Metabolic Rather than Pathological Response to Preoperative Chemoradiotherapy Is a Stronger Predictor of Survival in cStage IIB-IV Esophageal Cancer

Motoyama, Satoru; Sato, Yusuke; Maruyama, Kiyotomi; Usami, Shuetsu; Yoshino, Kei; Nakatsu, Toshinobu; Sasaki, Tomohiko; Wakita, Akiyuki; Kawakita, Yuta; Li, Jiajia; Anbai, Akira; Ishiyama, Koichi; Saito, Hajime; Minamiya, Yoshihiro

doi:10.21873/anticanres.11808

Cited by 1 publication

(1 citation statement)

References 11 publications

(12 reference statements)

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“…Different methods have been proposed to evaluate the FDG PET-CT images in EC, including visual assessment (qualitative) and semiquantitative (SUV) and quantitative analyses ( 81 ). However, the best method for balancing the accuracy, practicality, and clinical applicability in PET has not been established.…”

Section: Discussionmentioning

confidence: 99%

Interim position emission tomography-computed tomography during multimodality treatment of locally advanced esophageal cancer: a scoping review

Zhu,

Hao,

Tseng

et al. 2023

Quant Imaging Med Surg

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Background Among cancers, esophageal cancer (EC) has one of the highest incidences and mortality in Asia. As recognized in many national guidelines, functional imaging performed with position emission tomography is recommended for patients with locally advanced disease. This review evaluated evidence for the use of fluorodeoxyglucose (FDG) interim positron emission tomography (PETint) in bimodality (chemoradiation) and trimodality (chemoradiation followed by surgery) management of locally advanced esophageal cancer (LAEC), with a focus on its prognostic and predictive value. Methods The MEDLINE database was searched from January 1, 2001, to January 1, 2022, as part of a scoping review. References of selected articles were manually checked to identify other articles meeting the inclusion criteria; only original articles were included, and reviews, guidelines, letters, editorials, and case reports were excluded. Results A total of 63 articles were included in this review. PET-computed tomography (PET-CT) is recognized as having a significant role in the assessment of treatment response. Studies on the predictive PETint suggest that it has a certain value, particularly for early response. Identification of poor responders or nonresponders soon after commencement of multimodality treatment allows for treatment modification. Conclusions The scoping review indicated variable utility for the prognostic value of PETint. There is a need to improve its accuracy, which can likely be achieved through greater standardization of measurements and reporting and testing as well as combination with other promising measures of response to residual disease.

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Section: Discussionmentioning

confidence: 99%

Interim position emission tomography-computed tomography during multimodality treatment of locally advanced esophageal cancer: a scoping review

Zhu,

Hao,

Tseng

et al. 2023

Quant Imaging Med Surg

View full text Add to dashboard Cite

show abstract

Metabolic Rather than Pathological Response to Preoperative Chemoradiotherapy Is a Stronger Predictor of Survival in cStage IIB-IV Esophageal Cancer

Abstract: Metabolic response for NACRT was an independent prognostic factor and a more powerful predictor of survival compared to pathological response.

Cited by 1 publication

References 11 publications

Interim position emission tomography-computed tomography during multimodality treatment of locally advanced esophageal cancer: a scoping review

Interim position emission tomography-computed tomography during multimodality treatment of locally advanced esophageal cancer: a scoping review

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