Metabolic profiling studies on the toxicological effects of realgar in rats by 1H NMR spectroscopy

Wei, Lai; Liao, Peiqiu; Wu, Huifeng; Li, Xiaojing; Pei, Fengkui; Li, Weisheng; Wu, Yidi

doi:10.1016/j.taap.2008.11.010

Cited by 132 publications

(79 citation statements)

References 61 publications

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“…The material basis and mechanism of TCM could be studied effectively by using some metabolomics methods such as the application of different techniques (liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, nuclear magnetic resonance, etc.) (Wang et al, 2005d;Kang et al, 2008;Wei et al, 2009). Furthermore, this approach is considered to have the potential to uncover a general mechanism of ADRs induced by TCM and to advance the development of Chinese herbal medicine.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the adverse reactions induced by natural product‐derived drugs

Zeng

Jiang

2010

British J Pharmacology

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Compared with the therapeutic effects of established medicinal drugs, it is often considered that natural product-derived drugs are of a more benign nature in side-effects, which has made natural medicines become a popular form of therapy. Traditional Chinese medicine (TCM) is generally considered as being natural and harmless. TCM has been paid much more attention than before and widely used for the treatment nowadays. However, with the increasing cases of adverse drug reactions (ADRs), the ADRs induced by TCM are becoming more widely recognized. Some ADRs are sometimes even life-threatening. This article reviews literatures on ADRs induced by TCM which was published in the past 10 years. A total of 3122 cases including complete data are selected for the present analysis. From the data of the 3122 cases, statistics is carried out to the distribution of administration routes and time of the occurrence of ADRs, the prognosis of ADRs, sex and age factors, types and clinical symptoms of ADRs, and drugs involved in ADRs. In addition, occurrence and influencing factors of TCM-induced diseases are also analysed, which includes spices confusion, processing drugs improperly, toxic components, long-term medication, improper concerted application, interaction of TCM and Western medicine. It is concluded that the efficacy and toxicity of TCM, often using the compound prescription involving various plants and animals, resulted from a variety of chemical constituents, which lead to a comprehensive response in the human body. The 'toxicity' of TCM should be correctly recognized and reasonably utilized.

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Section: Discussionmentioning

confidence: 99%

Analysis of the adverse reactions induced by natural product‐derived drugs

Zeng

Jiang

2010

British J Pharmacology

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“…In addition, the biological differences can also distort biological interpretation due to the different tolerances and sensitivities of clams to environmental contaminants in marine toxicology studies. As a system biology approach, metabolomics has been widely used in toxicology Wei et al, 2008;Wei et al, 2009;Williams et al, 2009Williams et al, , 2014Zhang et al, 2006;).…”

Section: Biological Differences Between White and Zebra Clamsmentioning

confidence: 99%

Toxicological evaluation of two pedigrees of clam Ruditapes philippinarum as bioindicators of heavy metal contaminants using metabolomics

Cao

2015

Environmental Toxicology and Pharmacology

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EcotoxicologyHeavy metals Metabolomics NMR a b s t r a c t Heavy metal pollution has been of great concern in the Bohai marine environment. Manila clam Ruditapes philippinarum has been used as a bioindicator in marine toxicology. In this study, NMR-based metabolomics was used to ascertain whether there were significant biological differences between two dominant pedigrees (White and Zebra) of clam and evaluate the suitability of two pedigrees for marine environmental toxicology, together with antioxidant enzymatic analysis. Our results indicated that there were significant biological differences between White and Zebra clams based on the metabolic profiles and antioxidant enzyme activities. In details, the metabolic profiles showed higher levels of amino acids and succinate in Zebra clam digestive glands and higher levels of ATP in White clam digestive glands, respectively. The superoxide dismutase activities in control White and Zebra clam samples were significantly different. Additionally, White clam was more sensitive to Cd based on the significant accumulation of Cd, antioxidant enzymatic alterations and sensitive metabolic changes. Overall, we concluded that White clam could be a preferable bioindicator for marine environmental toxicology.

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“…[28][29][30] It was performed in this study to assess the biological impact of SWCNT injection on liver metabolism as a general index of toxicity. HR-MAS 1 H NMR spectroscopy of intact tissue enables the simultaneous measurement of both lipids and low molecular weight metabolites, which is important in a toxicological diagnosis.…”

Section: Hr-masmentioning

confidence: 99%

In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques

Faraj¹,

Fauvelle²,

Luciani³

et al. 2011

IJN

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International audienceSingle-walled carbon nanotubes (SWCNT) hold promise for applications as contrast agents and target delivery carriers in the field of nanomedicine. When administered in vivo, their biodistribution and pharmacological profile needs to be fully characterized. The tissue distribution of carbon nanotubes and their potential impact on metabolism depend on their shape, coating, and metallic impurities. Because standard radiolabeled or fluorescentlylabeled pharmaceuticals are not well suited for long-term in vivo follow-up of carbon nanotubes, alternative methods are required

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Metabolic profiling studies on the toxicological effects of realgar in rats by 1H NMR spectroscopy

Cited by 132 publications

References 61 publications

Analysis of the adverse reactions induced by natural product‐derived drugs

Analysis of the adverse reactions induced by natural product‐derived drugs

Toxicological evaluation of two pedigrees of clam Ruditapes philippinarum as bioindicators of heavy metal contaminants using metabolomics

In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques

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