Metabolic Syndrome and Menopause

Stefańska, Anna; Bergmann, Katarzyna; Sypniewska, Grażyna

doi:10.1016/bs.acc.2015.07.001

Cited by 172 publications

(77 citation statements)

References 276 publications

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“…However, metabolic disorders increase dramatically in postmenopausal women (Ford, 2005; Loucks et al, 2007). The loss of the reproductive steroid 17β-estradiol (E2) is, in part, the major cause of these effects especially on body weight gain (Rachoń and Teede, 2010; Stefanska et al, 2015). In ovariectomized rodent models, E2 regulates many aspects of energy homeostasis through both peripheral actions and central mechanisms (reviewed in Mauvais-Jarvis et al, 2013; Roepke, 2009; Shi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Yasrebi

Hsieh

Mamounis

et al. 2016

Molecular and Cellular Endocrinology

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Ghrelin’s receptor, growth hormone secretagogue receptor (GHSR), is highly expressed in the arcuate nucleus (ARC) and in neuropeptide Y (NPY) neurons. Fasting, diet-induced obesity (DIO), and 17β-estradiol (E2) influence ARC Ghsr expression. It is unknown if these effects occur in NPY neurons. Therefore, we examined the expression of Npy, Agrp, and GHSR signaling pathway genes after fasting, DIO, and E2 replacement in ARC and pools of NPY neurons. In males, fasting increased ARC Ghsr and NPY Foxo1 but decreased NPY Ucp2. In males, DIO decreased ARC and NPY Ghsr and Cpt1c. In fed females, E2 increased Agrp, Ghsr, Cpt1c, and Foxo1 in ARC. In NPY pools, E2 decreased Foxo1 in fed females but increased Foxo1 in fasted females. DIO in females suppressed Agrp and augmented Cpt1c in NPY neurons. In summary, genes involved in GHSR signaling are differentially regulated between the ARC and NPY neurons in a sex-dependent manner.

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Section: Introductionmentioning

confidence: 99%

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Yasrebi

Hsieh

Mamounis

et al. 2016

Molecular and Cellular Endocrinology

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“…Similar data relate to Polish women. Prevalence of metabolic syndrome (MS) after menopause, closely associated with obesity, is estimated at the level of 31-55%, depending on the criteria of MS, socioeconomic and environmental differences as well as on genetic and ethnic factors [3]. …”

Section: Introductionmentioning

confidence: 99%

Obesity in menopause – our negligence or an unfortunate inevitability?

Kozakowski¹,

Gietka-Czernel²,

Leszczyńska³

et al. 2017

130

120

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Numerous concerns about menopause exist among women, and fear of an increase in body weight is one of the most important of them. This paper presents an overview of current knowledge concerning the etiology of obesity related to menopause and about the mechanisms of its development, with particular regard to the hormonal changes that occur during this period of life. The role of estrogens in the regulation of energy balance and the effect of sex hormones on metabolism of adipose tissue and other organs are presented. The consequence of the sharp decline in the secretion of estrogens with subsequent relative hyperandrogenemia is briefly discussed. The main intention of this review is to clarify what is inevitable and what perhaps results from negligence and unhealthy lifestyles. In the last part of the paper the possibilities of counteracting the progress of adverse changes in body composition, by promoting beneficial lifestyle modifications and the use of hormonal substitution treatment, in cases where it is reasonable and possible, are described.

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“…These data are consistent with the Brazilian Society of Nephrology’s Dialysis Survey in 2014, which showed that 37% of dialysis patients were overweight or obese as a risk factor for CKD 49 . In addition, obesity is associated with MS, that is also a risk factor for the development of CKD 50 .…”

Section: Discussionmentioning

confidence: 99%

Health Conditions Associated with Overweight in Climacteric Women

Marques

Freitas

Popoff

et al. 2019

Preprint

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31This study aims to investigate the association between health conditions and 32 overweight in climacteric women assisted by primary care professionals. It is a cross-33 sectional study conducted with 874 women from 40 to 65 years of age, selected by 34 probabilistic sampling between August 2014 and August 2015. In addition to the outcome 35 variable, other variables such as overweight/obesity, sociodemographic, reproductive, 36 clinical, eating and behavioural factors were evaluated. Descriptive analyses of the 37 variables investigated through their frequency distributions were performed. Then, 38 bivariate analyses were performed through Poisson regression. For the multiple analyses, 39 the hierarchical Poisson regression was used to identify factors associated with 40 overweight/obesity in the climacteric period. The prevalence of overweight/obesity was 41 74%. Attending public school (PR: 1.30 -95% CI 1.14 -1.50), low schooling (PR: 1.11 42 -95% CI 1.01 -1.23), gout (PR: 1.18 -95% CI 1.16-1.44), kidney disease (PR: 1.18 -43 95% CI 1.05 -1.32), metabolic syndrome -MS (PR: 1.19 -95% CI 1.05 -1.34) and fat 44 intake (PR: 1.12 -95% CI 1.02 -1.23) were considered risk factors for overweight. 45Having the first birth after 18 years (PR: 0.89 -95% CI 0.82 to 0.97) was shown to be a 46 protective factor for overweight and obesity. The presence of overweight and obesity is 47 associated with socio-demographic, reproductive, clinical and eating habits. 48 49 Introduction 50Brazil has been presenting a rapid process of demographic and epidemiological 51 transition, leading to the frequent occurrence of chronic-degenerative diseases¹. The 52 increase in the prevalence of overweight, represented by overweight and obesity, among 53 the elderly female population raises great concern in developed and developing countries. 3 54Since overweight and obesity are risk factors for adverse health events 2 such as 55 disturbances in lipid and glycidic metabolism, psychological stress and sleep alterations, 56 with increasing risk of cardiovascular diseases 3 , musculoskeletal disease, acute 57 myocardial infarction 4 , cancer 5 and worse quality of life in comparison to those who were 58 satisfied with their body weight 6 . 59Overweight and obesity have become a public health problem in the world. The 60 projection for 2025 is that about 2.3 billion adults are overweight, and more than 700 61 million are obese. According to a study conducted in 2016, the rate of overweight among 62 Brazilian women is 50.5%, increasing this frequency with age and up to 64 years 7 . 63Epidemiological data are still scarce associating excess weight with behavioural 64 and clinical variables in climacteric women 8 , using probabilistic samples 9 . Considering 65 that climacteric is an important period of the women life cycle, and that this period is 66 related to the potential peak of fat mass and obesity in this group, the current study aimed 67 to investigate the association between health conditions and excess of weight ratio in 68 climacteri...

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Metabolic Syndrome and Menopause

Cited by 172 publications

References 276 publications

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol

Obesity in menopause – our negligence or an unfortunate inevitability?

Health Conditions Associated with Overweight in Climacteric Women

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