Metabolic rate depression is induced by caloric restriction and correlates with rate of development and lifespan in a parthenogenetic insect

Roark, Alison McCombe; Bjorndal, Karen A.

doi:10.1016/j.exger.2009.03.004

Cited by 24 publications

(25 citation statements)

References 51 publications

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“…These studies also reported no correlation between metabolic rate and lifespan. However, a few studies on mice (Liao et al, 2011), houseflies (Cooper et al, 2004), parthenogenetic insects (Roark and Bjorndal, 2009), and yeasts (Lin et al, 2002) showed that metabolic rate was significantly altered by DR in these cases, and it was positively correlated with lifespan. This paradox can be qualitatively explained by Fig.…”

Section: Explanation Of Controversial Empirical Results With the Concmentioning

confidence: 96%

On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

Hou

Amunugama

2015

Mechanisms of Ageing and Development

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The relationship between energy expenditure and longevity has been a central theme in aging studies. Empirical studies have yielded controversial results, which cannot be reconciled by existing theories. In this paper, we present a simple theoretical model based on first principles of energy conservation and allometric scaling laws. The model takes into considerations the energy tradeoffs between life history traits and the efficiency of the energy utilization, and offers quantitative and qualitative explanations for a set of seemingly contradictory empirical results. We show that oxidative metabolism can affect cellular damage and longevity in different ways in animals with different life histories and under different experimental conditions. Qualitative data and the linearity between energy expenditure, cellular damage, and lifespan assumed in previous studies are not sufficient to understand the complexity of the relationships. Our model provides a theoretical framework for quantitative analyses and predictions. The model is supported by a variety of empirical studies, including studies on the cellular damage profile during ontogeny; the intra- and inter-specific correlations between body mass, metabolic rate, and lifespan; and the effects on lifespan of (1) diet restriction and genetic modification of growth hormone, (2) the cold and exercise stresses, and (3) manipulations of antioxidant.

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Section: Explanation Of Controversial Empirical Results With the Concmentioning

confidence: 96%

On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

Hou

Amunugama

2015

Mechanisms of Ageing and Development

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“…Resting metabolic rate (RMR) in invertebrates and other ectotherms and basal metabolic rate (BMR) in endothermic vertebrates represent the minimum energy consumption rate and therefore the maintenance cost of the metabolic machinery of a resting animal. In insects, starvation reduced RMR in some cases (Harshman et al 1999;Nespolo et al 2005;Roark and Bjorndal 2009), although in some cases reduced CO 2 emission rate reflects changes in energy substrate use rather than reduced oxygen consumption (Sinclair et al 2011). However, artificial selection experiments suggest that reduced energy consumption rate is not necessarily the key to starvation resistance (Pijpe et al 2008).…”

Section: Dietary Restriction In Lepidoptera Introductionmentioning

confidence: 97%

Aging, Life Span, and Energetics under Adult Dietary Restriction in Lepidoptera

Niitepõld

Pérez

Boggs³

2014

Physiological and Biochemical Zoology

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Stressful conditions can affect resource allocation among different life-history traits. The effect of dietary restriction (DR) on longevity and reproduction has been studied in many species, but we know little about its effects on energetics, especially in flying animals that have high energy demand. We assessed the effects of DR on metabolic rate throughout the entire adult life span in two butterfly species, Colias eurytheme and Speyeria mormonia. We cut the food intake of adult females in half and measured resting metabolic rate (RMR) and flight metabolic rate (FMR) together with body mass repeatedly throughout life. In both species, DR reduced body mass, but mass-corrected FMR was not affected, indicating that flight capacity was retained. DR lowered RMR and reduced fecundity but had no effect on life span. FMR declined with age, but the rate of senescence was not affected by DR. In contrast, aging had a strong negative effect on RMR only in control females, whereas food-restricted females had more stable RMR throughout their lives. The results suggest that flight capacity is conserved during nutritional stress but that investment in flight and survival may negatively affect other important physiological processes when resources are limited.

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“…Lifespan extension from dietary restriction has been observed in a variety of organisms (Mair and Dillin, 2008), including insects as diverse as the fruit fly, the house fly, a butterfly, and even a stick insect (Carey et al, 2002, Cooper et al, 2004, Boggs and Ross, 1993, Roark and Bjorndal, 2009). In Drosophila melanogaster , for example, dietary restriction in adults can extend lifespan by over 50% (Grandison et al, 2009, Partridge et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti

Joy

Arik

Corby‐Harris

et al. 2010

Experimental Gerontology

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Dietary restriction extends lifespan in many organisms, but little is known about how it affects hematophagous arthropods. We demonstrated that diet restriction during either larval or adult stages extends Aedes aegypti lifespan. A. aegypti females fed either single or no blood meals survived 30–40% longer than those given weekly blood meals. However, mosquitoes given weekly blood meals produced far more eggs. To minimize reproduction’s impact on lifespan, adult mosquitoes were fed artificial blood meals containing <10% of the protein in normal human blood, minimizing egg production. A. aegypti fed artificial blood meals containing 25 mg/ml of BSA had significantly shorter lifespans than those fed either 10 or 5 mg/ml. To assess the impact of larval dietary restriction on adult lifespan, we maintained larval A. aegypti on 2X, 1X (normal diet), 0.5X or 0.25X diets. Adult mosquitoes fed 0.5X and 0.25X larval diets survived significantly longer than those fed the 2X larval diet regardless of adult diet. In summary, dietary restriction during both larval and adult stages extends lifespan. This diet-mediated lifespan extension has important consequences for understanding how dietary restriction regulates lifespan and disease transmission.

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Metabolic rate depression is induced by caloric restriction and correlates with rate of development and lifespan in a parthenogenetic insect

Cited by 24 publications

References 51 publications

On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

On the complex relationship between energy expenditure and longevity: Reconciling the contradictory empirical results with a simple theoretical model

Aging, Life Span, and Energetics under Adult Dietary Restriction in Lepidoptera

The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti

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