Metabolic signatures in pancreatic ductal adenocarcinoma: diagnostic and therapeutic implications
Ruining Gong,
Yonglu Hu,
Qian Yu
et al.
Abstract:Pancreatic ductal adenocarcinoma (PDAC) is the prototypical aggressive cancer that develops in nutrient-deficient and hypoxic microenvironment. PDAC overcomes these restrictions by employing unconventional tactics for the procurement and usage of fuel sources. The substantial reprogramming of PDAC cells metabolism is driven by oncogene-mediated cell-autonomous pathways. PDAC cells use glucose, glutamine, and lipids for energy and depend on autophagy and macropinocytosis for survival and growth. They also inter… Show more
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