Metabolic signature of healthy lifestyle and its relation with risk of hepatocellular carcinoma in a large European cohort

Abstract

This study identified a metabolic signature reflecting a healthy lifestyle pattern which was inversely associated with HCC risk. The metabolic profile displayed a stronger association with HCC than did the modified HLI derived from questionnaire data. Measuring a specific panel of metabolites may identify strata of the population at higher risk for HCC and can add substantial discrimination compared with questionnaire data. This trial was registered at clinicaltrials.gov as NCT03356535.

Diet-Related Metabolomic Signature of Long-Term Breast Cancer Risk Using Penalized Regression: An Exploratory Study in the SU.VI.MAX Cohort

“…They observed associations between metabolites and, on the one hand, nutritional exposures (in particular coffee, alcohol, fibers, vitamin E and fried foods intake, BMI, physical activity), and on the other hand, risk of HCC (27)(28)(29), colorectal cancer (30,31), and only two dealing with breast cancer (10,32). In particular, most of these studies found metabolites related to alcohol intake, in particular, associated with breast cancer (10) or HCC (27)(28)(29) risks. In our study, among the 14 selected ions; 3 were positively associated to alcohol intake (M286T989, M335T864, M413T967), including piperine and pregnene-triol sulfate.…”

Pathways of Prevention: A Scoping Review of Dietary and Exercise Interventions for Neurocognition

“…also potentially consistent with the increased rates of ADRD among individuals with different apolipoprotein (APOE) genotypes, as the APOE gene was originally discovered because of its lipid metabolizing properties. It is therefore possible that blunted peripheral metabolic function may impair the brain's ability to offset normative neurodegeneration, with marked dysregulation of phospholipid metabolism occurring in the years immediately preceding clinical neurocognitive impairment [101][102][103][104][105].…”

When lifestyles sign

“…Then they evaluated separately in conditional regression models the lifestyle and metabolic signatures and the HCC risk, showing that this "healthy lifestyle metabolic signature" is associated with a reduction of 72% (95% CI: 57-82%) in HCC risk. In particular, this metabolic signature maintains its inverse association with HCC risk after excluding the hepatitispositive cases (OR =0.33), so in the setting of alcoholic and non-alcoholic liver diseases (7). In a second study they performed a mediation analysis assessing to investigate whether the metabolic signature mediated the relation between the previous mentioned lifestyle factors and the risk of HCC (8), showing that the association between each lifestyle factors with HCC risk is strongly mediated by the signature, with the exception of physical activity and hepatitis infection [mediator effect: 0.90 (0.60-1.35) and 1.22 (0.88-1.69), respectively] (8).…”

“…In this scenario, the need to identify NAFLD patients at higher risk of developing HCC is a priority. In this direction, Assi et al published recently 2 interesting papers showing a serum metabolic signature reflecting a healthy lifestyle and associated with a reduction in HCC risk (7,8). They identified 147 cases of HCC and 147 matched controls in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, a multinational prospective European cohort in which questionnaire and interview data about diet habits, lifestyle, medical history and anthropometric measures have been collected at baseline and at regular intervals during the enrollment period from apparently healthy participants, who were followed over time for the occurrence of cancer and other diseases (9).…”

“…Using the PLS analysis, they showed an association between the 7 mentioned lifestyle variables and 7 metabolites. alkyl phosphatidylcholine (PC ae) C30:2], and negatively with glutamic acid and hexoses (7). Then they evaluated separately in conditional regression models the lifestyle and metabolic signatures and the HCC risk, showing that this "healthy lifestyle metabolic signature" is associated with a reduction of 72% (95% CI: 57-82%) in HCC risk.…”