Metabolic risk factors associated with erosive esophagitis

Chua, Chian Sem; Lin, Yu‐Min; Yu, Fangzhou; Hsu, Yi-Hsin; Chen, Jui-Hao; Yang, Kuo-Ching; Shih, Chia-Hui

doi:10.1111/j.1440-1746.2009.05858.x

Cited by 23 publications

(30 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the individual components of metabolic syndrome, hypertension suggested by SBP was the most important mediator of both overweight-ERD and obesity-ERD association. Our findings regarding cardiometabolic risk factors are supported by previous studies on metabolic syndrome components and ERD 35–37 . They reported a significant relationship between ERD and metabolic parameters, such as dyslipidemia (especially hypertriglyceridemia), hyperglycemia, and hypertension.…”

Section: Discussionsupporting

confidence: 90%

Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors

Lee

Lim

Chi

et al. 2017

Sci Rep

View full text Add to dashboard Cite

This study aimed to evaluate whether the relationship between obesity and erosive reflux disease (ERD) is mediated by cardiometabolic risk factors. This cohort study included subjects who underwent repeated endoscopy. To assess whether the association between body mass index (BMI) and ERD development was mediated by cardiometabolic parameters, multivariate Cox proportional hazard models were fitted for mediation analysis. Of 15,154 subjects with negative index endoscopy findings during health check-up, 11,686 subjects who underwent repeated endoscopy were included. During follow-up, 1,367 incident ERD events (11.7%) were observed. Without mediation effect, the multivariate adjusted hazard ratio of BMI was 1.21 (95% CI, 1.03–1.42) in overweight and 1.39 (95% CI, 1.19–1.62) in obese individuals compared to normal weight individuals. When the metabolic syndrome was included as a mediator, the hazard ratio became 1.19 (95% CI, 1.00–1.40) in overweight and 1.29 (95% CI, 1.10–1.52) in obese individuals. Both systolic blood pressure and triglyceride level were found to fully mediate the effect of BMI on ERD. Fasting glucose level was a partial mediator. The estimated percentage of total effect mediated by cardiometabolic risk factors was 35.4%. Cardiometabolic parameters partially or fully mediate the association between overweight and obesity and incident ERD.

show abstract

Section: Discussionsupporting

confidence: 90%

Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors

Lee

Lim

Chi

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Of these, 19 studies (18 independent populations) reported the association between central adiposity and EE, 12,14,27–43 17 studies (15 independent populations) reported the association between central adiposity and BE, 9–11,13,16,35,44–54 and 6 studies reported the association between central adiposity and EAC. 13,55–59 Lee et al 33,34 reported the relationship between central adiposity and EE by using both WHR and CT-measured visceral adipose tissue area (in a subset of patients).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 40 studies, 18 were performed in the Asian population (including 17 studies on risk of EE) 12,14,27–34,37–43 and the remainder in the Western population. Eight studies used visceral adipose tissue area as measure of central adiposity (4 each in patients with EE 12,28,29,34 and BE 16,44,46,53 ), 23 studies used WHR (7 studies on EE, 30,34–37,39,40 11 studies on BE, 9–11,13,35,48–52,54 and 5 studies on EAC 13,56–59 ).…”

Section: Resultsmentioning

confidence: 99%

Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis

Singh

Sharma

Murad

et al. 2013

Clinical Gastroenterology and Hepatology

309

232

View full text Add to dashboard Cite

BACKGROUND & AIMS Central adiposity has been implicated as a risk factor for Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), possibly promoting the progression from inflammation to metaplasia and neoplasia. We performed a systematic review and meta-analysis of studies to evaluate the association between central adiposity and erosive esophagitis (EE), BE, and EAC, specifically exploring body mass index (BMI)–independent and gastroesophageal reflux (GERD)–independent effects of central adiposity on the risk of these outcomes. METHODS We performed a systematic search of multiple databases through March 2013. Studies were included if they reported effect of central adiposity (visceral adipose tissue area, waist-hip ratio, and/or waist circumference) on the risk of EE, BE, and EAC. Summary adjusted odds ratio (aOR) estimates with 95% confidence intervals (CIs), comparing highest category of adiposity with the lowest category of adiposity, were calculated by using randomeffects model. RESULTS Forty relevant articles were identified. Compared with patients with normal body habitus, patients with central adiposity had a higher risk of EE (19 studies; aOR, 1.87; 95% CI, 1.51–2.31) and BE (17 studies; aOR, 1.98; 95% CI, 1.52–2.57). The association between central adiposity and BE persisted after adjusting for BMI (5 studies; aOR, 1.88; 95% CI, 1.20–2.95). Refluxindependent association of central adiposity and BE was observed in studies that used GERD patients as controls or adjusted for GERD symptoms (11 studies; aOR, 2.04; 95% CI, 1.44–2.90). In 6 studies, central adiposity was associated with higher risk of EAC (aOR, 2.51; 95% CI, 1.54–4.06), compared with normal body habitus. CONCLUSIONS On the basis of a meta-analysis, central adiposity, independent of BMI, is associated with esophageal inflammation (EE), metaplasia (BE), and neoplasia (EAC). Its effects are mediated by reflux-dependent and reflux-independent mechanisms.

show abstract

“…Male gender, hiatal hernia, Helicobacter pylori infection, smoking, and alcohol consumption can increase the risk of erosive esophagitis (EE) [3, 4]. In addition, common features of metabolic syndrome are risk factors for EE [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Abdominal Visceral to Subcutaneous Adipose Tissue Ratio Is Associated with Increased Risk of Erosive Esophagitis

Kim

Kang

et al. 2017

Dig Dis Sci

View full text Add to dashboard Cite

BackgroundTo investigate the association between abdominal fat distribution represented by the visceral fat area (VFA) to subcutaneous fat area (SFA) ratio, and erosive esophagitis (EE). MethodsSeven hundred and twenty-eight participants aged >40 years underwent physical examination, blood tests, esophagogastroduodenoscopy, and abdominal computer tomography at Chung-Ang University Hospital from 2007 to 2012.ResultsOf 728 subjects, 65 (8.9%) had EE. The EE patients had higher body mass index, metabolic syndrome prevalence, triglyceride levels, and blood pressure (P < 0.05). The mean VFA/SFA ratio was higher in the EE group than in the non-EE group (1.30 vs. 0.92, P < 0.001). The predominance of EE in the group with higher VFA/SFA ratio was higher than in the group with lower VFA/SFA ratio (P < 0.001). A VFA/SFA ratio ≥1.165 had good accuracy to predict EE (area under the receiver-operating characteristic curve, 0.643). The VFA/SFA ratio and visceral fat volume were positively correlated with the severity of EE (P = 0.002), and a VFA/SFA ratio ≥1.165 was strongly correlated with the severity of EE (P < 0.001).ConclusionThe high VFA/SFA ratio can be a useful clinical predictor of EE.

show abstract

Metabolic risk factors associated with erosive esophagitis

Abstract: Obesity and hypertriglyceridemia, which are key components of metabolic syndrome, are moderate independent risk factors for erosive esophagitis.

Cited by 23 publications

References 23 publications

Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors

Relationship between obesity and development of erosive reflux disease: A mediation analysis of the role of cardiometabolic risk factors

Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis

Abdominal Visceral to Subcutaneous Adipose Tissue Ratio Is Associated with Increased Risk of Erosive Esophagitis

Contact Info

Product

Resources

About