Metabolic Syndrome After Liver Transplantation: Five-Year Prevalence and Risk Factors

Expert consensus on management of metabolic disease in Chinese liver transplant recipients

“…The risk of hypertension caused by CsA is higher than that caused by TAC[ 46 ]. However, the regimen of MPA represented by MMF combined with CNI reduction regimen can significantly reduce the risk of new-onset hypertension after liver transplantation, and the glucocorticoid-free or early withdrawal regimen can also significantly reduce the incidence of new-onset hypertension after liver transplantation[ 47 - 50 ].…”

Hepatology Clinical

“…Introduction : Post‐liver transplantation metabolic syndrome (PTMS) is a significant independent risk factor for cardiovascular disease. Risk factors for developing PTMS include pre‐transplant diabetes, obesity, and increasing age . Low muscle mass, excess adipose tissue, and poor cardiorespiratory fitness are risk factors for metabolic syndrome in the general population that have not been evaluated in the liver transplant setting .…”

Assessment of sarcopenia, hepatic function and clinical outcomes in liver transplantation

“…207 To help predict post-transplant metabolic complications, some authors have examined pretransplant variables and found the presence of pre-transplant obesity to be a strong predictor of PTMS, along with diabetes and dyslipidaemia. 208,209 However, the prognostic utility of pre-transplant body composition to predict PTMS, such as excess visceral adipose tissue (VAT), is currently unknown. Prior studies have identified that as visceral adipose tissue increases, there is a progressive risk of derangement in metabolic risk factors.…”

“…205 Previous studies have identified pre-transplant risk factors for PTMS including pre-existing cardiometabolic disease and higher body mass index. 208,209 The risk associated with visceral distribution of adipose tissue is relatively unexplored. In Chapter 6, we conducted a retrospective study of liver transplant recipients, and identified that pretransplant CT measured visceral adipose tissue was an independent predictor of early PTMS.…”

“…208,209,254,255 In addition, patients with alcoholic liver disease appear to be more likely to develop post-transplant diabetes and dyslipidaemia at 1 year. 208,256 Pre-transplant adipose tissue has not been evaluated as a predictor of PTMS. Excess visceral adipose tissue (VAT) has been linked with disturbances in metabolic risk factors in population studies.…”