Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect

Bin, Yuling; Hu, Hongsai; Tian, Feng; Wen, Zhenhua; Yang, Meifeng; Wu, Ben-Hua; Wang, Lisheng; Yao, Jun; Li, Defeng

doi:10.3389/fonc.2021.745209

Cited by 11 publications

(5 citation statements)

References 171 publications

(175 reference statements)

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“…In gastric cancer, glucose metabolism and Ca 2+ intracellular concentration alterations were the main metabolism-related changes [ 46 , 47 , 48 ].…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

SP and KLF Transcription Factors in Cancer Metabolism

Orzechowska-Licari

LaComb

Mojumdar

et al. 2022

IJMS

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Tumor development and progression depend on reprogramming of signaling pathways that regulate cell metabolism. Alterations to various metabolic pathways such as glycolysis, oxidative phosphorylation, lipid metabolism, and hexosamine biosynthesis pathway are crucial to sustain increased redox, bioenergetic, and biosynthesis demands of a tumor cell. Transcription factors (oncogenes and tumor suppressors) play crucial roles in modulating these alterations, and their functions are tethered to major metabolic pathways under homeostatic conditions and disease initiation and advancement. Specificity proteins (SPs) and Krüppel-like factors (KLFs) are closely related transcription factors characterized by three highly conserved zinc fingers domains that interact with DNA. Studies have demonstrated that SP and KLF transcription factors are expressed in various tissues and regulate diverse processes such as proliferation, differentiation, apoptosis, inflammation, and tumorigenesis. This review highlights the role of SP and KLF transcription factors in the metabolism of various cancers and their impact on tumorigenesis. A better understanding of the role and underlying mechanisms governing the metabolic changes during tumorigenesis could provide new therapeutic opportunities for cancer treatment.

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“…In gastric cancer, glucose metabolism and Ca 2+ intracellular concentration alterations were the main metabolism-related changes [ 46 , 47 , 48 ].…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

SP and KLF Transcription Factors in Cancer Metabolism

Orzechowska-Licari

LaComb

Mojumdar

et al. 2022

IJMS

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“…In addition to this, there are natural compounds that show promise for the treatment of cancer, such as crocin, one of the bioactive compounds in saffron, which can reduce the expression of HIF-1α in gastric cancer tumor cells, thus reducing the migration, invasion and EMT of gastric cancer cells [125,190]. Another natural compound, ginsenoside 20(S)-Rg3 extracted from Panax ginseng, promotes the degradation of HIF-1α in ovarian cancer by targeting miR-519a-5p resulting in the inhibition of EMT and suppression of HK2 expression, a crucial enzyme in the Warburg effect [126,191].…”

Section: Hif-1 Inhibitormentioning

confidence: 99%

Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches

Navarro

Ortega²,

Santeliz³

et al. 2022

Pharmaceutics

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The constant changes in cancer cell bioenergetics are widely known as metabolic reprogramming. Reprogramming is a process mediated by multiple factors, including oncogenes, growth factors, hypoxia-induced factors, and the loss of suppressor gene function, which support malignant transformation and tumor development in addition to cell heterogeneity. Consequently, this hallmark promotes resistance to conventional anti-tumor therapies by adapting to the drastic changes in the nutrient microenvironment that these therapies entail. Therefore, it represents a revolutionary landscape during cancer progression that could be useful for developing new and improved therapeutic strategies targeting alterations in cancer cell metabolism, such as the deregulated mTOR and PI3K pathways. Understanding the complex interactions of the underlying mechanisms of metabolic reprogramming during cancer initiation and progression is an active study field. Recently, novel approaches are being used to effectively battle and eliminate malignant cells. These include biguanides, mTOR inhibitors, glutaminase inhibition, and ion channels as drug targets. This review aims to provide a general overview of metabolic reprogramming, summarise recent progress in this field, and emphasize its use as an effective therapeutic target against cancer.

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“…Tumor metabolic reprogramming includes upregulated aerobic glycolysis, increased glutamine, and lipid accumulation, which support cancer cell development [ 13 ]. Alterations to metabolic pathways can affect the survival of patients with gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Implication of Plasma Metabolites in Gastric Cancer

Cao

Lyu

Chen

et al. 2023

IJMS

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Gastric cancer (GC) typically carries a poor prognosis as it is often diagnosed at a late stage. Altered metabolism has been found to impact cancer outcomes and affect patients’ quality of life, and the role of metabolites in gastric cancer prognosis has not been sufficiently understood. We aimed to establish a prognostic prediction model for GC patients based on a metabolism-associated signature and identify the unique role of metabolites in the prognosis of GC. Thus, we conducted untargeted metabolomics to detect the plasma metabolites of 218 patients with gastric adenocarcinoma and explored the metabolites related to the survival of patients with gastric cancer. Firstly, we divided patients into two groups based on the cutoff value of the abundance of each of the 60 metabolites and compared the differences using Kaplan–Meier (K-M) survival analysis. As a result, 23 metabolites associated with gastric cancer survival were identified. To establish a risk score model, we performed LASSO regression and Cox regression analysis on the 60 metabolites and identified 8 metabolites as an independent prognostic factor. Furthermore, a nomogram incorporating clinical parameters and the metabolic signature was constructed to help individualize outcome predictions. The results of the ROC curve and nomogram plot showed good predictive performance of metabolic risk features. Finally, we performed pathway analysis on the 24 metabolites identified in the two parts, and the results indicated that purine metabolism and arachidonic acid metabolism play important roles in gastric cancer prognosis. Our study highlights the important role of metabolites in the progression of gastric cancer and newly identified metabolites could be potential biomarkers or therapeutic targets for gastric cancer patients.

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Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect

Cited by 11 publications

References 171 publications

SP and KLF Transcription Factors in Cancer Metabolism

SP and KLF Transcription Factors in Cancer Metabolism

Metabolic Reprogramming in Cancer Cells: Emerging Molecular Mechanisms and Novel Therapeutic Approaches

Prognostic Implication of Plasma Metabolites in Gastric Cancer

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