Metabolic Syndrome and Risk of Development of Atrial Fibrillation

Watanabe, Hiroshi; Tanabe, Naohito; Watanabe, Tôru; Darbar, Dawood; Roden, Dan M.; Sasaki, Shigeru; Aizawa, Yoshifusa

doi:10.1161/circulationaha.107.744466

Cited by 369 publications

(176 citation statements)

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“…Prior studies examining risk of atrial fibrillation in relation to diabetes or impaired glucose metabolism have yielded conflicting results. 3,9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Our results are similar to those reported by several prospective studies, 12,14,18 including the Framingham Heart Study, 14 all of which reported ORs in the range of 1.4 to 1.6. Other studies found an association between higher blood glucose and increased risk of atrial fibrillation.…”

Section: Discussionsupporting

confidence: 90%

“…Both findings are associated with heightened risk of atrial fibrillation, 3,7-9 a common and serious arrhythmia that confers significant risks for stroke and death. 10,11 Many epidemiologic studies have examined atrial fibrillation risk in relation to diabetes or elevated blood glucose, with conflicting results: ten studies observed an association, 3,9,[12][13][14][15][16][17][18][19] while nine did not. 11,[20][21][22][23][24][25][26][27] Often, prior studies examined many possible predictive factors and were not designed to evaluate the role of diabetes specifically.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes Mellitus, Glycemic Control, and Risk of Atrial Fibrillation

et al. 2010

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BACKGROUND: Diabetes may be an independent risk factor for atrial fibrillation. However, results from prior studies are in conflict, and no study has examined diabetes duration or glycemic control. OBJECTIVE: To examine the association of diabetes with risk of atrial fibrillation and to describe risk according to diabetes duration and glycemic control. DESIGN: A population-based case-control study. PARTICIPANTS: Within a large, integrated healthcare delivery system, we identified 1,410 people with newlyrecognized atrial fibrillation from ICD-9 codes and validated cases by review of medical records. 2,203 controls without atrial fibrillation were selected from enrollment lists, stratified on age, sex, hypertension, and calendar year. MAIN MEASURES: Information on atrial fibrillation, diabetes and other characteristics came from medical records. Diabetes was defined based on physician diagnoses recorded in the medical record, and pharmacologically treated diabetes was defined as receiving antihyperglycemic medications. Information about hemoglobin A1c levels came from computerized laboratory data. KEY RESULTS: Among people with atrial fibrillation, 252/1410 (17.9%) had pharmacologically treated diabetes compared to 311/2203 (14.1%) of controls. The adjusted OR for atrial fibrillation was 1.40 (95% CI 1.15-1.71) for people with treated diabetes compared to those without diabetes. Among those with treated diabetes, the risk of developing atrial fibrillation was 3% higher for each additional year of diabetes duration (95% CI 1-6%). Compared to people without diabetes, the adjusted OR for people with treated diabetes with average hemoglobin A1c ≤7 was 1.06 (95% CI 0.74-1.51); for A1c >7 but ≤8, 1.48 (1.09-2.01); for A1c >8 but ≤9, 1.46 (1.02-2.08); and for A1c >9, 1.96 (1.22-3.14). CONCLUSIONS: Diabetes was associated with higher risk of developing atrial fibrillation, and risk was higher with longer duration of treated diabetes and worse glycemic control. Future research should identify and test approaches to reduce the risk of atrial fibrillation in people with diabetes.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus, Glycemic Control, and Risk of Atrial Fibrillation

et al. 2010

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“…The population with AF will significantly increase in the future with the increasingly aging society 1. In addition to the well‐known risk factors, including hypertension, diabetes mellitus, cardiovascular disease, obesity, metabolic syndrome, and chronic kidney disease, lifestyle characteristics such as alcohol consumption are significantly linked to the incidence and/or prevalence of AF 2, 3, 4, 5. Although catheter ablation (CA) is standard therapy for patients with AF,6, 7, 8 the impact of alcohol consumption on the outcomes of CA has not been discussed.…”

