Metabolic reprogramming involves in transition of activated/resting CD4+ memory T cells and prognosis of gastric cancer
Yue Sun,
Li Liu,
Yuanyuan Fu
et al.
Abstract:BackgroundLittle is known on how metabolic reprogramming potentially prompts transition of activated and resting CD4+ memory T cells infiltration in tumor microenvironment of gastric cancer (GC). The study aimed to evaluate their interactions and develop a risk model for predicting prognosis in GC.MethodsExpression profiles were obtained from TCGA and GEO databases. An immunotherapeutic IMvigor210 cohort was also enrolled. CIBERSORT algorithm was used to evaluate the infiltration of immune cells. The ssGSEA me… Show more
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