Metabolic syndrome: A novel high-risk state for colorectal cancer

Ishino, Kousuke; Mutoh, Michihiro; Totsuka, Yukari; Nakagama, Hitoshi

doi:10.1016/j.canlet.2012.10.012

Cited by 47 publications

(53 citation statements)

References 89 publications

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“…Westernized life style and diet are thought to be some of the major reasons for the observed increase in incidence of CRC in Korea and in other developed countries [2][3][4]. Numerous studies have shown that colorectal carcinogenesis is associated with metabolic disorders, such as obesity, metabolic syndrome, and diabetes mellitus; however, the exact mechanisms are currently unclear [5][6][7]. The incidence of diabetes mellitus has been increasing vastly in most countries, including Korea [8,9], and it undoubtedly represents one of the most challenging health issues of the 21st century [10].…”

Section: Introductionmentioning

confidence: 99%

Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: The Korean Cancer Prevention Study-II

Kim

Linton

2014

Metabolism

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Section: Introductionmentioning

confidence: 99%

Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: The Korean Cancer Prevention Study-II

Kim

Linton

2014

Metabolism

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“…Of the 4303 candidates, we excluded participants who met following criteria: [1] missing serum ferritin result, [2] having haemochromatosis caused by the abnormal high level of serum ferritin, [3] knowing a past history of malignancy, liver disease, nephropathy, dyslipidemia or/and thyroid parafunction, [4] alcohol intake 12 h before physical examination. In the end, 2417 unrelated participants (56.17%) aged 20–73 years old were enrolled into the cross-sectional study.…”

Section: Methodsmentioning

confidence: 99%

“…Based on the cross-sectional study, we excluded participants who met following criteria: [1] diagnosed as baseline MetS, [2] missing communication, [3] unwillingness or having some diseases unsuited to participate in the follow-up, 1109 participants (45.88%) were selected into the longitudinal study, and the follow-up duration is 4 years.…”

Section: Methodsmentioning

confidence: 99%

“…There is much information indicating that each abnormality involved in the MetS can increase the morbidity and mortality of cardiovascular diseases and cancers [2-4]. From the studies of investigating factors associated with MetS, we have known that multiple factors, such as high uric acid level and inflammatory cytokines, are closely associated with MetS [5,6].…”

Section: Introductionmentioning

confidence: 99%

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High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population

Tang

Liu

Tang

et al. 2015

Diabetol Metab Syndr

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BackgroundElevated serum ferritin levels have been reported to contribute to metabolic syndrome (MetS). We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chinese male adult population.MethodThe data came from the 2009–2013 Fangchenggang Area Males Health and Examination Survey (FAMHES). We combined a cross-sectional study of 2417 males and a longitudinal study of 857 males who participated in the FAMHES.ResultThe serum ferritin level of MetS was higher than that of nonMetS (median and percentiles 25–75: 447.4 (294.1-612.4) vs. 302.4 (215.0-435.8) ng/ml, p < 0.01). A positive correlation between ferritin concentrations and blood pressure (Systolic BP: R = 0.110, Diastolic BP: R = 0.158), waist circumference (R = 0.333), fasting glucose (R = 0.089), triglyceride (R = 0.315) and low high-density lipoprotein cholesterol (R = 0.130) was significant (all p < 0.001). Compared with the level of ferritin in the group with no MetS component, the group with all five MetS components had a higher ferritin level (554.7 (340.1-606.4) vs. 274.2 (198.2-384.4) ng/ml). The odd radio (OR) was higher for MetS in the highest ferritin quartile (OR = 2.29, 95% CI = 1.47-3.54) compared with the lowest ferritin quartile after adjustment for multi-factors. After 4-year follow up, 79 subjects newly diagnosed with MetS in 857 cohort male participants in 2013. Compared with the lowest ferritin quartile, the RR of the highest ferritin quartile was 2.55 (95% CI = 1.30-5.00) after multiple adjustments (p < 0.01).ConclusionOur findings confirm that the serum ferritin level is associated with the independent components of MetS, and elevated ferritin level is an independent risk factor for MetS development in the Chinese male population during the 4-year follow-up period.

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“…Several pathophysiological mechanisms, such as the emergence of insulin resistance, state of chronic inflammation and the induction of oxidative stress, may be involved in colorectal carcinogenesis in patients with Mets (3–5). For example, diabetic patients, who frequently present with Mets in addition to insulin resistance, are considered as a high-risk group for CRC development (1–5).…”

Section: Introductionmentioning

confidence: 99%

Preventive effects of the angiotensin-converting enzyme inhibitor, captopril, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats

et al. 2014

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Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive drug, on the development of azoxymethane (AOM)-induced colonic premalignant lesions, aberrant crypt foci (ACF), in SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) diabetic and hypertensive rats. Male 6-week-old SHRSP-ZF rats were administered two, weekly intraperitoneal injections of AOM (20 mg/kg body weight). Following the second injection, the rats received drinking water containing captopril (8 mg/kg/day) for two weeks. At sacrifice, captopril administration significantly lowered the blood pressure and reduced the total number and size of ACF compared with those observed in the untreated group. The serum levels of angiotensin-II and the expression levels of ACE and angiotensin-II type 1 receptor mRNA on the colonic mucosa decreased following captopril treatment. Captopril also reduced the urinary 8-hydroxy-2′-deoxyguanosine levels and the serum derivatives of reactive oxygen metabolites levels, both of which are oxidative stress markers, but increased the mRNA levels of catalase, an antioxidant enzyme, in the colonic epithelium. Moreover, the expression levels of tumor necrosis factor-α, interleukin-18, monocyte chemoattractant protein-1, inducible nitric oxide synthase, vascular endothelial growth factor and proliferating cell nuclear antigen mRNA in the colonic epithelium were decreased significantly following captopril administration. These observations suggested that captopril prevents the development of ACF by inhibiting renin-angiotensin system activation and attenuating inflammation and oxidative stress in SHRSP-ZF rats. Therefore, targeting Mets-related pathophysiological conditions, including renin-angiotensin system activation, may be an effective strategy to prevent colorectal carcinogenesis in patients with Mets, particularly those with hypertension.

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Metabolic syndrome: A novel high-risk state for colorectal cancer

Cited by 47 publications

References 89 publications

Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: The Korean Cancer Prevention Study-II

Association between fasting serum glucose levels and incidence of colorectal cancer in Korean men: The Korean Cancer Prevention Study-II

High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population

Preventive effects of the angiotensin-converting enzyme inhibitor, captopril, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats

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