Metabolic Syndrome and Prediabetes

Prevalence of cardio-metabolic syndrome in Nigeria: a systematic review

“…10 Interestingly, epidemiological evidence suggests that the relationship between diabetes and CVD begins earlier in progression from prediabetes to diabetes. 59 This should rekindle attention on assessment of these cardiovascular risk factors, including consensus agreed definition of CMS for Sub-Saharan population, for early identification and intervention at the stage where the morbid conditions can be modified.…”

“…6 Following Reaven in 1988, several clinical definitions have been proposed: the World Health Organization definition (WHO), 7 the European Group for Study of Insulin Resistance, the National Cholesterol Education program e Third Adult Treatment Panel (NCEP ATP-III), 8 the American Association of Clinical Endocrinologists (AACE), the International Diabetes Federation (IDF), 9 and the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) definitions. 10 This has led to some confusion on the part of clinicians regarding how to identify patients with the syndrome. 1 In order to salvage the situation, IDF and AHA/NHLBI representatives held discussion to attempt to resolve the remaining differences between definitions of CMS, which led to the recent consensus on harmonizing the definition of CMS.…”

Effect of Telmisartan on Olanzapine Induced Metabolic Syndrome in Ovariectomized Female Sprague-Dawley Rats

“…It is also called as syndrome X, dysmetabolic syndrome, cardiometabolic syndrome, insulin resistance syndrome, Reaven's syndrome, the deadly quartet, GHO (glucose intolerance, hypertension, obesity) syndrome [2,3]. Metabolic syndrome is a rising clinical challenge and is classified as a disease entity by the Center for Disease Control (CDC) and has an international classification of disease code of 277.7 [4]. Metabolic syndrome is the one of the most common chronic diseases worldwide and the fourth or fifth leading cause of death in the developed world [5].…”

Can We Prevent or Delay Type 2 Diabetes?

“…The incidence of type 2 diabetes increases with the increasing number of risk factors, 5% with 0 risk factors to 50% when all 5 risk factors are present (p<0.001) (15).…”

“…They were randomized into diet-only, exercise only, diet plus exercise groups, and a control group, which were associated with a 31% (p 0.03), 46% (p 0.0005) and 42% (p 0.005) reduction in the risk of developing diabetes, respectively, when compared to the control group. Factor analysis showed that both insulin resistance and insulin secretion had a significant association with the development of diabetes, and lifestyle intervention was more effective in subjects with lower insulin resistance and higher insulin secretion (15,21,22). …”