Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Asrih, Mohamed; Jornayvaz, François R.

doi:10.1016/j.mce.2015.02.018

Cited by 259 publications

(195 citation statements)

References 157 publications

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“…Metabolic syndrome (Mets), a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia is often found among nurses. [19] The newest research conducted in Canada has shown that occupational psychological stress does not lead towards obesity, contrary to expectations. [20] Research has shown that individual factors, such as physical inactivity, strain at home, and consumption of psychotropic drugs influence obesity.…”

Section: Discussionmentioning

confidence: 96%

Thyroid gland disturbances in pediatric shift work nurses employed in clinical hospital centre

Lalić¹

2015

JHA

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The aim of this paper is an attempt to explore the cause of thyroid gland disturbances in female pediatric nurses employed in a Pediatric Intensive Care Unit in an Eastern European hospital. A group of twenty hospital nurses was studied of whom fourteen suffered from some type of thyroid gland disturbances and a group of twenty primary care nurses with only sporadic incidence of thyroid disturbances. Regarding hypothyroidism they differ statistically significantly, p = .0399, as to obesity p = .0017, comparing thyroiditis p = .0374, and by goiter p = .008. Pediatric hospital nurses' occupation requires contact with sick newborns and small children for 12-hour shifts. Thyroid gland disturbances are not fully explained, they vary from genetically origins, autoimmune processes, environmental stressors. Daily high level stress exposure of the mentioned hospital nurses can contribute to developing thyroid disturbances. Trained medical staff under the pressures of caring for this population may become sick. In such departments more nurses should be employed if shift work is performed under elevated stress. Signs of this stress might include inadequate nourishment causing obesity and cigarette smoking especially in night shifts. It is the task of Occupational Medicine to determine if stress exposure causes thyroid disturbances, especially in 12 hour shift workers, resulting in interventions to enhance preventive measures.

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Section: Discussionmentioning

confidence: 96%

Thyroid gland disturbances in pediatric shift work nurses employed in clinical hospital centre

Lalić¹

2015

JHA

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“…This in turn aggravates and maintains the insulin resistant state, constituting a vicious cycle. Importantly, evidence shows that most of the patients developing NAFLD present at least one of the MetS traits [5] . Pathological findings in NASH include macrovesicular steatosis, ballooning degeneration (with or without Mallory bodies), with lobular or portal inflammation, (with or without fibrosis) [6] .…”

Section: Nonalcoholic Steatohepatitis In Children: the Modern Day Pedmentioning

confidence: 99%

Nonalcoholic Steatohepatitis in Children: The Modern Day Pediatric Epidemic

El‐Shabrawi

Issa

2015

Journal of Gastroenterology and Hepatology Research

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“…Recently, in the pathogenesis of MS, nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), further consideration has been paid to the supposed organosilanes, proteins with both endocrine or/and paracrine actions [6]. These contain most identified adipokines (mostly created by adipose tissue), myokines (principally formed by skeletal muscles) and hepatokines (mainly made by the liver) [7].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome

et al. 2017

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G LUCOSE intolerance, insulin resistance, hypertension, visceral obesity, and dyslipidemia are the major components of metabolic syndrome (MS). To evaluate the association between serum SHBG and IGF-1 levels and the risk of MS, Furthermore, to determine the correlations between SHBG and IGF-1 and the main components of MS. A total of 402 subjects with and without MS were enrolled in this study (MS=156, Non-MS=246) aged > 18 years. The age, height, weight, BMI, HC, WC, and incidence of diabetes, hypertension and dyslipidemia of all cases were recorded. The collected serum samples were used to assess lipid profile, glucose and insulin levels. The levels of LDL-cholesterol were calculated using Friedewald's formula. Insulin resistance was measured (as HOMA score). The levels of serum SHBG and IGF-1 were measured using Elisa technique. A positive relationship between SHBG and MS was detected, however no such correlation was observed concerning IGF-1. There were positive correlations between SHBG and main components of MS; with insulin, HOMA-index, TC, TG and HDL. Conversely, IGF-1 showed negative correlations. Finally, SHGB was more sensitive (63.5%), accurate (61.9%) than IGF-1 (51.9%), accuracy (59%). Our study reveals that lower SHBG is more strongly associated with metabolic syndrome and its main components that lower IGF-1. SHBG could be the essential driver of these relations, conceivably reflecting its association with insulin sensitivity; however more studies are required to confirm this relationship.

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Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Cited by 259 publications

References 157 publications

Thyroid gland disturbances in pediatric shift work nurses employed in clinical hospital centre

Thyroid gland disturbances in pediatric shift work nurses employed in clinical hospital centre

Nonalcoholic Steatohepatitis in Children: The Modern Day Pediatric Epidemic

Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome

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