Metabolic response to injury and sepsis: changes in protein metabolism

Evaluation of prognostic value of selected biochemical markers in surgically treated patients with acute mediastinitis

“…It is thought to be a consequence of malnutrition, liver dysfunction, disturbed protein and albumin synthesis by inflammatory mediators that can directly inhibit transcription of genes responsible for albumin synthesis [34,35]. Trauma and sepsis initiate a cascade of events that lead to accelerated protein degradation, decreased rate of synthesis of selected proteins, and increased amino acid catabolism and nitrogen loss [36]. The results of our studies are similar to the observations of other authors.…”

High mean fasting glucose levels independently predict poor outcome and delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage

“…Another possibility is that high levels of mean fasting glucose during the first weeks after SAH reflect an acute metabolic response, including insulin resistance persisting during the acute ilness. Such a state has been described in other groups of critically ill patients19 – 21 and has been associated with cardiovascular complications and poor clinical outcome previously, but mostly in the long term and in patients who already had abnormalities of glucose metabolism 22 – 24. Although previous studies did not report a relation between DM and SAH occurrence,25 – 27 it is possible that high fasting glucose levels after aneurysmal SAH represent pre-existent, but previously unrecognised, abnormalities in glucose metabolism.…”

Higher dimensional (Hi-D) separation strategies dramatically improve the potential for cancer biomarker detection in serum and plasma

“…Of the 22 highest abundance plasma proteins, at least 10 proteins vary by at least 25% in the acute phase response, including: albumin, transferrin, fibrinogen, alpha-1-antitrypsin, C3, haptoglobin, ceruloplasmin, C4, factor B, and C9 [19,3]. At least 7 of the remaining 12 high abundance proteins have also been reported to change concentrations in the acute phase response, including: prealbumin [20], alpha-1-acid glycoprotein, alpha-2-macroglobulin [21], apolipoprotein A-1 [22], apolipoprotein B [23], lipoprotein (a) [24], and C8 [25,3].…”