Metabolic Syndrome and Cognitive Performance Among Chinese ≥50 Years: A Cross-Sectional Study with 3988 Participants

Chen, B; X, Jin; Guo, Renhua; Z, Chen; Hou, Xiaotong; Gao, Fang; Zhang, Y; Zheng, Shuyue; Fu, Cuiping; Xue, Fu‐Shan; Huang, Niu

doi:10.1089/met.2015.0094

Cited by 22 publications

(13 citation statements)

References 29 publications

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“…[24] Age and abdominal obesity were signi cant risk factors for cognitive decline. [16] Studies have failed to show any association between Mets and cognitive impairment; [14,25] however, most studies have shown that participants with metabolic syndrome are associated with increased odds of cognitive impairment, [12,20,24,26,27] which is consistent with our results. Although most studies have shown that Mets and its components play roles in cognitive decline, other studies have suggested that late-life Mets has a protective effect on cognitive function.…”

Section: Discussionsupporting

confidence: 89%

The Association of Metabolic Syndrome and Cognitive Impairment in Jidong of China: A Cross-Sectional Study

Wang

Long

Ding³

et al. 2020

Preprint

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Background: Metabolic syndrome (Mets) is prevalent in the general population and has been reported to be an independent risk factor for cognitive impairment. This study aimed to investigate the association of Mets with the risk of cognitive impairment.Methods:We studied 5,854 participants from the Jidong community. Cognitive function was assessed by the Mini-Mental State of Examination (MMSE) scale. Mets was diagnosed according to the International Diabetes Federation criteria. We used logistic regression analysis to investigate the association of metabolic syndrome with the risk of cognitive impairment.Result: Among the 5,854 adults included in the study, the age mean (SD) of age was 44 (13.57) years, and 2,916 (50.34%) were male. There was a higher (56.03%) cognitive impairment incidence rate among participants with Mets than among those without Mets. In addition, there was a significant association between Mets and cognitive impairment (OR: 2.39, 95% CI: 2.00 - 2.86, P < 0.05) after adjusting for potential confounders, including age, gender, education level, marital status, smoking and alcohol consumption status. Regarding the 5 Mets components, abdominal obesity and elevated blood pressure were associated with the risk of Mets (OR: 1.36, 95% CI: 1.09-1.70, P < 0.001; OR: 1.32, 95% CI: 1.07 - 1.63, P < 0.05). Moreover, the strongest statistical correlation (adjusted OR: 1.86, 95% CI: 1.22 - 2.83, P < 0.05) was found when the number of Mets components was three.Conclusion: Our study suggested that Mets was associated with cognitive impairment and that abdominal obesity and hypertension were associated with an increased risk of cognitive impairment.

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Section: Discussionsupporting

confidence: 89%

The Association of Metabolic Syndrome and Cognitive Impairment in Jidong of China: A Cross-Sectional Study

Wang

Long

Ding³

et al. 2020

Preprint

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“…For example, it was estimated that 11 million deaths world-wide can be attributed to MetS annually [3]. Although MetS has traditionally primarily been linked to CVD, studies suggest that MetS [4–7] and metabolic abnormalities more generally [7–9] may also be related to cognitive impairment as a type of organ dysfunction that burdens the global economy to extents similar to CVD [10]. Chronically elevated blood glucose levels, for instance, have consistently been associated with an increased risk of future cognitive impairment [11].…”

Section: Introductionmentioning

confidence: 99%

Associations of the metabolic syndrome and its components with cognitive impairment in older adults

