Metabolic Reconstruction Elucidates the Lifestyle of the Last Diplomonadida Common Ancestor

Jiménez-González, Alejandro; Andersson, Jan O.

doi:10.1128/msystems.00774-20

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2022

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“…There are also free-living diplomonads like Trepomonas sp. PC1, and comparative genomics have shown that the free-living life style most likely is a secondary adaptation and evolved from its parasitic ancestor 7 , 8 .…”

Section: Background and Summarymentioning

confidence: 99%

A chromosome-scale reference genome for Spironucleus salmonicida

Jiménez-González

Kurt

et al. 2022

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Spironucleus salmonicida is a diplomonad causing systemic infection in salmon. The first S. salmonicida genome assembly was published 2014 and has been a valuable reference genome in protist research. However, the genome assembly is fragmented without assignment of the sequences to chromosomes. In our previous Giardia genome study, we have shown how a fragmented genome assembly can be improved with long-read sequencing technology complemented with optical maps. Combining Pacbio long-read sequencing technology and optical maps, we are presenting here this new S. salmonicida genome assembly in nine near-complete chromosomes with only three internal gaps at long repeats. This new genome assembly is not only more complete sequence-wise but also more complete at annotation level, providing more details into gene families, gene organizations and chromosomal structure. This near-complete reference genome will aid comparative genomics at chromosomal level, and serve as a valuable resource for the diplomonad community and protist research.

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Section: Background and Summarymentioning

confidence: 99%