Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular Permeability

Lomana, Adrián López García de; Vilhjalmsson, Arnar Ingi; McGarrity, Sarah; Sigurðardóttir, Rósa Sólveig; Anuforo, Ósk; Viktorsdóttir, Alexía Rós; Kotronoulas, Aris; Bergmann, Andreas; Franzson, Leifur; Halldórsson, Haraldur; Henriksen, H; Wade, Charles E.; Johansson, Pär I.; Rolfsson, Óttar

doi:10.3390/ijms23063162

Cited by 8 publications

(4 citation statements)

References 75 publications

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“…In healthy vessels, mental stress causes the release of norepinephrine which binds to ⍺1 receptors, stimulates smooth muscles, and results in vasoconstriction (Froese et al., 2020; Harris et al., 2000). On the other hand, mental stress also causes a rise in circulating epinephrine, leading to β2‐mediated vasodilation by increasing nitric oxide bioavailability, which is responsible for endothelium‐dependent vasodilation (Carter et al., 2005; Conti et al., 2013; García De Lomana et al., 2022; Joyner & Casey, 2009). The vascular endothelium has an important role in the control of vascular tone (Furchgott & Zawadzki, 1980; Sandoo et al., 2010).…”

Section: Discussionmentioning

confidence: 99%

Blunted brachial blood flow velocity response to acute mental stress in PTSD females

Tahmin,

Tahsin,

Wattero

et al. 2024

Physiological Reports

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Post‐traumatic stress disorder (PTSD) is associated with increased cardiovascular disease (CVD) risk. Compared with males, females are twice as likely to develop PTSD after trauma exposure, and cardiovascular reactivity to stress is a known risk factor for CVD. We aimed to examine hemodynamic responses to acute mental stress in trauma‐exposed females with and without a clinical diagnosis of PTSD. We hypothesized that females with PTSD would have higher heart rate (HR), blood pressure (BP), and lower blood flow velocity (BFV) responsiveness compared with controls. We enrolled 21 females with PTSD and 21 trauma‐exposed controls. We continuously measured HR using a three‐lead electrocardiogram, BP using finger plethysmography, and brachial BFV using Doppler ultrasound. All variables were recorded during 10 min of supine rest, 5 min of mental arithmetic, and 5 min of recovery. Females with PTSD were older, and had higher BMI and higher resting diastolic BP. Accordingly, age, BMI, and diastolic BP were covariates for all repeated measures analyses. Females with PTSD had a blunted brachial BFV response to mental stress (time × group, p = 0.005) compared with controls, suggesting greater vasoconstriction. HR and BP responses were comparable. In conclusion, our results suggest early impairment of vascular function in premenopausal females with PTSD.

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Section: Discussionmentioning

confidence: 99%

Blunted brachial blood flow velocity response to acute mental stress in PTSD females

Tahmin,

Tahsin,

Wattero

et al. 2024

Physiological Reports

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show abstract

“…49 Furthermore, in vitro studies showed that high levels of catecholamine neurotransmitters trigger endothelial adrenergic receptors, leading to endothelial permeability and glycocalyx loss in endothelial cells. 177 Combined, these findings suggest also a contribution of increased sympathetic nerve activity to endothelial dysfunction in CKD.…”

Section: Sympathetic Nerve Activitymentioning

confidence: 94%

Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease

Baaten

Vondenhoff

Noels

2023

Circulation Research

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The endothelium is considered to be the gatekeeper of the vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due to the proinflammatory, prothrombotic and uremic environment caused by the decline in kidney function, adding to the increase in cardiovascular complications in this vulnerable patient population. In this review, we discuss endothelial cell functioning in healthy conditions and the contribution of endothelial cell dysfunction to cardiovascular disease. Further, we summarize the phenotypic changes of the endothelium in chronic kidney disease patients and the relation of endothelial cell dysfunction to cardiovascular risk in chronic kidney disease. We also review the mechanisms that underlie endothelial changes in chronic kidney disease and consider potential pharmacological interventions that can ameliorate endothelial health.

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“…Certain metabolites have been found to exhibit a dose-response relationship with the adrenaline-noradrenaline equimolar treatment. 12 These 46 metabolites align with the glutathione-ascorbate cycle and nitric oxide biosynthesis pathway. Upon catecholamine stimulation, an increase in glucose consumption and aerobic respiration was observed in endothelial cells, which supports how catecholamine stimulation of endothelial cells can cause increased oxidative stress and nitric oxide metabolism, and is associated with increased vascular permeability.…”

Section: Letter To the Editor 125mentioning

confidence: 96%

Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

Goh,

Wee,

Chua

et al. 2023

Semin Thromb Hemost

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Hematohidrosis, or hematidrosis, is a rare medical condition characterized by blood oozing from the intact skin in the absence of a bleeding problem. 1 Prior to modern-day medical literature, these phenomena had been captured in Renaissance and also present-day artwork. While the purpose of medical literature is to aid healthcare professionals and patients in the better understanding and treatment of disease, a significant proportion of Renaissance art commissioned by the church depicted scenes from the Bible, for the purposes of a visual depiction of key events to promote teachings of the faith, and to encourage devotion to God.We explored the theme of hematohidrosis in historic art and performed a rapid review of modern medical literature, noting that the earliest works featuring hematohidrosis were depictions in Renaissance art as early as the 15th century. The German painter known as Meister Der Freisinger Passion (Master of the Freising Passion) depicts Jesus Christ in the Garden of Gethsemane at the foot of the Mount of Olives, sweating drops of blood (►Fig. 1). Around him, his disciples sit, fast asleep. Another piece given the same name, the Christus am Ölberg, is featured in one of the frescoes of the Tabernakelbildstock in Welsberg-Taisten (Wayside Shrine of Tesido; ►Fig. 2). Believed to have been painted by Wolfgang Sauber in the 1460s, it depicts Christ with his hands clasped together in prayer as bloody sweat dots his forehead. These two artworks provide visual testimony to Luke's account of the Gospel of Jesus Christ praying in the Garden of Gethsemane before crucifixion. The motif of the cup is featured in the two artworks, echoing Christ's words in Luke 22:42, "Father, if you are willing, remove this cup from me. Nevertheless, not My will, but Yours, be done." The cup is a symbol of the cup of God's wrath that Jesus takes upon Himself, as He takes on the sins of the nations. In the words of preacher Charles Spurgeon, "at one tremendous draught of love, He drank damnaarticle published online

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Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular Permeability

Cited by 8 publications

References 75 publications

Blunted brachial blood flow velocity response to acute mental stress in PTSD females

Blunted brachial blood flow velocity response to acute mental stress in PTSD females

Endothelial Cell Dysfunction and Increased Cardiovascular Risk in Patients With Chronic Kidney Disease

Hematohidrosis in 15th Century Renaissance Art and a Review of Modern Literature

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