Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap

McIntyre, Roger S.; Rasgon, Natalie; Kemp, David E.; Nguyen, Ha Thi Thu; Law, Candy W. Y.; Taylor, Valerie H.; Woldeyohannes, Hanna O.; Alsuwaidan, Mohammad; Soczynska, Joanna K.; Kim, Byungsu; Lourenço, Maria Helena; Kahn, Linda S.; Goldstein, Benjamin I.

doi:10.1007/s11892-009-0010-0

Cited by 118 publications

(94 citation statements)

References 59 publications

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“…27 Such abnormalities are also observed in depressed patients of all ages, and can be considered as a neurobiological link between MetS and depression. 28,29 It is interesting that in our study high triglyceride levels was the MetS component with the most significant association with depressive symptoms. This highlights the relevance of the emergence of depressive symptoms in older adults to ensue lipid metabolism abnormalities.…”

Section: Discussionmentioning

confidence: 52%

Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study

Ruas

Diniz

Firmo

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To investigate the moderating effect of an increasing number of clustered metabolic syndrome (MetS) components on the association between MetS and depressive symptoms in a population-based cohort of older adults in Brazil.Methods: This analysis used data from the Bambuí Cohort Aging Study. Participants in this cross-sectional study comprised 1,469 community-dwelling older people aged X 60 years. Analyses were performed to assess both the association between depressive symptoms and each individual MetS component and the association between depressive symptoms and clustering of an increasing number of MetS components.

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Section: Discussionmentioning

confidence: 52%

Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study

Ruas

Diniz

Firmo

et al. 2016

Rev. Bras. Psiquiatr.

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“…49 There is evidence from several studies that the prevalence of MetS among adults with MDD or depressive symptoms is elevated. 50 Similarly, an increased hazard for MetS among people with BD has been documented across continents, countries, and cultures. 51,52 Each MetS component has been documented to be present at a higher rate than with matched people in the general population, with abdominal obesity being the most replicated finding.…”

Section: Traditional Cardiovascular Risk Factors In Relation To Mdd Amentioning

confidence: 94%

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

Goldstein¹,

Carnethon²,

Matthews³

et al. 2015

Circulation

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404

290

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Abstract-In the 2011 "Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children andAdolescents," several medical conditions among youth were identified that predispose to accelerated atherosclerosis and early cardiovascular disease (CVD), and risk stratification and management strategies for youth with these conditions were elaborated. Major depressive disorder (MDD) and bipolar disorder (BD) among youth satisfy the criteria set for, and therefore merit inclusion among, Expert Panel tier II moderate-risk conditions. The combined prevalence of MDD and BD among adolescents in the United States is ≈10%, at least 10 times greater than the prevalence of the existing moderate-risk conditions combined. The high prevalence of MDD and BD underscores the importance of positioning these diseases alongside other pediatric diseases previously identified as moderate risk for CVD. The overall objective of this statement is to increase awareness and recognition of MDD and BD among youth as moderate-risk conditions for early CVD. To achieve this objective, the primary specific aims of this statement are to (1) summarize evidence that MDD and BD are tier II moderate-risk conditions associated with accelerated atherosclerosis and early CVD and (2)

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“…[2,[4][5][6][7][8] Depression is also associated with significantly worse outcomes in a number of medical conditions, and depression is an independent risk factor for early mortality (even after accounting for sociodemographic factors, suicide, and biological and behavioral risk factors, such as smoking, alcohol, and physical illness). [9][10][11][12][13] Various explanations for ''accelerated aging'' in depression have been proposed, such as the ''glucocorticoid cascade'' hypothesis [14,15] and ''allostatic load.''…”

mentioning

confidence: 99%

Depression gets old fast: do stress and depression accelerate cell aging?

et al. 2010

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Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap

Abstract: The metabolic syndrome and its components are associated with depressive symptomatology. This article discusses the rate of co-occurrence and the points of pathophysiologic commonality between the metabolic syndrome and major depressive disorder.

Cited by 118 publications

References 59 publications

Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study

Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study

Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease

Depression gets old fast: do stress and depression accelerate cell aging?

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