Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure

Kawamoto, Ryuichi; Tomita, Hitomi; Oka, Yuichiro; Ohtsuka, Nobuyuki; Kamitani, Atsushi

doi:10.5551/jat.12.268

Cited by 36 publications

(29 citation statements)

References 27 publications

(21 reference statements)

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“…23,34 More recently the role of hypertension, in particular of the blood pressure variability during 24 h, in addition to that of the duration of hypertension 35,36 was strongly supported, even in subjects with metabolic syndrome. 37 The present study is in agreement with these observations, showing that the association of metabolic abnormalities to hypertension adds only a further small impairment to that induced by hypertension. Carotid diameter, on the other hand, was similar in hypertensive patients, with and without MS, and in normotensive subjects.…”

Section: Discussionsupporting

confidence: 82%

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

et al. 2007

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High blood pressure (BP) is one of the crucial determinants of the metabolic syndrome (MS). The extent to which MS, diagnosed according to the criteria of the International Federation of Diabetes, impacts on cardiovascular organ damage, independently of BP, is debated. Three hundred and forty hypertensive patients and 100 normotensive controls underwent the following procedures: (1) physical examination and resting BP measurements, (2) 24 h ambulatory BP monitoring, (3) laboratory routine examination, (4) echocardiography, (5) carotid ultrasonography and (6) ankle-brachial BP index. The syndrome was found in 104 of the 340 hypertensive patients (30.6). In comparison to those without MS, those with MS had significantly higher prevalence of left ventricular (LV) hypertrophy by mass/height 2.7 criteria (46 vs 42%, Po0.01) but not by LV mass/body surface criteria (30 vs 31%); the ratio between early-to-late peak velocities of the LV filling waves (E/A) was higher (E/ A ¼ 0.9970.14 vs 0.8970.15, Po0.01) and left atrium was larger (3.870.3 vs 3.570.5 cm, Po0.01). Both hypertensive groups had significantly greater LVM and carotid intima-media thickness than normotensives, without between-group-difference. In this hypertension outpatient clinic almost one-third hypertensive patients have MS. They show a deterioration in structure and function of the heart in comparison to hypertensive patients without MS, but no difference was detected in the carotid and peripheral arterial circulation.

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Section: Discussionsupporting

confidence: 82%

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

et al. 2007

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“…[150][151][152][153][154][155][156][157][158][159] This relationship to carotid atherosclerosis is strengthened in proportion to the number of components of metabolic syndrome (p<0.001) 160-162 but appears strongest for hypertension. 152,155,156,161,163,164 Abdominal adiposity bears a graded association with the risk of stroke and TIA independent of other vascular disease risk factors. 165 Physical inactivity is a well-documented, modifiable risk factor for stroke, but the risk reduction associated with treatment is unknown.…”

Section: Risk Factor Managementmentioning

confidence: 99%

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease: Executive summary

Brott

Halperin

Abbara

et al. 2011

Cathet Cardio Intervent

180

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“…On the other hand, MS subjects showed a high incidence of abnormal plaque quality, such as plaque eccentricity, calcification and lipid pools. Therefore, even though each component of MS plays an important role in the progression of atherosclerosis [21][22][23][24] , the Japanese criteria of MS, which stress visceral fat accumulation, is a reasonable definition to detect the population at high risk for acute coronary syndrome, and we should detect and treat MS subjects as early as possible. Some reports have emphasized that insulin resistance is a central factor in the pathogenesis of MS 25,26) , and insulin resistance is also known to play an important role in the progression of coronary atherosclerosis [27][28][29][30] .…”

Section: Significance Of Ms For Plaque Formation In Early Stage Coronmentioning

confidence: 99%

Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis

Hatori

Takahashi

Iizuka

et al. 2007

JAT

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Aim: Recent clinical studies using intra-vascular ultrasound have clarified that coronary artery plaque already exists in subjects with normal coronary artery which is diagnosed by coronary angiography; furthermore, culprit lesion on acute coronary syndrome often occurs in mild to moderate angiographical stenotic lesion. The aim of this study is to clarify relationship between metabolic syndrome and early stage coronary atherosclerosis using a 3-dimensional intra-vascular ultrasound. Methods: 70 subjects with normal coronary artery diagnosed by coronary angiography were enrolled. Proxymal range of left anterior descending coronary artery was observed by intra-vascular ultrasound using autopullback methods. Results: Subjects with metabolic syndrome had significantly high percent plaque volume (31 8% vs 21 8%, p 0.0001) and frequently detected abnormal plaque quality such as eccentricity, calcification and lipid pool into plaque than those without metabolic syndrome. Multivariate analysis showed that serum adiponectin concentration was the most strongest variable for percent plaque volume (t value 3.0, p 0.01). On the other hand, subjects with hypoadiponectinemia were detected high incidence of mild calcification into plaque.

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Metabolic Syndrome and Carotid Atherosclerosis: Role of Elevated Blood Pressure

Abstract: It is not known whether subjects with metabolic syndrome and elevated blood pressure are at the same cardiovascular risk as subjects with metabolic syndrome but without elevated blood pressure.

Cited by 36 publications

References 27 publications

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS Guideline on the Management of Patients With Extracranial Carotid and Vertebral Artery Disease: Executive summary

Relationship between Metabolic Syndrome and Early Stage Coronary Atherosclerosis

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