 2) [2,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58]. Sixteen studies were classified as case-control studies [2,28,29,32,37,38,39,41,42,44,47,49,51,52,54,57] and the rest as observational/cross-sectional studies.…”

Section: Resultsmentioning

confidence: 99%

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The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review

et al. 2019

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Background: The impact of metabolic syndrome on female sexual dysfunction received modest consideration in clinical practice. The aim of the research was to analyze the international literature to determine the relationship between the metabolic syndrome, its components and female sexual disorders. Methods: We identified relevant full-length papers by electronic databases as Index Medicus/Medline, Scopus, Life Science Journals, from 2005 to the present. Studies were searched using the following as search query: metabolic syndrome, female sexual dysfunction, obesity, systemic arterial hypertension, diabetes mellitus, dyslipidemia. Results: Women with metabolic syndrome showed higher prevalence of sexual inactivity and low sexual desire, orgasm and satisfaction respect to women without metabolic syndrome. Particularly metabolic components as diabetes mellitus, dy-slipidemia, systemic arterial hypertension were strongly associated with lower sexual desire, activity and Female Sexual Function Index total score. In contrast, other studies showed no relationship. Conclusion: Our study showed that in the clinical evaluation of women with metabolic syndrome routine inquiring about female sexual dysfunction should be recommended to ameliorate sexual function and quality of life. However more prospective and longitudinal studies on the sexual effects of metabolic syndrome should also be suggested to know the factors related to women's sexuality better.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review

et al. 2019

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“…In our study, patients with sexual dysfunction had higher triglycerides values and poor glycemic control. Low sexual desire and arousal have been reported in menopausal patients with metabolic syndrome and poor lipid profile in previous studies (5,20,21). Several studies have also reported older age as a cause of sexual dysfunction in women (22,23).…”

Section: Discussionmentioning

confidence: 87%

Evaluation of factors affecting sexual dysfunction in female patients with diabetes mellitus

Yenice

Danacıoğlu

Mert

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: Our objective in this study was to evaluate the factors predicting female sexual dysfunction (FSD) in patients with diabetes mellitus (DM). Subjects and methods: The study included 149 women with DM. Sexual function was evaluated with the Female Sexual Function Index (FSFI) questionnaire, in which total scores under 26.55 characterized the occurrence of FSD (Group 1 > 26.55, Group 2 < 26.55). We recorded the patients' demographic, metabolic, and hormonal data. Ophthalmologic, neurologic, and renal complications were also evaluated. The antioxidant status of the patients in both groups was determined by measuring the activity of the enzymes paraoxonase-1 (PON-1) and arylesterase (ARE). Results: Based on the FSFI scores, 60 patients were allocated to Group 1 (26.6 ± 12.3) and 89 to Group 2 (22.6 ± 9.5). Group 2 compared with Group 1 had significantly (p < 0.05) higher mean concentrations of glycated hemoglobin (HbA1c), glucose, triglycerides, and insulin, along with higher rates of metformin use, smoking, retinopathy, and nephropathy. The mean serum ARE concentrations were significantly lower in Group 2 compared with Group 1 (p = 0.000), but the mean serum PON-1 concentrations were similar between both groups (p = 0.218). On multivariable regression analysis, age, ARE activity, Beck Depression Inventory (BDI) score, and menopause were significant independent predictors of FSD (p < 0.05). Conclusions: In this study, we evaluated the predictive factors determining FSD caused by DM. Despite the significant results found in our study, future randomized controlled studies with a long follow-up and a larger number of patients are required to determine how DM affects FSD. Arch Endocrinol Metab. 2020;64(3):319-25

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“…El sín-drome metabólico se asocia con disminución de la actividad sexual, deseo y satisfacción. La enfermedad de la arteria coronaria parece ser más prevalente en mujeres con actividad sexual baja (32) .…”

Section: Fisiopatologíaunclassified

Síndrome metabólico en el climaterio

Peralta

2018

Rev peru ginecol obstet.

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El aumento de la expectativa de vida de las mujeres se ha traducido en incremento de la morbimortalidad en las mujeres mayores, siendo las enfermedades cardiovasculares una de las más prevalentes. Una de las principales causas de morbilidad es el síndrome metabólico. Es necesario orientar al médico y a sus pacientes sobre las consecuencias de esta patología. Son los varones quienes son más tratados, dejando de lado a las mujeres por la errada percepción de que tienen un riesgo cardiovascular bajo. La fisiopatología de la resistencia a la insulina abre un abanico de conocimientos relacionados al incremento de los triglicéridos en sangre y con el mayor aclaramiento del HDL-colesterol por parte del hígado. La obesidad abdominal y la hipertensión arterial completan los elementos de diagnóstico del síndrome metabólico, el cual se hace cuando existen tres de los cinco factores mencionados. Durante la transición menopáusica hay un rápido incremento en la severidad de este síndrome, lo que provoca un aumento del riesgo cardiovascular. En la obesidad hay un estado proinflamatorio inducido por la mayor producción de citoquinas inflamatorias como TNF-alfa, resistina, leptina, por el adipocito obeso, las cuales están vinculadas con la mayoría de las enfermedades crónicas y con el cáncer. En relación a la hipertensión arterial, hay muchas pacientes que desconocen que son portadoras de esta patología y no se hacen tratar, aumentando su riesgo cardiovascular. Por todo lo anterior, el médico ginecólogo debe de familiarizarse con esta patología y tener una actitud activa al respecto con relación a su diagnóstico y manejo.

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Metabolic Syndrome and Sexual Function in Postmenopausal Women

Cited by 35 publications

References 35 publications

The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review

The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review

Evaluation of factors affecting sexual dysfunction in female patients with diabetes mellitus

Síndrome metabólico en el climaterio

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