Metabolic studies of acetoacetate, pyruvate, lactate and citrate in uremic acidosis

Campanacci, L; Guarnieri, Gabriella; Siliprandi, N.; Fiaschi, E

doi:10.1016/0009-8981(68)90169-1

Cited by 15 publications

(6 citation statements)

References 8 publications

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“…Lactate and pyruvate levels are not increased by uraemia per se [30]. Lactate absorbed from the dialysis fluid may contribute to the higher lactate levels during peritoneal dialysis.…”

Section: Discussionmentioning

confidence: 93%

Carbohydrate and Lipid Metabolism during Continuous Ambulatory Peritoneal Dialysis (CAPD): The Effect of a Single Dialysis Cycle

et al. 1983

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The effect on hormonal status and intermediary metabolism of a single 6 h dialysis cycle at two different concentrations of dialysate glucose was investigated in six patients on continuous ambulatory peritoneal dialysis. The basal blood glucose level was elevated by 0.5 mmol/l, associated with a threefold increase in basal serum insulin compared with seven normal controls. Blood glucose and serum insulin rose further during dialysis, particularly with hypertonic (215 mmol of glucose/l) dialysis fluid and levels remained high for 6 h after the onset. Plasma glucagon concentrations were 2.7-fold increased and did not decrease to normal during dialysis. Concentrations of the gluconeogenic precursors lactate and alanine were consistently raised, and levels of circulating non-esterified fatty acids and ketone bodies were lowered, particularly with hypertonic dialysis fluid. The long-term effects of sustained hyperinsulinaemia, including suppression of lipolysis and ketogenesis, require further investigation.

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“…Lactate and pyruvate levels are not increased by uraemia per se [30]. Lactate absorbed from the dialysis fluid may contribute to the higher lactate levels during peritoneal dialysis.…”

Section: Discussionmentioning

confidence: 93%

Carbohydrate and Lipid Metabolism during Continuous Ambulatory Peritoneal Dialysis (CAPD): The Effect of a Single Dialysis Cycle

et al. 1983

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“…It is possible that in chronic uremic patients the pyruvate is not adequately oxidized in the citric acid cycle, owing either to a reduced activity of the cycle [4], or to a decreased acetyl-coenzyme A formation [17], The lower 2-oxoglutarate levels found during the test in the chronic uremic patients is a further proof of a reduced entry of the pyruvate into the citric acid cycle. Fig.3.…”

Section: Discussionmentioning

confidence: 99%

“…Normal [7] or increased [2, 11] levels of blood pyruvate have been found in uremia by different authors. In previous papers we have reported normal pyruvate con centrations, both in blood [4] and in muscle [12] of uremic patients.In order to examine the pyruvate metabolism in uremia, we have now made use of the pyruvate tolerance test, following the procedure described by M o o r i i o u s e [15] in diabetic patients. Should the pyruvate tolerance be de creased, a disorder of the citric acid cycle might be supposed.…”

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confidence: 99%

Pyruvate Tolerance Test in Chronic Uremic Patients

Campanacci¹,

Guarnieri²,

Faccini³

et al. 1973

Nephron

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After intravenous pyruvate administration, the rate of decay of the blood pyruvate was significantly lower in the chronic uremic patients than in the healthy subjects. This difference could not be ascribed to a reduced renal excretion of pyruvate. Lower blood 2-oxoglutarate levels were found during the test in chronic uremic patients. The impaired glucose tolerance observed in chronic uremia could in part depend on a reduced pyruvate oxidation in the citric acid cycle.

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“…It is interesting that acetate metabolism is impaired in diabetic sheep [3] and a glucose intolerance is present also in chronic uremia [14]. It is possible that in chronic uremic patients the acetate is not adequately oxidized in the citric acid cycle, owing to a reduced activity of the cycle [7,12,18].…”

Section: Discussionmentioning

confidence: 99%

Acetate Intolerance in Chronic Uremic Patients

Guarnieri

Carretta

Toigo

et al. 1979

Nephron

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The metabolic effects of an acute acetate load have been investigated in chronic uremic patients and in controls. The decay rate of blood acetate levels was significantly lower in patients than in controls. Higher levels of blood acetoacetate and 2-oxoglutarate and plasma triglycerides were observed in the patients after the load. No difference was detectable in plasma levels of unesterified fatty acids and cholesterol between the two groups of subjects. Acetate oxidation in citric acid cycle may be reduced in uremia owing to a lack of coenzyme A. These observations raise the possibility that chronic acetate administration with the dialysate induces hypertriglyceridemia and accelerates the development of atherosclerosis in hemodialysis patients.

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Metabolic studies of acetoacetate, pyruvate, lactate and citrate in uremic acidosis

Cited by 15 publications

References 8 publications

Carbohydrate and Lipid Metabolism during Continuous Ambulatory Peritoneal Dialysis (CAPD): The Effect of a Single Dialysis Cycle

Carbohydrate and Lipid Metabolism during Continuous Ambulatory Peritoneal Dialysis (CAPD): The Effect of a Single Dialysis Cycle

Pyruvate Tolerance Test in Chronic Uremic Patients

Acetate Intolerance in Chronic Uremic Patients

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