et al. 2019

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Background The metabolic syndrome (MetS) is an established cardiovascular risk factor. Here, we investigated its role in cognitive impairment. Methods Baseline data from 202 participants (aged 65 to 87 years) of the BioCog study were used. All were free of clinical dementia (MMSE≥24/30). Cognitive impairment was defined as the lowest tertile of a cognitive summary score. Multiple logistic regression analyses examined associations of body mass index (BMI), triglycerides (TG), high-density lipoprotein (HDL-C), glucose and glycated hemoglobin A1c (HbA1c) levels with the odds of cognitive impairment. MetS was defined as ≥3 of its 5 components obesity (BMI ≥ 30 kg/m 2 ), elevated TG (TG ≥1.7 mmol/L), reduced HDL-C (males: < 1.0 mmol/L; females: < 1.3 mmol/L), elevated glucose (glucose ≥5.5 mmol/L and/or diagnosed diabetes) and elevated blood pressure (history of hypertension). Analyses controlled for age, sex and smoking history. Results Lower HDL-C was significantly associated with a higher odds of cognitive impairment (OR 2.70 per 1 mmol/L reduction; 95% CI 1.25, 5.56; p = 0.011), whereas BMI, TG, glucose and HbA1c were not (all p > 0.05). Results for HDL-C were similar when HDL-C, glucose, BMI and TG were entered into a single model (OR 2.56 per 1 mmol/L reduction, 95% CI 1.09, 5.88, p = 0.031) and when cerebrovascular disease and coronary heart disease were additionally controlled for (OR 2.56 per 1 mmol/L reduction, 95% CI 1.06, 6.25, p = 0.036). Among the 5 MetS components, participants with elevated TG were at 2-fold increased odds of impairment (OR 2.09, 95% CI 1.08, 4.05, p = 0.028) including when the remaining 4 MetS components were entered (OR 2.23, 95% CI 1.07, 4.65, p = 0.033), but the finding was no longer statistically significant when cerebrovascular disease and coronary heart disease were additionally controlled for ( p = 0.11). Presence of MetS and of obesity, reduced HDL-C, elevated glucose or elevated blood pressure were not significantly associated with impairment (all p > 0.05). Conclusion Our findings support low HDL-C as an independent risk marker of cognitive impairment in older age. The need for research into mediatory and confounding factors, and re-evaluation of traditional cut-off points is highlighted. Trial registration The study was registered on 15th October 2014 at clinicaltrials.gov ( NCT02265263 ).

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“…Adverse relationship between Digit symbol test scores and increasing numbers of MetS constituents has also been reported ( Tsai et al., 2016 ). However, other studies did not observe an association between presence of MetS and cognitive performance in the older population ( Chen et al., 2016 ).…”

Section: Discussionmentioning

confidence: 79%

Contribution of Components of Metabolic Syndrome to Cognitive Performance in Middle-Aged Adults

Bahchevanov

Dzhambov

Chompalov

et al. 2020

Archives of Clinical Neuropsychology

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Introduction Metabolic syndrome (MetS) has been associated with impaired cognition in different cognitive domains. This study investigated the association between MetS and cognitive functioning in middle-aged Bulgarians across different definitions of MetS severity. Material and Methods Our cross-sectional sample included 112 participants (67 free of MetS and 45 with MetS) with a mean age of 50.04 ± 3.31 years. The following MetS variables were considered—presence of MetS, continuously measured MetS components, dichotomized MetS components, number of MetS components present, and Metabolic Syndrome Severity Score (MSSS). Participants’ cognitive performance was assessed using the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD-NB). We employed multivariate regression models to investigate the associations between different measures of MetS severity and CERAD-NB total and subtest scores. Results Bivariate analyses showed that the CERAD-NB total score was significantly higher in women, participants with a university degree, those with normal blood pressure, normal waist circumference, and low triglyceride levels, compared with their counterparts. MetS participants had lower CERAD-NB total score (78.87 ± 6.89 vs. 84.97 ± 7.84) and specifically performed poorer on the subtest Word List Recall (7.16 ± 1.52 vs. 7.99 ± 1.52). These findings persisted after controlling for age, gender, and education. Next, generalized linear regression indicated that the CERAD-NB total score was lower in participants with MetS (β = −4.86; 95% confidence interval [CI]: −7.60, −2.11), those with more MetS components (β = −8.31; 95% CI: −14.13, −2.50 for fours vs. 0 components) and with an increase in MSSS (β = −3.19; 95% CI: −4.67, −1.71). Hypertension independently contributed to lower CERAD-NB total score (β = −4.00; 95% CI: −6.81, −1.19). Conclusions Across several definitions, MetS was associated with lower cognitive functioning, and MetS severity appeared to be a better predictor than most MetS components. Recognizing and reducing severity of MetS components might be helpful in supporting cognitive functioning. Further longitudinal research is needed to shed more light on the relationship between MetS and cognitive functioning across the life span.

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Metabolic Syndrome and Cognitive Performance Among Chinese ≥50 Years: A Cross-Sectional Study with 3988 Participants

Abstract: In our study, MetS is not associated with cognitive performance in elderly Chinese population. However, elderly Chinese with diabetes would have lower cognition function, and the dyslipidemia might be reversely associated with the cognitive function.

Cited by 22 publications

References 29 publications

The Association of Metabolic Syndrome and Cognitive Impairment in Jidong of China: A Cross-Sectional Study

The Association of Metabolic Syndrome and Cognitive Impairment in Jidong of China: A Cross-Sectional Study

Associations of the metabolic syndrome and its components with cognitive impairment in older adults

Contribution of Components of Metabolic Syndrome to Cognitive Performance in Middle-Aged Adults

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