Metabolic Studies on Neoplasm of Bone With the Aid of Radioactive Strontium*

Establishing a Clinical Role for Bone Scans (perspective on “Early Diagnosis of Metastatic Bone Cancer by Photoscanning with Strontium-85” J Nucl Med. 1964;5:168–179)

“…Gynning et al have confirmed these findings and have shown that Sr-85 can also be demonstrated to localize to a greater extent in tumor-laden bone than in normal osseous tissue, even when x-rays of the involved part are apparently normal (16). It is known that radiostrontium accumulates to a considerable degree in osteogenic sarcoma and Ewing's tumor as well (17). Fleming and his associates were the first to utilize the photoscanning technique for the display of strontium deposition in human bone (18).…”

Techniques of Histo- and Cytochemistry: A Manual of Morphological and Quantitative Micromethods for Inorganic, Organic and Enzyme Constituents in Biological Materials

“…Thus its distribution was studied in bones by Dols et al (1938) and Belanger and Leblond (1946), in tomato fruits by Arnon et al (1940), in squash plants by Colwell (1942), and in insects by Lindsay and Craig (1942). "Autographs" have been obtained in bone studies with radioactive calcium and strontium by Pecher (1941) and Treadwell et al (1942). The distribution of radioactive lead in the animal body was investigated by Behrens and Baumann (1933a,b), and thyroid studies were carried out with radioactive iodine by Hamilton et al ( 1940) , Gorbman and Evans (1941), and Belanger and Leblond (1946).…”

Treatment with radioactive 89strontium for patients with bone metastases from prostate cancer

“…This therapy consists of the intravenous administration to the patient of a bone‐seeking, radioactive pharmaceutical, producing ‘targeted’ irradiation. Already in the 1930s and 1940s, 32 P and 89 Sr were known to alleviate pain in patients with cancer [20]. Recently, other radiopharmaceuticals have been successfully applied, e.g.…”