Metabolic reprogramming and signalling cross-talks in tumour–immune interaction: a system-level exploration
Mudita Shukla,
Rupa Bhowmick,
Piyali Ganguli
et al.
Abstract:Tumour-immune microenvironment (TIME) is pivotal in tumour progression and immunoediting. Within TIME, immune cells undergo metabolic adjustments impacting nutrient supply and the anti-tumour immune response. Metabolic reprogramming emerges as a promising approach to revert the immune response towards a pro-inflammatory state and conquer tumour dominance. This study proposes immunomodulatory mechanisms based on metabolic reprogramming and employs the regulatory flux balance analysis modelling approach, which i… Show more
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