Metabolic Syndrome and Related Inflammation, Prevalence, and Predictive Value of C-Reactive Protein in South Asian Youths

Malik, Maria; Malik, Madeeha; Sukhera, Ahmed Bashir; Khalid, Muhammad; Waqas, Ahmed; Qayyum, Wahhaj; Butt, Arthur J.; Baig, Ammad A; Butt, Adeel A.; Malik, Furrukh S.

doi:10.1089/met.2021.0016

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Metabolic disturbances resulting from MetS can induce a state of chronic low‐grade inflammation, which is implicated in the development of various diseases, including cardiovascular disease, type 2 diabetes, and cancer 4,25 . Individuals with MetS tend to exhibit higher levels of inflammatory markers such as CRP 26 compared to those without MetS. This chronic low‐grade inflammation and the ensuing increase in inflammatory mediators may facilitate tumorigenesis and contribute to the development of various cancer types.…”

Section: Discussionmentioning

confidence: 99%

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The association of metabolic syndrome score trajectory patterns with risk of all cancer types

Deng,

Liu,

Liu

et al. 2024

Cancer

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BackgroundMetabolic syndrome (MetS) elevates cancer risk. However, a single MetS assessment does not fully reveal the long‐term association with cancer. Inflammation, alongside MetS, could synergistically expedite both the onset and advancement of cancer. This study aims to investigate MetS score trajectories and cancer risk in a large, prospective cohort study.MethodsThe authors prospectively examined the relationship between MetS score trajectory patterns and new‐onset cancer in 44,115 participants. Latent mixture modeling was used to identify the MetS score trajectories. Cox proportional hazards regression models were used to evaluate the association between MetS score trajectory patterns and the risk of overall and site‐specific cancers.ResultsFour MetS score trajectory patterns were identified: low‐stable (n = 4657), moderate‐low (n = 18,018), moderate‐high (n = 18,288), and elevated‐increasing (n = 3152). Compared to participants with a low‐stable trajectory pattern, the elevated‐increasing trajectory pattern was associated with an elevated risk of overall (hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.04–1.55), breast (HR, 2.11; 95% CI, 1.04–4.34), endometrial (HR, 3.33; 95% CI, 1.16–6.77), kidney (HR, 4.52; 95% CI, 1.17–10.48), colorectal (HR, 2.54; 95% CI, 1.27–5.09), and liver (HR, 1.61; 95% CI, 1.09–4.57) cancers. Among participants with chronic inflammation (C‐reactive protein levels ≥3 mg/L), the elevated‐increasing trajectory pattern was significantly associated with subsequent breast, endometrial, colorectal, and liver cancers.ConclusionsTrajectories of MetS scores are associated with the occurrence of cancers, especially breast, endometrial, kidney, colorectal, and liver cancers, emphasizing the importance of long‐term monitoring and evaluation of MetS.Plain Language Summary The association between long‐term elevated metabolic syndrome (MetS) scores and a heightened risk of various cancers is a pivotal finding of our study. Our research further indicates that individuals with MetS, particularly when coupled with chronic inflammation, are at an increased risk of cancer. We propose that sustained monitoring and management of MetS could be beneficial in reducing cancer risk.

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Section: Discussionmentioning

confidence: 99%

“…26 compared to those without MetS. This chronic low-grade inflammation and the ensuing increase in inflammatory mediators may facilitate tumorigenesis and contribute to the development of various cancer types.…”

mentioning

confidence: 99%

The association of metabolic syndrome score trajectory patterns with risk of all cancer types

Deng,

Liu,

Liu

et al. 2024

Cancer

View full text Add to dashboard Cite

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Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation

Huang

Wang

et al. 2023

Journal of Ethnopharmacology

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Prevalence and factors associated with metabolic syndrome in university students and academic staff in Bangladesh

Ali,

Samadder,

Shourove

et al. 2023

Sci Rep

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Metabolic syndrome (MetS) is a group of medical conditions that increase the risk of cardiovascular disease, stroke, and type 2 diabetes. While there are numerous studies on the prevalence of MetS in the general adult population worldwide, limited information exists regarding its prevalence among university students and academic staff. This study aimed to determine the prevalence of MetS and associated risk factors among Bangladesh university students and academic staff. For this cross-sectional study, 583 participants were randomly selected from university students (n = 281) and academic staff (n = 302) in Bangladesh. The participants' fasting blood samples were collected, and their serum lipid profile levels, fasting blood glucose, and other parameters were measured using standard methods. MetS was defined according to the NCEP-ATP III model guidelines. Additionally, a questionnaire was administered to the participants to gather information on socio-demographics, lifestyle risk behaviours, and personal medical history. Multivariate logistic regression models were used to determine the risk factors associated with MetS. Overall, the prevalence of MetS was 27.7% in students and 47.7% in staff. There was a significant difference (p < 0.01) in MetS prevalence between male students (34.8%) and female students (17.2%). In contrast, it was comparatively higher in female staff (52.3%) than in male staff (45.8%), although the difference was not statistically significant. The prevalence of MetS and its components increased with age in student and staff groups. The most common component of MetS was low levels of HDL-C, which affected 78% and 81.4% of the students and staff, respectively. Logistic regression modelling showed that increased age, BMI, hypertension, dyslipidemia, low physical activity, and smoking were significantly associated with MetS in students (at least p < 0.05 for all cases). On the other hand, increased age and BMI, hypertension, and dyslipidemia were significantly associated with MetS in academic staff (at least p < 0.05 for all cases). In conclusion, this study indicates a high prevalence of MetS in university students and staff in Bangladesh. Age, BMI, hypertension and dyslipidemia were independently associated with the risk of MetS in both groups. The findings emphasize the importance of interventions for students and staff in academic settings in Bangladesh. It is crucial to implement health promotion activities such as healthy diet and exercise programs more rigorously. Further research with more representative samples is needed to get more clear insights into MetS prevalence in this particular population subgroup for targeted interventions.

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Metabolic Syndrome and Related Inflammation, Prevalence, and Predictive Value of C-Reactive Protein in South Asian Youths

Cited by 6 publications

References 25 publications

The association of metabolic syndrome score trajectory patterns with risk of all cancer types

The association of metabolic syndrome score trajectory patterns with risk of all cancer types

Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation

Prevalence and factors associated with metabolic syndrome in university students and academic staff in Bangladesh

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