Metabolic response to exercise in childhood brain tumor survivors: A pilot controlled study

Papalia, Honoré; Rochette, Emmanuelle; Pereira, Bruno; Merlin, Étienne; Kanold, Justyna; Duché, Pascale

doi:10.1002/pbc.28053

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…57 Metabolic symptoms caused by HFD can be improved by exercise, partially as a result of protected HFD neurons that are POMC-expressing and increased leptin signalling in the hypothalamus which controls energy homeostasis in the whole body. 41 As brain tumour survivors who are children with reduced fitness compared to healthy children, and differences are not present in substrate utilization throughout sub maximal exercise, child brain tumour survivors should be encouraged to do PA. 43 Evidence of lower bilateral posterior parietal cortex activities caused by exercise and larger bilateral prefrontal cortex activity was observed. 71 These results provide standardized and reliable measures of behaviour, achievement and cognitive processes related with detailed measures of obesity and fitness.…”

Section: Discussionmentioning

confidence: 95%

“…Higher risks of insulin resistance, central obesity and dyslipidaemia have been found among children. 43 Type 2 diabetes (T2D) risks become increased due to obesity in youth and they are both considered as neurocognitive deficit risk factors. Risks of T2D and obesity could be reduced with exercise along with cognitive function improvements.…”

Section: Exercise Type 2 Diabetes and Obesitymentioning

confidence: 99%

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Exercise and brain function in obese & overweight people - a review

Ghosal¹,

Ghosal²

2021

JDMDC

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Obesity has become a global epidemic and has almost tripled since 1975. Obesity results from an excessive accumulation of fat in the adipose tissues and has correlations with cardiovascular comorbidities. Cognition is affected by obesity mainly due to structural and functional brain changes. Exercise and physical activity for general populations have shown to have advantages at all levels in the management of obesity. This review aims to examine if exercise can improve brain function in obese and overweight people. Studies have looked at the obesity effects on factors associated with deteriorating cognitive and motor functions. Obesity has been found to have an association with a reduction in cognition and brain plasticity. There are important functions of exercise for aiding the overall health of the brain however the ways in which brain health is supported by exercise are not well understood. Therefore, it is important to explore if exercise can improve brain function and cognition along with reducing a decline in motor functions. This review also discusses how brain function can be improved with aerobic exercise. Exercise interventions that start early in life seems to have huge benefits for brain function. For long enough periods of time, moderately intense exercise has been found to be especially advantageous for young people.

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Section: Discussionmentioning

confidence: 95%

Section: Exercise Type 2 Diabetes and Obesitymentioning

confidence: 99%

Exercise and brain function in obese & overweight people - a review

Ghosal¹,

Ghosal²

2021

JDMDC

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“…It has been estimated that children diagnosed with malignant brain tumors have a survival rate of approximately 70%. These children have an increased risk of dyslipidemia, obesity, and insulin resistance [ 128 ]. Howell et al used Mendelian randomization (MR) and genetic variants to uncover evidence of a link between risk factors and the development of glioma.…”

Section: Assessing the Risks Of Gbm With Childhood Obesitymentioning

confidence: 99%

Childhood Obesity: A Potential Key Factor in the Development of Glioblastoma Multiforme

Sachdeva¹,

Ghosh

Ghosh³

et al. 2022

Life

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Glioblastoma multiforme (GBM) is a malignant primary tumor type of the central nervous system (CNS). This type of brain tumor is rare and is responsible for 12–15% of all brain tumors. The typical survival rate of GBM is only 12 to 14 months. GBM has a poor and unsatisfactory prognosis despite advances in research and therapeutic interventions via neurosurgery, radiation, and chemotherapy. The molecular heterogeneity, aggressive nature, and occurrence of drug-resistant cancer stem cells in GB restricts the therapeutic efficacy. Interestingly, the CNS tumors in children are the second most usual and persistent type of solid tumor. Since numerous research studies has shown the association between obesity and cancer, childhood obesity is one of the potential reasons behind the development of CNS tumors, including GBM. Obesity in children has almost reached epidemic rates in both developed and developing countries, harming children’s physical and mental health. Obese children are more likely to face obesity as adults and develop non-communicable diseases such as diabetes and cardiovascular disease as compared to adults with normal weight. However, the actual origin and cause of obesity are difficult to be pointed out, as it is assumed to be a disorder with numerous causes such as environmental factors, lifestyle, and cultural background. In this narrative review article, we discuss the various molecular and genetic drivers of obesity that can be targeted as potential contributing factors to fight the development of GBM in children.

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Physical and functional performance assessment in pediatric oncology: a systematic review

et al. 2021

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Background Research indicates reduced physical performance from diagnosis into survivorship of pediatric cancer patients. However, there is no systematic information or guideline available on the methods to assess physical performance and function in this population. The purpose was to systematically compile and describe assessments of physical performance and function in patients and survivors of pediatric cancer, including cardiorespiratory fitness, muscle strength, speed, balance, flexibility, functional mobility, gait and motor performance test batteries. Methods We searched the databases PubMed, SPORTDiscus, and Cochrane Database and performed abstract and full-text selection of 2619 articles according to the Cochrane Handbook of Systematic Reviews. Information on patients characteristics, assessments, information on validity and reliability, and relevant references was extracted. Results In summary, 63 different assessments were found in 149 studies including 11639 participants. Most studies evaluated cardiorespiratory fitness and muscle strength with the majority conducted off treatment. Some outcomes (e.g. speed) and diagnoses (e.g. neuroblastoma) were severely underrepresented. With the exception of gait, leukemia patients represented the largest group of individuals tested. Conclusions Insufficient data and patient heterogeneity complicate uniform recommendations for assessments. Our results support researchers and practitioners in selecting appropriate assessment to meet their specific research questions or individual daily practice needs. Impact This systematic review includes 149 studies and provides a comprehensive summary of 63 assessments to evaluate cardiorespiratory fitness, muscle strength, speed, balance, flexibility, functional mobility, gait or motor performance test batteries in patients and survivors of pediatric cancer. We present the most studied fields within the pediatric cancer population, which are cardiorespiratory fitness and muscle strength, off treatment phase, and leukemia patients. We propose research priorities by identification of subgroups in terms of cancer type, phase of treatment, and outcome of interest that are underrepresented in studies currently available.

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Metabolic response to exercise in childhood brain tumor survivors: A pilot controlled study

Cited by 4 publications

References 39 publications

Exercise and brain function in obese & overweight people - a review

Exercise and brain function in obese & overweight people - a review

Childhood Obesity: A Potential Key Factor in the Development of Glioblastoma Multiforme

Physical and functional performance assessment in pediatric oncology: a systematic review

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