Metabolic syndrome and lifestyle modification

Takahara, Mitsuyoshi; Shimomura, Iichiro

doi:10.1007/s11154-014-9294-8

Cited by 55 publications

(40 citation statements)

References 106 publications

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“…3 4 In addition to genetic features, obesogenic lifestyle defined by unhealthy diet and physical inactivity increase the risk for MeS. [5][6][7][8][9] The prevalence of MeS is increasing worldwide, along with the obesity epidemic and population ageing. 10 11 Estimates of MeS prevalence vary between 15% and 34% in adult populations, [12][13][14][15] and around 8-19% in reproductive-aged women in industrial countries.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome in Finnish women 7 years after a gestational diabetes prevention trial

et al. 2017

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BackgroundRisk for developing metabolic syndrome (MeS) after delivery is high among women with gestational diabetes mellitus (GDM), but little is known about development of MeS among women with risk factors for GDM during pregnancy. In the present study, we studied the prevalence of MeS 7 years postpartum among women with GDM risk factors during pregnancy, women with early GDM diagnosis and women without GDM risk factors. We also analysed the early pregnancy risk factors associated with MeS.MethodsA Finnish cluster randomised controlled GDM prevention trial was conducted in 2007–2009. The prevalence of MeS according to International Diabetes Federation criteria was determined in the follow-up study 7 years after original trial. Eligible participants (n=289) in 4 study groups (intervention (n=83) and usual care (n=87) with GDM risk factors; early GDM (n=51), and healthy control without GDM risk factors (n=68)) were evaluated for MeS. Binary logistic regression models were used to analyse risk factors associated with MeS.Results7 years postpartum, the MeS prevalence was 14% (95% CI 8% to 25%) in the intervention group; 15% (CI 8% to 25%) in the usual care group; 50% (CI 35% to 65%) in the early GDM group and 7% (CI 2% to 18%) in the healthy control group. OR for MeS in women with GDM risk factors did not differ from the healthy control group. Body mass index (BMI)-adjusted OR for MeS was 9.18 (CI 1.82 to 46.20) in the early GDM group compared with the healthy control group. Increased prepregnancy BMI was associated with MeS (OR, 1.17, CI 1.08 to 1.28, adjusted for group).ConclusionsIncreased prepregnancy BMI and early GDM diagnosis were the strongest risk factors for developing MeS 7 years postpartum. Overweight and obese women and especially those with early GDM should be monitored and counselled for cardiometabolic risk factors after delivery.

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Section: Introductionmentioning

confidence: 99%

Metabolic syndrome in Finnish women 7 years after a gestational diabetes prevention trial

et al. 2017

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“…We believe that the pathological mechanism of obesity leading to epidural fat deposition may be the disorder of glucose and lipid metabolism rstly. Based on the close relationship between visceral fat accumulation and abnormal lipid metabolism [29][30][31], it is speculated that SEL may be another site of systemic fat accumulation caused by abnormal lipid metabolism; Secondly, high BMI and obesity are considered as a chronic in ammatory state, which may be one of the causes of excessive growth of adipose tissue in the spinal canal. Hypertrophic adipocytes continued to express pro-in ammatory cytokines, tumor necrosis factor TNFα, interleukin-1β, etc.…”

Section: Discussionmentioning

confidence: 99%

Obesity is a Risk Factor for Epidural Lipomatosis: A Meta-analysis

Zhang

Yuan

et al. 2020

Preprint

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Background: Many studies have investigated the relationship between spinal epidural lipomatosis and obesity, no meta-analysis of studies have provided definitive evidence. To summarize the evidence of associations between obesity factors and spinal epidural lipomatosis (SEL) and to evaluate the strength and validity of these associations. Methods: Electronic databases such as Wiley Online Library, PubMed, Embase, Cochrane Library were searched and manual retrieval of references, the time limit was from the establishment of the database to May 2020. The included literature was case-control studies that reported body mass index (BMI) and SEL correlation, and excluded any primary and secondary tumors or other compression diseases in the spinal canal. Methodological quality evaluations of the included studies were assessed using the bias risk assessment tool recommended by the Cochrane Guidelines. The RevMan 5.3 software was used for meta-analysis. Results: Finally, ten studies were included for systematic review, all of which were observational studies with mixed bias risk. These studies involved 1,541 patients, with an average age of 54.9 to 73.6 years, and 60.2 percent of the participants were male. The sample sizes for the included studies ranged from 28 to 398. The results of meta-analysis showed that high BMI was one of the factors affecting SEL. All reviews had a high risk of bias, and the most common source of bias was that there was no strict unified case diagnosis standard between researches, and some studies (four items) did not clearly describe the confounders that they controlled. Conclusions: We suggest that physicians should consider obesity as a factor leading to SEL, and to control body mass index actively should be considered as the preferred treatment strategy before surgical intervention is conducted.

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“…Health-related lifestyle can be a very effective strategy that is being used mainly in the prevention of chronic degenerative diseases [4]. Some studies have already shown positive associations between health-related lifestyle and components of metabolic syndrome improvement: systemic arterial blood, hypertriglyceridemia, high blood glucose and HDL-c reductions [5,6] in a study followed for a mean of 3.2 years after random assignment to intensive lifestyle intervention, metformin therapy, or placebo the incidence of the metabolic syndrome was reduced by 41% in the lifestyle group (p < 0.001) and by 17% in the metformin group (p = 0.03) compared with placebo [6]. In addition, cardiac rehabilitation programs are considered good strategies for overall survival; it includes physical training, eating habits reeducation, smoke cessation and stress management [7].…”

Section: Open Accessmentioning

confidence: 99%

Short and long term effect of treatment non-pharmacological and lifestyle in patients with metabolic syndrome

Brandão

Silva

Lima

et al. 2020

Diabetol Metab Syndr

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Background: Metabolic syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors usually related to central fat deposition, insulin resistance, hypertension and dyslipidemia. It is associated with accelerated atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction, increasing overall mortality. The objective to evaluate the short and long term effect of the comprehensive cardiac rehabilitation program and intensive lifestyle intervention in metabolic syndrome patients. Methods: This is longitudinal interventional study. All patients underwent a 20-session cardiac rehabilitation program with aerobic and resisted exercises as well as an educational program for lifestyle changes and follow up 1 year. Results: Forty seven patients participated in the present study, but only 28 concluded the follow up. 77.7% were females and the majority was older than 60 years (63.1%). After cardiac rehabilitation, the percentage of overweight (0.04) patients who controlled the SBP (0.04) increased, and obesity levels I and II were reduced, as well as a significant reduction in total cholesterol and triglycerides (0.01 and 0.05), all of these variables remained similar after 1 year of follow-up. After cardiac rehabilitation all participants were practicing the five factors of healthy lifestyle, and reduced to 73% after follow up. Conclusion: A comprehensive cardiac rehabilitation program and lifestyle change is an effective approach in the treatment of patients with MS mainly, it has positive short and long term effects on weight control, reducing total cholesterol and triglycerides.

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Metabolic syndrome and lifestyle modification

Cited by 55 publications

References 106 publications

Metabolic syndrome in Finnish women 7 years after a gestational diabetes prevention trial

Metabolic syndrome in Finnish women 7 years after a gestational diabetes prevention trial

Obesity is a Risk Factor for Epidural Lipomatosis: A Meta-analysis

Short and long term effect of treatment non-pharmacological and lifestyle in patients with metabolic syndrome

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