Metabolic Syndrome Among Persons With Schizophrenia and Other Psychotic Disorders in a General Population Survey

Suvisaari, Jaana; Saarni, Samuli I.; Perälä, Jonna; Suvisaari, Janne; Härkänen, Tommi; Lönnqvist, Jouko; Reunanen, Antti

doi:10.4088/jcp.v68n0711

Cited by 93 publications

(78 citation statements)

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“…This suggests that total participants group without metabolic syndrome showed more cardiovascular stability and ability of the ANS to control the body system than total participants group with metabolic syndrome. As expected, H participants group were significantly associated with SDNN (AOR, 2.13; 95% CI, Program (Grundy et al, 2004), the prevalence rate of metabolic syndrome in hospitalized patients with schizophrenia was 19.9%, in same inpatient population were 36-37%, which was higher than that of general populations (Lee et al, 2004;Suvisaari et al, 2007). In Korea, the prevalence of metabolic syndrome was 16.0% in men and 10.7% in women aged 30-80 years (Oh, Hong, Sung, & Barrett-Con- These finding has implications with the fact that significantly higher LF and HF indices shown in S participants than that of healthy participants in this study may be explained in part by the use of antipsychotic drugs that all S participants were taking.…”

Section: Discussionsupporting

confidence: 64%

Heart Rate Variability and Metabolic Syndrome in Hospitalized Patients with Schizophrenia

et al. 2011

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Purpose: Reduced heart rate variability significantly increases cardiovascular mortality. Metabolic syndrome increases the cardiac autonomic dysfunction. Recently, increasing cardiovascular mortality has been reported in patients with schizophrenia. This study was done to compare heart rate variability between adults with and without schizophrenia and to compare the relationship of heart rate variability to metabolic syndrome in hospitalized patients with schizophrenia. Methods: This was a descriptive and correlational study in which 719 adults without schizophrenia and 308 adults with schizophrenia took part between May and June 2008. We measured the following: five-minute heart rate variability; high-frequency, low-frequency, the ratio of low-frequency to high-frequency, and the Standard Deviation of all the normal RR intervals. Data was also collected on metabolic syndrome, abdominal obesity, triglycerides, HDL cholesterol, blood pressure and fasting glucose. Results: The Standard Deviation of all the normal RR intervals values of heart rate variability indices were 1.53±0.18. The low-frequency and high-frequency values of heart rate variability indices were significantly higher in hospitalized patients with schizophrenia (3.89±1.36; 3.80±1.20) than those in the healthy participants (2.20±0.46; 2.10±0.46). There were no significant differences between the schizophrenic patients with and without metabolic syndrome. Conclusion: The results of this study indicate that schizophrenia patients have significantly lower cardiac autonomic control, but they have significantly higher low-frequency and high-frequency values than those of healthy adults. Use of antipsychotic drug may affect the autonomic nervous system in schizophrenic patients. Metabolic syndrome was not associated with cardiac autonomic control in schizophrenia patients.

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Section: Discussionsupporting

confidence: 64%

Heart Rate Variability and Metabolic Syndrome in Hospitalized Patients with Schizophrenia

et al. 2011

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“…The association with hypertension is a controversial issue, with some studies fi nding a decreased risk of hypertension in persons with schizophrenia compared with the general population. [5] The increased risk of cardiovascular mortality may also be a result of increased prevalence of metabolic syndrome. There is a fourfold risk of metabolic syndrome in young patients with schizophrenia compared with the general population, [17] and it has been suggested that around 50% of persons with schizophrenia may be affected.…”

Section: Epidemiologymentioning

confidence: 99%

“…[15] In general, the risk of metabolic syndrome is much higher among young patients than in the general population; but in patients aged over 55 years, the prevalence of metabolic syndrome in patients with schizophrenia may not differ from that in the general population. [5] Obesity and schizophrenia Overweight and obesity is a particular problem in individuals with schizophrenia compared with the general population. [17] [18,19] but existing studies show that they have a strong association with production of metabolic syndrome in patients treated with these agents [ Table 2].…”

Section: Epidemiologymentioning

confidence: 99%

“…A number of abnormal lipid profiles have been reported in the context of treatment with second-generation antipsychotics, usually in association with increased body mass. [5] Elevated fasting plasma triglyceride is an important signal for potential insulin resistance.…”

Section: Epidemiologymentioning

confidence: 99%

“…First-generation antipsychotics or typical antipsychotics have also been linked to increased risk of developing this complication. [5] In addition, smoking, poor diet, reduced physical activity and alcohol or drug abuse are prevalent in people with schizophrenia and contribute to the overall cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

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