Section: Introductionmentioning

confidence: 99%

Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Takigawa

Takahashi

Kuwahara

et al. 2016

JAHA

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BackgroundAlthough several studies have reported an association between atrial fibrillation (AF) and alcohol, the impact of alcohol consumption on the outcome after catheter ablation (CA) for AF has not been discussed. We aimed to elucidate the effect of alcohol consumption on the outcome of CA for paroxysmal AF.Methods and ResultsWe examined 1361 consecutive patients with paroxysmal AF (mean age, 61±11 years, 334 women) who underwent CA, including 623 (45.8%) patients who consumed alcohol. The clinical characteristics and outcomes of CA were compared between patients who did and did not consume alcohol. No significant differences were seen in the left atrial size, duration of AF history, and incidence of nonpulmonary vein foci between 2 groups (P=NS). Although the AF recurrence‐free rate after the initial CA was higher in patients who did not consume alcohol (261/623 [41.9%] versus 252/738 [34.1%]; mean follow‐up, 44.4±30.7 months; P=0.003), the outcome after the final CA was similar between 2 groups (patients who consumed alcohol: 111/628 [17.7%] versus patients who did not consume alcohol: 138/738 [18.7%]; mean follow‐up, 53.1±25.8 months; P=0.67). The frequency (hazard ratio 1.07 per 1 day/week increase, CI 1.00–1.15, P=0.04) of alcohol consumption was significantly associated with AF recurrence after CA.ConclusionsThe frequency of alcohol consumption may be associated with AF recurrence after the initial CA for paroxysmal AF, but it may not affect the outcome after the final CA.

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“…Aggrecan is one of the major components of cartilage and binds to hyaluronan (HA) and links proteins to form huge aggregates. These aggregates lead to a hydrated gel-like structure of cartilage and resistibility to compression and deformation in joints [9]. Currently, there has been vast research to study factors that promote cartilage repair.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemistry Evaluation of TGF-β1, SOX-9, Type II Collagen and Aggrecan in Cartilage Lesions Treated with Conditioned Medium of Umbilical Cord Mesencyhmal Stem Cells in Wistar Mice (Rattus novergicus)

Soetjahjo

Hidayat

Sujuti

et al. 2018

J.Trop.Life.Science

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Currently, umbilical cord mesenchymal stem cells have the potential to be used as treatment options for any cartilage lesion. This research aimed to evaluate the effects of conditioned medium from umbilical cord mesenchymal stem cells (UC-MSC) on damaged cartilage through the expression of proteins TGF-β1, SOX-9, type II collagen and aggrecan, which are known to be related to chondrogenesis. UC-MSC were isolated from 19-days-pregnant Wistar mice and were cultured using the standard procedure to obtain 80% confluence. Subsequently, the culture was confirmed through a microscopic examination that was driven to be an embryoid body to obtain a pre-condition medium. This research utilized 3-month-old male Wistar mice and was categorized into 6 groups (3 control and 3 treatment groups). Each animal had surgery performed to create a femur condyle cartilage defect. The treatment groups were administered a dose of stem cells at 1 mL/kg. Next, immunohistochemical (IHC) staining was performed to examine the expression of TGF-β1, SOX-9, type II collagen and aggrecan in the 2 nd , 3 rd , and 4 th month of evaluation. The results were analyzed statistically using ANOVA test. For each of the treatment groups, there was increased expression (p < 0.05) in all proteins TGF-β1, SOX-9, type II collagen and aggrecan when compared with control groups at the 2 nd , 3 rd , and 4 th month of evaluation. Pre-conditioned medium from UC-MSC potentially increases the expression of TGF-β1, SOX-9, type II collagen and aggrecan in the damaged cartilage of Wistar mice.

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Metabolic Syndrome and Risk of Development of Atrial Fibrillation

Cited by 369 publications

References 50 publications

Diabetes Mellitus, Glycemic Control, and Risk of Atrial Fibrillation

Diabetes Mellitus, Glycemic Control, and Risk of Atrial Fibrillation

Impact of Alcohol Consumption on the Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation

Immunohistochemistry Evaluation of TGF-β1, SOX-9, Type II Collagen and Aggrecan in Cartilage Lesions Treated with Conditioned Medium of Umbilical Cord Mesencyhmal Stem Cells in Wistar Mice (Rattus novergicus)

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